Discovery of strong CIV absorption in the highest redshift quasar

We report the near-IR detection of a prominent CIV absorption in the rest-frame UV spectrum of the most distant known QSO, SDSS J104433.04-012502.2, at z=5.80. This QSO was recently observed with XMM-Newton and it was found to be notably X-ray weak. The equivalent width of the CIV absorption feature (~10 A) strongly supports the idea that the X-ray faintness of this QSO is due to heavy absorption by gas with a column density N_H > 10^{24} cm^-2. The shape of the CIV feature suggests that this is a Broad Absorption Line QSO. Although absorbed by a huge column of gas, the observed continuum in the 0.9-2.4um range (~1300-3500 A rest frame) exactly matches the template of unabsorbed QSOs without invoking any reddening (E(B-V)<0.08 mag), indicating that dust in the absorbing gas is either absent or composed of large grains.Comment: 4 pages, 2 figures, accepted for publication in A&A Letter

Duodenal Leiomyosarcoma Mimicking a Pancreatic Pseudocyst

A case of duodenal leiomyosarcoma presenting as a cystic mass is reported. Amylase, tumour markers levels in the cyst fluid and radiological findings suggested an inflammatory pancreatic pseudocyst. Exploratory laparotomy and frozen section examination showed a smooth muscle tumour of the duodenum. Pancreatoduodenectomy with pylorus-preser vation was performed and the patient remained symptom-free at 8 months follow-up

Emergency contraception: unresolved clinical, ethical and legal quandaries still linger

Emergency contraception (EC) has been prescribed for decades, in order to lessen the risk of unplanned and unwanted pregnancy following unprotected intercourse, ordinary contraceptive failure, or rape. EC and the linked aspect of unintended pregnancy undoubtedly constitute highly relevant public health issues, in that they involve women's self-determination, reproductive freedom and family planning. Most European countries regulate EC access quite effectively, with solid information campaigns and supply mechanisms, based on various recommendations from international institutions herein examined. However, there is still disagreement on whether EC drugs should be available without a physician's prescription and on the reimbursement policies that should be implemented. In addition, the rights of health care professionals who object to EC on conscience grounds have been subject to considerable legal and ethical scrutiny, in light of their potential to damage patients who need EC drugs in a timely fashion. Ultimately, reproductive health, freedom and conscience-based refusal on the part of operators are elements that have proven extremely hard to reconcile; hence, it is essential to strike a reasonable balance for the sake of everyone's rights and well-being

Dynamical Mass Estimates of Large-Scale Filaments in Redshift Surveys

We propose a new method to measure the mass of large-scale filaments in galaxy redshift surveys. The method is based on the fact that the mass per unit length of isothermal filaments depends only on their transverse velocity dispersion. Filaments that lie perpendicular to the line of sight may therefore have their mass per unit length measured from their thickness in redshift space. We present preliminary tests of the method and find that it predicts the mass per unit length of filaments in an N-body simulation to an accuracy of ~35%. Applying the method to a select region of the Perseus-Pisces supercluster yields a mass-to-light ratio M/L_B around 460h in solar units to within a factor of two. The method measures the mass-to-light ratio on length scales of up to 50h^(-1) Mpc and could thereby yield new information on the behavior of the dark matter on mass scales well beyond that of clusters of galaxies.Comment: 21 pages, LaTeX with 6 figures included. Submitted to Ap

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis.

Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc). Ultra-conserved regions (UCRs) are a class non-coding sequences that are conserved in humans, mice and rats. More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, and are altered at transcriptional level in tumorigenesis. To identify the T-UCR profiles that are dysregulated in Barretts mucosa transformation, microarray analysis was performed on a discovery set of 51 macro-dissected samples obtained from 14 long-segment BE patients. Results were validated in an independent series of esophageal biopsy/surgery specimens and in two murine models of Barretts esophagus (i.e. esophagogastric-duodenal anastomosis). Progression from normal to BE to adenocarcinoma was each associated with specific and mutually exclusive T-UCR signatures that included up-regulation of uc.58-, uc.202-, uc.207-, and uc.223- and down-regulation of uc.214+. A 9 T-UCR signature characterized BE versus Sq (with the down-regulation of uc.161-, uc.165-, and uc.327-, and the up-regulation of uc.153-, uc.158-, uc.206-, uc.274-, uc.472-, and uc.473-). Analogous BE-specific T-UCR profiles were shared by human and murine lesions. This study is the first demonstration of a role for T-UCRs in the transformation of Barretts mucosa

Y RNA: an overview of their role as potential biomarkers and molecular targets in human cancers

Y RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were published, mostly scattered across different tumor types and, in some cases, also suffering from methodological limitations. Nonetheless, these sparse data may be used to make some estimations and suggest routes to better understand the role of Y RNA in cancer formation and characterization. Here we summarize the current knowledge about Y RNA in multiple types of cancer, also including a paragraph about tumors that might be included in this list in the future, if more evidence becomes available. The picture arising indicates that Y RNA might be useful in tumor characterization, also relying on non-invasive methods, such as the analysis of the content of extracellular vesicles (EV) that are retrieved from blood plasma and other bodily fluids. Due to the established role of Y RNA in DNA replication, it is possible to hypothesize their therapeutic targeting to inhibit cell proliferation in oncological patients

Pulsar Searches with the SKA

The Square Kilometre Array will be an amazing instrument for pulsar astronomy. While the full SKA will be sensitive enough to detect all pulsars in the Galaxy visible from Earth, already with SKA1, pulsar searches will discover enough pulsars to increase the currently known population by a factor of four, no doubt including a range of amazing unknown sources. Real time processing is needed to deal with the 60 PB of pulsar search data collected per day, using a signal processing pipeline required to perform more than 10 POps. Here we present the suggested design of the pulsar search engine for the SKA and discuss challenges and solutions to the pulsar search venture.Comment: 4 pages, 1 figure. To be published in Proceedings of IAU Symposium 337: Pulsar Astrophysics - The Next 50 Year

The TNG Near Infrared Camera Spectrometer

NICS (acronym for Near Infrared Camera Spectrometer) is the near-infrared cooled camera-spectrometer that has been developed by the Arcetri Infrared Group at the Arcetri Astrophysical Observatory, in collaboration with the CAISMI-CNR for the TNG (the Italian National Telescope Galileo at La Palma, Canary Islands, Spain). As NICS is in its scientific commissioning phase, we report its observing capabilities in the near-infrared bands at the TNG, along with the measured performance and the limiting magnitudes. We also describe some technical details of the project, such as cryogenics, mechanics, and the system which executes data acquisition and control, along with the related software.Comment: 7 pages, 5 figures, compiled with A&A macros. A&A in pres

Discovery of two infrared supernovae: a new window on the SN search

We report the discovery of two supernovae (SN 1999gw and SN 2001db) obtained within the framework of an infrared monitoring campaign of Luminous Infrared Galaxies, aimed at detecting obscured supernovae. SN 2001db, extinguished by Av~5.5 mag, is the first supernova discovered in the infrared which has received the spectroscopic confirmation. This result highlights the power of infrared monitoring in detecting obscured SNe and indicates that optical surveys are probably missing a significant fraction of SNe, especially in obscured systems such as starburst galaxies. The preliminary estimate of SN rate in LIRG galaxies is about an order of magnitude higher than that expected from optical surveys.Comment: 9 pages, 7 figures, accepted for publication in A&

The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors

Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors