Current Studies of Acupuncture in Cancer-Induced Bone Pain Animal Models

Acupuncture is generally accepted as a safe and harmless treatment option for alleviating pain. To explore the pain mechanism, numerous animal models have been developed to simulate specific human pain conditions, including cancer-induced bone pain (CIBP). In this study, we analyzed the current research methodology of acupuncture for the treatment of CIBP. We electronically searched the PubMed database for animal studies published from 2000 onward using these search terms: (bone cancer OR cancer) AND (pain OR analgesia) AND (acupuncture OR pharmacopuncture OR bee venom). We selected articles that described cancer pain in animal models. We analyzed the methods used to induce cancer pain and the outcome measures used to assess the effects of acupuncture on CIBP in animal models. We reviewed articles that met our inclusion criteria. Injection of mammary cancer cells into the cavity of the tibia was the most frequently used method for inducing CIBP in the animal models. Among the eight selected studies, five studies demonstrated the effects of electroacupuncture on CIBP. The effects of acupuncture were assessed by measuring pain-related behavior. Future researches will be needed to ascertain the effectiveness of acupuncture for treating CIBP and to explore the specific mechanism of CIBP in animal models

Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients

Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children. Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease status at the time of transplant, conditioning regimen, engraftment kinetics, development of graft-versus-host disease (GVHD), complications, cause of deaths, overall survival (OS), and event-free survival (EFS) were compared between the 2 groups. Results : Among 34 patients with acute lymphoblastic leukemia (ALL), 28 (82.4%) were in the TBI group, while 72.7% (24/33) of patients with myeloid leukemia were in the non-TBI group. Although the 5-year EFS of the 2 groups was similar for all patients (62% vs 63%), the TBI group showed a better 5-year EFS than the non-TBI group when only ALL patients were analyzed (65% vs 17%&#59; P =0.005). In acute myelogenous leukemia patients, the non-TBI group had better survival tendency (73% vs 38%&#59; P=0.089). The incidence of GVHD, engraftment, survival, cause of death, and late complications was not different between the 2 groups. Conclusion : The TBI and non-TBI groups showed comparable results, but the TBI group showed a significantly higher 5-year EFS than the non-TBI group in ALL patients. Further prospective, randomized controlled studies involving larger number of patients are needed to assess the late-onset complications and to compare the socioeconomic quality of life

Geriatric Medicine in South Korea: A Stagnant Reality amidst an Aging Population

In the face of an ever-increasing wave of an aging population, this paper provides an update on the current status of geriatric medicine in Korea, comparing it with global initiatives and suggesting future directions. Older adults require a multifaceted approach, addressing not only comorbidity management but also unmet complex medical needs, nutrition, and exercise to prevent functional decline. In this regard, the World Health Organization's Integrated Care for Older People guidelines underscore the importance of patient-centered primary care in preventing a decline in intrinsic capacity. Despite these societal needs and the ongoing aging process, the healthcare system in Korea has yet to show significant movement or a shift toward geriatric medicine, further complicated by the absence of a primary care system. We further explore global efforts in establishing age-integrative patient-centered medical systems in Singapore, Australia, Canada, the United Kingdom, and Japan. Additionally, we review the unmet needs and social issues that Korean society is currently facing, and local efforts by both government and a private tertiary hospital in Korea. In conclusion, considering the current situation, we propose that the framework of geriatric medicine should form the foundation of the future healthcare system

Soft tissue thickness for placement of an orthodontic miniscrew using an ultrasonic device.

Objectives: To evaluate area- and gender-related differences in the soft tissue thickness of potential areas for installing miniscrews in the buccal-attached gingiva and the palatal masticatory mucosa. Materials and Methods: The sample consisted of 61 Korean young adults. An ultrasonic gingival-thickness meter was used to measure the soft-tissue thickness in the buccal-attached gingiva just adjacent to the mucogingival junction of the upper and lower arches and 4 mm and 8 mm below the gingival crest in the palatal masticatory mucosa. Independent t-test, paired t-test, and one-way analysis of variance were used for statistical analysis. Results: Buccal-attached gingiva thickness in the upper arch was significantly greater in men than in women, but buccal-attached gingiva thickness in the lower arch and palatal masticatory mucosa thickness 4 and 8 mm below the gingival crest did not show gender differences. Significantly thicker soft tissue occurred in the anterior areas in the upper arch and in the posterior areas in the lower arch. In the palatal masticatory mucosa, significantly thicker soft tissue was found 4 mm below the gingival crest in the anterior areas and 8 mm below the gingival crest in the posterior areas. The areas between the canines and the premolars showed higher values than other areas 4 mm below the gingival crest. However, the soft-tissue thickness 8 mm below the gingival crest showed a progressive increase from the anterior to the posterior areas. Conclusion: Measurements of the soft-tissue thickness using an ultrasonic device could help practitioners select the proper orthodontic miniscrew in daily clinical practice

Soft tissue thickness for placement of an orthodontic miniscrew using an ultrasonic device

Objectives: To evaluate area- and gender-related differences in the soft tissue thickness of potential areas for installing miniscrews in the buccal-attached gingiva and the palatal masticatory mucosa. Materials and Methods: The sample consisted of 61 Korean young adults. An ultrasonic gingival-thickness meter was used to measure the soft-tissue thickness in the buccal-attached gingiva just adjacent to the mucogingival junction of the upper and lower arches and 4 mm and 8 mm below the gingival crest in the palatal masticatory mucosa. Independent t-test, paired t-test, and one-way analysis of variance were used for statistical analysis. Results: Buccal-attached gingiva thickness in the upper arch was significantly greater in men than in women, but buccal-attached gingiva thickness in the lower arch and palatal masticatory mucosa thickness 4 and 8 mm below the gingival crest did not show gender differences. Significantly thicker soft tissue occurred in the anterior areas in the upper arch and in the posterior areas in the lower arch. In the palatal masticatory mucosa, significantly thicker soft tissue was found 4 mm below the gingival crest in the anterior areas and 8 mm below the gingival crest in the posterior areas. The areas between the canines and the premolars showed higher values than other areas 4 mm below the gingival crest. However, the soft-tissue thickness 8 mm below the gingival crest showed a progressive increase from the anterior to the posterior areas. Conclusion: Measurements of the soft-tissue thickness using an ultrasonic device could help practitioners select the proper orthodontic miniscrew in daily clinical practice.

Effect of donor–recipient size mismatch on long-term graft survival in pediatric kidney transplantation: a multicenter cohort study

Background Donor–recipient size mismatching is commonly occurs in pediatric kidney transplantation (KT). However, its effect on graft survival remains unknown. This study aimed to determine the effect of donor–recipient size mismatch on the long-term survival rate of transplant kidneys in pediatric KT. Methods A total of 241 pediatric patients who received KT were enrolled. The medical records of all patients were retrospectively reviewed, and the correlation between donor–recipient size mismatch and graft function and long-term graft outcome was analyzed according to donor–recipient size mismatch. Results Recipients and donors’ mean body weight at the time of KT were 34.31 ± 16.85 and 56.53 ± 16.73 kg, respectively. The mean follow-up duration was 96.49 ± 52.98 months. A significant positive correlation was observed between donor–recipient body weight ratio (DRBWR) or donor–recipient body surface area ratio (DRBSR) and graft function until 1 year after KT. However, this correlation could not be confirmed at the last follow-up. The results of long-term survival analysis using Fine and Gray’s subdistribution hazard model showed no significant difference of the survival rate of the transplant kidney according to DRBWR or DRBSR. Conclusion Donor–recipient size mismatch in pediatric KT is not an important factor in determining the long-term prognosis of transplant kidneys

Clinical Characteristics and Long-Term Prognosis of Alport Syndrome: A Retrospective Single-Center Study

Purpose Alport syndrome (AS) is one of the most common inherited renal diseases caused due to mutations of genes encoding specific proteins of the type IV collagen family, and its major clinical manifestations include progressive renal failure, sensorineural deafness, and ocular abnormalities. We investigated the clinical characteristics and long-term prognosis of AS in Korean pediatric and adult populations. Methods We conducted a retrospective review of medical records of 33 children and adults who had been diagnosed or treated with AS from 1985 to 2019. Results The mean age of the 33 patients diagnosed with AS was 16.2±13.6 years, and the male-to-female ratio was 2:1. At the first visit, recurrent gross hematuria was the most common initial symptom. In 10 of 33 patients (30.3%), sensorineural hearing loss (SNHL) was diagnosed, but none had ophthalmic problems. Moreover, 11 of 33 patients (33.3%) had advanced to end-stage renal disease (ESRD), and a significant difference was observed in the age of the patients who progressed to ESRD based on the presence or absence of SNHL (P=0.035). Conclusion SNHL in AS can be an important prognostic factor for long-term deterioration of renal function. Further investigation is required to confirm the clinical course and the genetic characteristics of AS in Korea through prospective national cohort studies

Imaging Findings of Localized Lymphoid Hyperplasia of the Pancreas: a Case Report

We report here on a case of localized lymphoid hyperplasia of the pancreas in a 70-year-old man which manifested as double lesions (uncinate process and tail) in the organ. The lesions were incidentally detected as hypoechoic lesions on ultrasonography and they appeared as delayed enhancing lesions on the contrast-enhanced dynamic CT and MRI. Total pancreatectomy was performed, because malignant tumor could not be excluded according to the preoperative imaging studies and the endoscopic ultrasound-guided biopsy failed. Pathology revealed localized lymphoid hyperplasia. The patient had an uneventful postoperative course. He has been alive for 18 months after surgery