108 research outputs found
Shared Autonomy via Hindsight Optimization
In shared autonomy, user input and robot autonomy are combined to control a
robot to achieve a goal. Often, the robot does not know a priori which goal the
user wants to achieve, and must both predict the user's intended goal, and
assist in achieving that goal. We formulate the problem of shared autonomy as a
Partially Observable Markov Decision Process with uncertainty over the user's
goal. We utilize maximum entropy inverse optimal control to estimate a
distribution over the user's goal based on the history of inputs. Ideally, the
robot assists the user by solving for an action which minimizes the expected
cost-to-go for the (unknown) goal. As solving the POMDP to select the optimal
action is intractable, we use hindsight optimization to approximate the
solution. In a user study, we compare our method to a standard
predict-then-blend approach. We find that our method enables users to
accomplish tasks more quickly while utilizing less input. However, when asked
to rate each system, users were mixed in their assessment, citing a tradeoff
between maintaining control authority and accomplishing tasks quickly
Cellular Procoagulant Activity Dictates Clot Structure and Stability as a Function of Distance From the Cell Surface
Thrombin concentration modulates fibrin structure and fibrin structure modulates clot stability; however, the impact of localized, cell surface-driven in situ thrombin generation on fibrin structure and stability has not previously been evaluated
High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy
About one-third of patients with type 1 diabetes mellitus develop nephropathy, which often progresses to end-stage renal diseases. The present study demonstrates that below-normal Elmo1 expression in mice ameliorates the albuminuria and glomerular histological changes resulting from long-standing type 1 diabetes, whereas above-normal Elmo1 expression makes both worse. Increasing Elmo1 expression leads to aggravation of oxidative stress markers and enhances the expression of fibrogenic genes. Suppressing Elmo1 action in human patients could be a promising option for treating/preventing the progressive deterioration of renal function in diabetes
Dental therapists in general dental practice. A literature review and case study analysis to determine what works, why, how and in what circumstances
Introduction
In the United Kingdom, policy and guidance changes regarding the role of Dental Therapists (DTs) were implemented in recent years with a view to changing dental care to a more preventive‐focussed, teamwork approach. However, success in the adoption of this model of working has been varied.
Aims
Adopting a realist approach, our aim was, to examine the use of DTs in general dental practices in Wales, exploring what works, why, how and in what circumstances.
Materials and Methods
The research comprised two stages. (i) A structured literature search, dual‐coding papers for high‐level factors describing the conditions or context(s) under which the mechanisms operated to produce outcomes. From this, we derived theories about how skill‐mix operates in the general dental service. (ii) Six case studies of general dental practices (three with a Dental Therapist/three without a Dental Therapist) employing a range of skill‐mix models incorporating semi‐structured interviews with all team members. We used the case studies/interviews to explore and refine the theories derived from the literature.
Results
Eighty‐four papers were coded. From this coding, we identified seven theories which reflected factors influencing general dental practices within three broad contexts: the dental practice as a business, as a healthcare provider, and as a workplace. We tested these theories in interviews with 38 dental team members across the six care studies. As a result, we amended five of the theories.
Conclusion
Our analysis provides theory about outcomes that DTs may facilitate and the mechanisms that may assist the work of DTs within different contexts of general dental practice
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice
About one third of patients with type 1 diabetes mellitus develop nephropathy, which often progresses to end-stage renal diseases. The present study demonstrates that below normal transforming growth factor (TGF) β1 expression ameliorates the nephropathy and decreased glomerular filtration rate resulting from long-standing type 1 diabetes, while above normal TGFβ1 expression makes both worse. Reducing TGFβ1 expression in the glomerulus is more important in avoiding the decrease in glomerular filtration rate than altering expression in the tubule, while expression in the tubule is more important in controlling interstitial fibrosis and albuminuria. Suppressing TGFβ1 action in the kidney as a whole, or specifically in podocytes, could be a promising option for treating/preventing the progressive deterioration of renal function in diabetes
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