The effect of gold, silver and zinc oxide nanoparticles on oxidative stress parameters level in the liver, heart and lung of male mice

Background & Objective: Nowadays, the beneficial effects of nanomaterials are accepted in medicine and industry. Considering the increasing use of nanoparticles and their possible toxicity, the effect of nanoparticles on oxidative stress markers was investigated in this study. Material & Methods: In this experimental- interventional study, 32 Balb mice were divided into 4 groups of 8. The control group received saline, and other three groups received gold, silver, and zinc oxide nanoparticles at a concentration of 100 PPM with IP injection during 28 days. After anesthesia, the tissues of liver, heart and lung were removed, and the activity level of oxidative stress markers was evaluated. Results: MDA level was significantly increased in zinc oxide treatment group in all three tissues and in gold treatment group in liver tissue. This factor showed a significant decrease in silver nanoparticle treatment in these tissues. The activity of catalase and glutathione peroxidase enzymes in the treatment of silver nanoparticle showed a significant increase. While in the treatment group with zinc oxide and gold nanoparticles, the activity of these enzymes decreased, this decrease was significant only in zinc oxide nanoparticle. Conclusion: It is concluded that the silver nanoparticle acts as a useful nanoparticle by decreasing MDA and oxidative stress and inducing antioxidant enzymes, while the effect of zinc oxide nanoparticle shows its toxicity