Mating system and population genetic structure of the bulldog ant Myrmecia pavida

Understanding the evolution of the alternative mating strategies of monandry and polyandry is a fundamental problem in evolutionary biology because of the cost-benefit trade-offs associated with mating for females. The problem is particularly intriguing in the social insects because queens in most species appear to be obligately monandrous (i.e., only a single male fathers their offspring), while those in a minority of species have evolved high, and sometimes extreme, polyandry. One group which may shed particular insight is the ant subfamily Myrmeciinae (Myrmecia and Nothomyrmecia). Here we examine the population and colony genetic structure of the bulldog ant Myrmecia pavida CLARK, 1951 by genotyping offspring workers from 45 colonies. We find little evidence of geographic structuring or inbreeding in the population, indicating that the species outbreeds, most probably in mating swarms. We also find that queens of M pavida show moderately high polyandry, with 84% having mated with between two and seven males, and an overall mean observed mating frequency of 3.8. This is significantly higher than previously reported for queens of Nothomyrmecia macrops, in which most females mate singly. This was similar to that of M pyriformis, M brevinoda, and M pilosula, the three congenerics for which mating frequencies have recently been reported. The two genera in the Myrmeciinae therefore appear to show multiple transitions in mating frequency and further investigation of the subfamily may be highly informative for disentangling the forces driving the evolution of alternative mating strategies

Numerical analysis of TIROS radiation observations

June 1965.Includes bibliographical references.Sponsored by the CSU project on the Meterology of the Southeast Asia Summer Monsoon DA 28-043-AMC-01303 (E)

Closing Fireside Chat with the Assistant Attorney General for the U.S. Department of Justice Antitrust Division

This Closing Fireside Chat was the final session of the 16th annual Silicon Flatirons Center conference, The Digital Broadband Migration: The Evolving Industry Structure of the Digital Broadband Landscape, held on Feb. 1, 2016 in the Wittemyer Courtroom of the University of Colorado Law School. At the time this conference was held, William J. Baer was Assistant Attorney General for Antitrust in the United States Department of Justice. On April 17, 2016, President Obama asked Mr. Baer to become Acting Associate Attorney General of the United States. Video of this interview with Assistant Attorney General Baer is available at https://www.youtube.com/watch?v=C351xEX0h4g [https://perma.cc/3HH7-3DP4]

Closing Fireside Chat with the Assistant Attorney General for the U.S. Department of Justice Antitrust Division

This Closing Fireside Chat was the final session of the 16th annual Silicon Flatirons Center conference, The Digital Broadband Migration: The Evolving Industry Structure of the Digital Broadband Landscape, held on Feb. 1, 2016 in the Wittemyer Courtroom of the University of Colorado Law School. At the time this conference was held, William J. Baer was Assistant Attorney General for Antitrust in the United States Department of Justice. On April 17, 2016, President Obama asked Mr. Baer to become Acting Associate Attorney General of the United States. Video of this interview with Assistant Attorney General Baer is available at https://www.youtube.com/watch?v=C351xEX0h4g [https://perma.cc/3HH7-3DP4]

Antitrust Enfocement and High-Technology Markets

Although the antitrust laws apply to all industries, the application must be tempered in each case by the myriad ways in which competition can be modified by structural, behavioral, technological, regulatory, and other characteristics. The Commission applies the antitrust laws with sensitivity to the special characteristics of high-tech industries and of intellectual property, but also with the recognition that--as in other industries--competition plays an important role in spurring innovation and in spreading the benefits of that innovation to consumers. This focus is not new. This balanced approach has roots that go back at least to the 1977 Antitrust Guide to International Operations in the Ford Administration and the 1988 Antitrust Guidelines for International Operations in the last year of the Reagan Administration, and is set forth in the 1995 Antitrust Guidelines for the Licensing of Intellectual Property four years ago. It is also informed by the extensive hearings and detailed reporting by the Commission three years ago on antitrust in the 21st century. Of course, enforcement in this area is not entirely free from controversy. A few critics question whether the antitrust laws that were originally designed to apply to traditional manufacturing and distribution industries should be applied at all to competition in fast-moving industries where products often are quickly outmoded and market share may be ephemeral. Others express concern about the potential conflict between the antitrust laws and the laws that protect intellectual property. Are monopolies granted under U. S. patent laws fundamentally in conflict with the antimonopoly focus of the Sherman Act and later antitrust statutes? Can intellectual property rights coexist with effective antitrust enforcement

Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production

<p>Abstract</p> <p>Background</p> <p>Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects.</p> <p>Objective</p> <p>A study was conducted to establish the effects of controlled diets with different meal frequencies, but similar daily energy intakes, on cytokine production in healthy male and female subjects.</p> <p>Design</p> <p>In a crossover study design with an intervening washout period, healthy normal weight middle-age male and female subjects (n = 15) were maintained for 2 months on controlled on-site one meal per day (OMD) or three meals per day (TMD) isocaloric diets. Serum samples and peripheral blood mononuclear cells (PBMCs) culture supernatants from subjects were analyzed for the presence of inflammatory markers using a multiplex assay.</p> <p>Results</p> <p>There were no significant differences in the inflammatory markers in the serum of subjects on the OMD or TMD diets. There was an increase in the capacity of PBMCs to produce cytokines in subjects during the first month on the OMD or TMD diets.</p> <p>Lower levels of TNF-α, IL-17, MCP-1 and MIP-1β were produced by PBMCs from subjects on the OMD versus TMD diet.</p> <p>Conclusions</p> <p>PBMCs of subjects on controlled diets exhibit hypersensitivities to cellular stimulation suggesting that stress associated with altered eating behavior might affect cytokine production by immune cells upon stimulation. Moreover, stimulated PBMCs derived from healthy individuals on a reduced meal frequency diet respond with a reduced capability to produce cytokines.</p

The developmental origin of adolescent alcohol use: Findings from the Mater University Study of Pregnancy and its outcomes

Background It is unclear whether fetal alcohol exposure contributes to alcohol use in adolescence. In this study, we examine the association between maternal alcohol use in pregnancy and adolescents’ drinking patterns at age 14. Methods The association of maternal alcohol exposure with early drinking was examined in 4363 adolescents taking part to the Mater University Study of Pregnancy (MUSP) and its outcomes, a population based birth cohort study commenced in Brisbane (Australia) in 1981. Mothers and children were followed up at birth, 5 and 14 years after the initial interview. Maternal alcohol use was assessed before and during pregnancy and at the 5 years follow-up. Adolescents’ alcohol use was assessed at child age 14. Results In multivariable analysis those born of mothers who consumed 3+ glasses during pregnancy were at increased risk to report drinking 3+ glasses compared with those whose mothers reported no drinking or drinking up to 2 glasses. Comparisons controlling for drinking before pregnancy and at age 5 found the averaged odds ratio of maternal drinking in pregnancy on risk of reporting alcohol consumption of 3 and more glasses at age 14 was 2.74 (CI 1.70, 4.22). Conclusion Our study suggests that they maybe a biological origin of early drinking. Further studies are needed to better disentangle the nature of the association and the role of other possible confounding factors