Interatomic coulombic decay rate in endohedral complexes

Interatomic coulombic decay (ICD) in van der Waals endohedral complexes was predicted to be anomalously fast. However, the available theoretical calculations of the ICD rates in endohedral complexes only consider the equilibrium geometry, in which the encapsulated atom is located at the centre of the fullerene cage. Here we show analytically that the dominant contribution of the dipole plasmon resonance to ICD does not deviate from its equilibrium geometry value, while contributions of higher multipole plasmons to the ICD can be neglected for most atomic displacements possible for an endohedral complex at room temperature. This is in contrast to the behaviour predicted for ionic endohedral compounds. Our results show that the conclusion of the earlier works on the ultrafast character of the ICD in endohedral complexes holds generally for a wide range of geometries possible under a thermal distribution, rather than only for the equilibrium geometry

Non-coding RNAs underlying chemoresistance in gastric cancer.

BackgroundGastric cancer (GC) is a major health issue in the Western world. Current clinical imperatives for this disease include the identification of more effective biomarkers to detect GC at early stages and enhance the prevention and treatment of metastatic and chemoresistant GC. The advent of non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long-non coding RNAs (lncRNAs), has led to a better understanding of the mechanisms by which GC cells acquire features of therapy resistance. ncRNAs play critical roles in normal physiology, but their dysregulation has been detected in a variety of cancers, including GC. A subset of ncRNAs is GC-specific, implying their potential application as biomarkers and/or therapeutic targets. Hence, evaluating the specific functions of ncRNAs will help to expand novel treatment options for GC.ConclusionsIn this review, we summarize some of the well-known ncRNAs that play a role in the development and progression of GC. We also review the application of such ncRNAs in clinical diagnostics and trials as potential biomarkers. Obviously, a deeper understanding of the biology and function of ncRNAs underlying chemoresistance can broaden horizons toward the development of personalized therapy against GC