58 research outputs found
La espeleología en el centro escolar, una propuesta en el área de la Educación Física
Focused on the area of Physical Education, this article discusses a Teaching Unit proposal about caving to be carried out in the school; different examples of activities are commented and adapted from the natural environment to the educational context. With this proposal, students will have the opportunity to practice this sport in their own centre. Promotion of their personal development, involving physical, cognitive, behavioural aspects and awareness of environment’ respect and care values are also in mind. In this sense, the main purpose of this paper is to offer teachers a resource for doing caving within the different PE contents blocks, both for primary and secondary education.Enfocado al área de la Educación Física, este artículo muestra una propuesta de Unidad Didáctica centrada en el deporte de espeleología para llevarse a cabo en el propio centro escolar; en ella se exponen diferentes ejemplos de actividades, adaptadas del entorno natural al contexto educativo. Con esta propuesta, los alumnos tendrán la oportunidad de experimentar este deporte en su propio centro; se busca, además, fomentar su desarrollo personal en aspectos físicos, cognitivos y conductuales, lo que incluye el desarrollo de la toma de conciencia en torno a los valores de respeto y cuidado del medio ambiente. En este sentido, el objetivo de este trabajo es ofrecer a los docentes un recurso más para trabajar el deporte de la espeleología dentro de los diferentes bloques de contenido, tanto en la educación primaria como en la secundaria
Bases de poder del supervisor, conducta cooperadora y compromiso con la organización
Este trabajo analiza, en el contexto español, las bases de poder de los supervisores y la incidencia que las mismas tienen sobre la conducta cooperadora y el compromiso con la organización de sus subordinados. Los datos analizados pertenecen a 335 sujetos con la menos un año de experiencia laboal a tiempo completo. Mediante la contrastación de un modelo estructural, que relaciona las diversas bases de poder del jefe entre sí y con la conducta cooperadora y el grado de compromiso de los subordinados, se tratan de comprobar las relaciones existentes entre las variables mencionadas. Asimismo, se indican los principales resultados alcanzados y las implicaciones más relevantes que se pueden deducir a partir de los mismos de cara a las prácticas de los directivos
GPPP y SDR como una potente herramienta científica
One of the greatest problems in mobile networks that researchers have always faced on, is the difficulty of obtaining data from a real network. The limited access to commercial networks or the high prices which presents the equipment encourages the use of simulators in order to get data or test some algorithms. However, these problems can be solved with the emerging of the concept of SDR and GPPP. Hence, in this work it is presented a framework which enables their use in a scientific field. Moreover, a set of video experiment has been made, whose analysis shows the flexibility that these platforms offer as well as its potential as a wide source of real network data, introducing itself in this way, as a powerful tool for researching
Influence of SWEP (Study Pregnant Water Exercise) program in perinatal outcomes: Study protocol
Introducción: el entrenamiento mediante ejercicio físico moderado durante el periodo de gestación aporta beneficios tanto a la mujer embarazada como
al feto. Los trabajos de investigación consultados vinculan la actividad física con una reducción del número de cesáreas, de partos instrumentados y con un
parto más fisiológico. Previene igualmente la ganancia excesiva de peso de la mujer, disminuye el riesgo de diabetes gestacional y de hipertensión arterial.
Objetivo: el objetivo de esta investigación es conocer si un programa de ejercicio físico de carácter moderado con el método Study Water
Exercise Pregnant (SWEP), realizado en un medio acuático, contribuye a obtener unos resultados más favorables en la etapa perinatal, tanto
para la mujer como para el bebé.
Material y métodos: el diseño que se llevará a cabo es un ensayo clínico aleatorizado. La muestra estará constituida por 364 gestantes, obtenida
de un universo total de 6.579 partos acontecidos en Granada (España) durante el año 2014. Dicha muestra se ha dividido en dos grupos, uno de
intervención y otro de control. La actividad se realizará en las instalaciones deportivas acuáticas de la Facultad de Ciencias del Deporte de la Universidad
de Granada, que cuentan con dos vasos adecuados a nuestros objetivos, uno polivalente de 25 metros y otro de enseñanza de 12,5 metros.
Resultados: el programa de ejercicios diseñado específicamente para el proyecto denominado SWEP, abarca desde la 20 hasta la 37 semana
de gestación (SG) y consta de tres sesiones semanales, con una duración de 60 minutos cada una. Las sesiones incluirán tres fases: fase de
calentamiento, fase principal en la que el ejercicio se divide en una parte aeróbica y otra de ejercicios de fuerza y resistencia y una final con
estiramientos y relajación. Las variables que se van a estudiar son las siguientes: a) maternas: peso, IMC, tensión arterial, test de O´Sullivan,
aparición de depresión postparto, nivel de autopercepción de salud, calidad del sueño y esfuerzo percibido durante la actividad física; b) fetales:
peso, test de Apgar, perímetro cefálico y SG (semana de gestación al nacimiento); c) periparto: tiempos de dilatación, expulsivo y alumbramiento,
tipo de parto, presencia de episiotomía, tipo de alimentación que recibe el RN y tiempo de lactancia materna exclusiva; y d) descriptivas: edad,
profesión, nivel de estudios, tipo de ejercicio físico realizado previamente y FO (fórmula obstétrica).
Conclusión: con la actividad física acuática moderada, por parte de la embarazada (método SWEP), se pretenden mejorar las variables arriba indicadas.Introduction: Moderate exercise training during the pregnancy benefits both the pregnant woman and the fetus. The research papers consulted
have linked physical activity with the reduction of the number of cesareans, instrumental delivery and with a more physiological delivery. It also
prevents excessive weight gain in women and decreases the risk of gestational diabetes and high blood pressure.
Aims: The aim of this research is to know if an exercise program of moderate character with Water Study Exercise Pregnant (SWEP) method,
performed in an aquatic environment, contributes to have more favorable results in the perinatal period, both for women and baby.
Material and methods: The design is a randomized clinical trial. The sample will consist of 364 pregnant women, with a total universe of 6,579
births occurred in Granada (Spain) during 2014. The sample was divided into two groups, intervention group and control group. The activity will
be carried out in the water sporting facilities of the Faculty of Sports Science of the University of Granada, which have two pools suitable for our
purposes: a 25-meter polyvalent pool and a 12.5-meter pool for training.
Results: The exercise program designed specifically for the project called SWEP is performed from 20 to 37 weeks of gestation (SG), and it
consists of three weekly sessions, with duration of 60 minutes each. Sessions will include three phases: warm-up phase, the main phase in which
the exercise is divided into an aerobic phase and strength training and endurance training phase and a final phase of stretching and relaxation.
The variables that will be studied are: a) Maternal: weight, BMI, blood pressure, O’Sullivan test, postpartum depression, level of self-rated health,
sleep quality and perceived exertion during physical activity; b) fetal: weight, Apgar scores, head circumference and GA (Gestational age); c)
peripartum: time dilation, expulsion and delivery, type of delivery, episiotomy, type of feed received by the RN and time of exclusive breastfeeding;
and d) descriptive: age, occupation, education level, type of exercise done before and OF (obstetric formula).
Conclusion: With aquatic moderate physical activity during pregnancy (method SWEP), we intended to improve the variables above
Clinical and ultrasound thyroid nodule characteristics and their association with cytological and histopathological outcomes: A retrospective multicenter study in high-resolution thyroid nodule clinics
Introduction: Thyroid nodules are a common finding. A high-resolution thyroid nodule
clinic (HR-TNC) condenses all tests required for the evaluation of thyroid nodules into a single
appointment. We aimed to evaluate the clinical outcomes at HR-TNCs. Design and Methods:
A retrospective cross-sectional multicenter study including data from four HR-TNCs in Spain.
We evaluated fine-needle aspiration (FNA) indications and the association between clinical and
ultrasound characteristics with cytological and histopathological outcomes. Results: A total of 2809
thyroid nodules were included; FNA was performed in 82.1%. Thyroid nodules that underwent
FNA were more likely larger, isoechoic, with microcalcifications, and in younger subjects. The rate
of nondiagnostic FNA was 4.3%. A solid component, irregular margins or microcalcifications,
significantly increased the odds of Bethesda IV-V-VI (vs. Bethesda II). Irregular margins and a solid
component were independently associated with increased odds of malignancy. Thyroid nodules
<20 mm and ≥20–<40 mm had a 6.5-fold and 3.3-fold increased risk for malignancy respectively
in comparison with those ≥40 mm. Conclusion: In this large multicenter study, we found that the
presence of a solid component and irregular margins are factors independently related to malignancy
in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy,
this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with
a low rate of nondiagnostic FNA
Impacto de la COVID-19 en los servicios de cirugía cardiovascular en España: Análisis de los grupos relacionados con el diagnóstico (Estudio SECCE-COVID-19 fase 2)
Introducción y objetivos La pandemia por COVID-19 causada por infección del virus SARS-CoV-2 ha saturado al sistema sanitario español, afectándose la atención de las enfermedades cardiovasculares. Queremos cuantificar el impacto de la pandemia en el número de las intervenciones quirúrgicas cardíacas analizando los grupos relacionados con el diagnóstico (GRD) más prevalentes de nuestra especialidad. Métodos A instancias de la Sociedad Española de Cirugía Cardiovascular y Endovascular, se solicitó a todos los centros nacionales que quisieron participar, los datos de los códigos de GRD números 162 (cirugía sobre válvulas cardíacas con infarto o diagnóstico complejo), 163 (cirugía sobre válvulas cardíacas sin infarto o diagnóstico complejo), 165 (bypass coronario con infarto o diagnóstico complejo), 166 (bypass coronario sin infarto o diagnóstico complejo) y 167 (otros procedimientos cardiotorácicos o vasculares torácicos) entre el 1 de marzo de 2020 y el 30 de septiembre de 2020 (siete meses), y como período control las mismas fechas de 2019. Resultados Se recibieron los datos de 24 hospitales, 22 públicos y dos privados. Existió un descenso global en el número de intervenciones del 30% (rango -19 a -42%, p < 0,001) de 4.648 en 2019 a 3.262 en 2020 (-1.386 de diferencia), siendo +7% para el GRD 162 (p = 0,500), -37% para el 163 (p = 0,001), -9% para el 165 (p = 0,304), -32% para el 166 (p = 0,001), y -16% para el 167 (p = 0,062). Conclusiones Existió un descenso global de cirugías estadísticamente significativo en 2020 del 30% respecto del 2019 entre el 1 de marzo y el 30 de septiembre
Safety and effectiveness of isavuconazole in real-life non-neutropenic patients
Objectives: Information is scarce on clinical experiences with non-neutropenic patients with invasive fungal infection (IFI) receiving isavuconazole. We aimed to report the safety and effectiveness of this drug as a first-line treatment or rescue in real life. Methods: A retrospective, observational multicentric study of non-neutropenic patients who received isavuconazole as an IFI treatment at 12 different university hospitals (January 2018-2022). All patients met criteria for proven, probable or possible IFI according to EORTC-MSG. Results: A total of 238 IFIs were treated with isavuconazole during the study period. Combination therapy was administered in 27.7% of cases. The primary IFI was aspergillosis (217, 91.2%). Other IFIs treated with isavuconazole were candidemia (n = 10), mucormycosis (n = 8), histoplasmosis (n = 2), cryptococcosis (n = 2), and others (n = 4). Median time of isavuconazole treatment was 29 days. Only 5.9% (n = 14) of cases developed toxicity, mainly hepatic-related (10 patients, 4.2%). Nine patients (3.8%) had treatment withdrawn. Successful clinical response at 12 weeks was documented in 50.5% of patients. Conclusion: Isavuconazole is an adequate treatment for non-neutropenic patients with IFIs. Toxicity rates were low and its effectiveness was comparable to other antifungal therapies previously reported. (c) 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/
Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation
[Background & Aims] Although there is increasing interest in its use, definitive evidence demonstrating a benefit for postmortem normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) liver transplantation is lacking. The aim of this study was to compare results of cDCD liver transplants performed with postmortem NRP vs. super-rapid recovery (SRR), the current standard for cDCD.[Methods] This was an observational cohort study including all cDCD liver transplants performed in Spain between June 2012 and December 2016, with follow-up ending in December 2017. Each donor hospital determined whether organ recovery was performed using NRP or SRR. The propensity scores technique based on the inverse probability of treatment weighting (IPTW) was used to balance covariates across study groups; logistic and Cox regression models were used for binary and time-to-event outcomes.[Results] During the study period, there were 95 cDCD liver transplants performed with postmortem NRP and 117 with SRR. The median donor age was 56 years (interquartile range 45–65 years). After IPTW analysis, baseline covariates were balanced, with all absolute standardised differences <0.15. IPTW-adjusted risks were significantly improved among NRP livers for overall biliary complications (odds ratio 0.14; 95% CI 0.06–0.35, p <0.001), ischaemic type biliary lesions (odds ratio 0.11; 95% CI 0.02–0.57; p = 0.008), and graft loss (hazard ratio 0.39; 95% CI 0.20–0.78; p = 0.008).[Conclusions] The use of postmortem NRP in cDCD liver transplantation appears to reduce postoperative biliary complications, ischaemic type biliary lesions and graft loss, and allows for the transplantation of livers even from cDCD donors of advanced age.[Lay summary] This is a propensity-matched nationwide observational cohort study performed using livers recovered from donors undergoing cardiac arrest provoked by the intentional withdrawal of life support (controlled donation after circulatory death, cDCD). Approximately half of the livers were recovered after a period of postmortem in situ normothermic regional perfusion, which restored warm oxygenated blood to the abdominal organs, whereas the remainder were recovered after rapid preservation with a cold solution. The study results suggest that the use of postmortem normothermic regional perfusion helps reduce rates of post-transplant biliary complications and graft loss and allows for the successful transplantation of livers from older cDCD donors.Peer reviewe
Multicentric study of cervical cancer screening with human papillomavirus testing and assessment of triage methods in Latin America : the ESTAMPA screening study protocol
Q1Q1Introduction Human papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC.
Methods and analysis Women aged 30–64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months later for another HPV test; those HPV-positive undergo colposcopy with biopsy and treatment as needed. Biological specimens are collected in different visits for triage testing, which is not used for clinical management. The study outcome is histological high-grade squamous intraepithelial or worse lesions (HSIL+) under the lower anogenital squamous terminology. About 50 000 women will be screened and 500 HSIL+ cases detected (at initial and 18 months screening). Performance measures (sensitivity, specificity and predictive values) of triage techniques to detect HSIL+ will be estimated and compared with adjustment by age and study centre.
Ethics and dissemination The study protocol has been approved by the Ethics Committee of the International Agency for Research on Cancer (IARC), of the Pan American Health Organisation (PAHO) and by those in each participating centre. A Data and Safety Monitoring Board (DSMB) has been established to monitor progress of the study, assure participant safety, advice on scientific conduct and analysis and suggest protocol improvements. Study findings will be published in peer-reviewed journals and presented at scientific meetings.
Trial registration number NCT01881659Revista Internacional - Indexad
Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01)
Altres ajuts: Agustí Barnadas: Honoraria: Pfizer. Consulting or Advisory Role: Pfizer, Novartis, Eli Lilly. Speakers'Bureau: Roche, Pfizer, Novartis, Genomic Health International. Travel, Accommodations, Expenses: Roche, Pfizer; Miguel A. Seguí: Consulting or Advisory Role: Roche, Pfizer, Novartis, Amgen, Eisai, Eli Lilly. Speakers' Bureau: Roche, Pfizer, Amgen. Research Funding: Roche (Inst), Novartis (Inst). Travel, Accommodations, Expenses: Roche, Pfizer, Novartis, Amgen.Operable triple-negative breast cancers (TNBCs) have a higher risk of relapse than non-TNBCs with standard therapy. The GEICAM/2003-11_CIBOMA/2004-01 trial explored extended adjuvant capecitabine after completion of standard chemotherapy in patients with early TNBC. Eligible patients were those with operable, node-positive-or node negative with tumor 1 cm or greater-TNBC, with prior anthracycline- and/or taxane-containing chemotherapy. After central confirmation of TNBC status by immunohistochemistry, patients were randomly assigned to either capecitabine or observation. Stratification factors included institution, prior taxane-based therapy, involved axillary lymph nodes, and centrally determined phenotype (basal v nonbasal, according to cytokeratins 5/6 and/or epidermal growth factor receptor positivity by immunohistochemistry). The primary objective was to compare disease-free survival (DFS) between both arms. Eight hundred seventy-six patients were randomly assigned to capecitabine (n = 448) or observation (n = 428). Median age was 49 years, 55.9% were lymph node negative, 73.9% had a basal phenotype, and 67.5% received previous anthracyclines plus taxanes. Median length of follow-up was 7.3 years. DFS was not significantly prolonged with capecitabine versus observation [hazard ratio (HR), 0.82; 95% CI, 0.63 to 1.06; P =.136]. In a preplanned subgroup analysis, nonbasal patients seemed to derive benefit from the addition of capecitabine with a DFS HR of 0.53 versus 0.94 in those with basal phenotype (interaction test P =.0694) and an HR for overall survival of 0.42 versus 1.23 in basal phenotype (interaction test P =.0052). Tolerance of capecitabine was as expected, with 75.2% of patients completing the planned 8 cycles. This study failed to show a statistically significant increase in DFS by adding extended capecitabine to standard chemotherapy in patients with early TNBC. In a preplanned subset analysis, patients with nonbasal phenotype seemed to obtain benefit with capecitabine, although this will require additional validation
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