68 research outputs found
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116311/1/feb2s0014579307012264.pd
Transcription factor ZBP-89 is required for STAT1 constitutive expression
IFNγ is a pro-inflammatory cytokine that potentiates p53-independent apoptosis in a variety of cell types. STAT1 is the primary mediator of IFNγ action. ZBP-89 is a transcription factor that binds to the G/C-rich elements and mediates p53-independent apoptosis. In this study, site-directed mutagenesis revealed that a G-rich element from +171 to +179 within the first intron of the STAT1 gene is critical for optimal STAT1 promoter activity. Electrophoretic mobility shift assays and promoter analysis revealed that ZBP-89 binds directly to this STAT1 G-rich element along with Sp1 and Sp3. Reduction of ZBP-89 with siRNA attenuated both basal and IFNγ-induced STAT1 expression and subsequently diminished the activation of apoptotic markers, e.g. caspase-3 and PARP. Taken together, we conclude that ZBP-89 is required for constitutive STAT1 expression and in this way contributes to the ability of cells to be activated by IFNγ
Transcription factor ZBP-89 regulates p53 transcriptional activity by interacting with DNA binding and C-terminal domains
Transcription factor ZBP-89 inhibits cell growth and promotes apoptosis by stabilizing tumor suppressor protein p53
Adenoviral protein E1A prevents potentiatiation of butyrate-activated p21WAFL by ZBP-89 through direct binding
Spiro compounds as IKZF2 degraders and their preparation, pharmaceutical compositions and use in the treatment of cancer
http://deepblue.lib.umich.edu/bitstream/2027.42/191181/2/WO 2023-183540 Al.pd
Piperidine-2,6-dione derivatives as cereblon-binding agents and their preparation
http://deepblue.lib.umich.edu/bitstream/2027.42/191180/2/WO 2023-183607 Al.pdfDescription of WO 2023-183607 Al.pdf : Published versio
- …