IN SILICO INVESTIGATION OF PHYTOCONSTITUENTS FROM VARIOUS PLANTS AGAINST NEUROINFLAMMATORY MARKERS AS POTENT THERAPEUTIC TARGETS

Abstract Objective: Neuroinflammation is inflammation of the brain and brain tissue. Activation of glial cells (Microgila and astrocytes) takes place during neuroinflammation, due to which a number of inflammatory mediator release in the brain. The objective of the current study is to investigate the anti-neuroinflammatory activity of the phytoconstituents against various inflammatory mediators.Methods: The preliminary screening of plants was done by Lipinski's rule of five. Inflammatory mediators (COX-1, COX-2, TNF-a, IL-1b, iNOS and   nNOS) protein sequence was retrieved from STRING database and modeling of it through SWISS MODEL. And ligands ID was retrieved from ZINC database and its MOL2 format was downloaded for further processing. Docking study of phytoconstituents with ligands were performed by iGEMDOCK. By using ADMET, Absorption, distribution, metabolism, excretion and toxicity properties were predicted.Results: Sissotrin out of the various phytocomponents is the most active component having high binding affinity with all the genes.Conclusion: Sissotrin may be a good inhibitor for neuroinflammatory disorders

Acidity & Catalytic Activity of Modified Zeolite-X

554-55

SiPM: Characterizations, modelling and VLSI front-end dedicated development

In this work we describe the results of performance tests and measures of SiPM of several sizes (1×1, 3×3, 5×5) delivered from MEPHI. The SiPMs have been studied both in steady and pulsed stimuli. Aging and temperature behavior are also discussed. Another test has been performed in order to obtain an electrical model of the SiPM to be used in analog simulations. Finally, a design of a pilot chip with 0.35 μm technology implementing a front-end for SiPM aimed to TOF applications with adjustable thresholds and very high dynamical range is described

Beyond the Mean Field Approximation for Spin Glasses

We study the d-dimensional random Ising model using a Bethe-Peierls approximation in the framework of the replica method. We take into account the correct interaction only inside replicated clusters of spins. Our ansatz is that the interaction of the borders of the clusters with the external world can be described via an effective interaction among replicas. The Bethe-Peierls model is mapped into a single Ising model with a random gaussian field, whose strength (related to the effective coupling between two replicas) is determined via a self-consistency equation. This allows us to obtain analytic estimates of the internal energy and of the critical temperature in d dimensions.Comment: plane TeX file,19 pages. 3 figures may be requested to Paladin at axscaq.aquila.infn.i

Static Chaos in Spin Glasses against quenched disorder perturbations

We study the chaotic nature of spin glasses against perturbations of the realization of the quenched disorder. This type of perturbation modifies the energy landscape of the system without adding extensive energy. We exactly solve the mean-field case, which displays a very similar chaos to that observed under magnetic field perturbations, and discuss the possible extension of these results to the case of short-ranged models. It appears that dimension four plays the role of a specific critical dimension where mean-field theory is valid. We present numerical simulation results which support our main conclusions.Comment: 13 Pages + 7 Figures, Latex File, figures uuencoded at end of fil

A general method to determine replica symmetry breaking transitions

We introduce a new parameter to investigate replica symmetry breaking transitions using finite-size scaling methods. Based on exact equalities initially derived by F. Guerra this parameter is a direct check of the self-averaging character of the spin-glass order parameter. This new parameter can be used to study models with time reversal symmetry but its greatest interest concerns models where this symmetry is absent. We apply the method to long-range and short-range Ising spin glasses with and without magnetic field as well as short-range multispin interaction spin glasses.Comment: 5 pages, 4 figures, Revtex fil

Numerical Simulations of the 4D Edwards-Anderson Spin Glass with Binary Couplings

We present numerical results that allow a precise determination of the transition point and of the critical exponents of the 4D Edwards-Anderson Spin Glass with binary quenched random couplings. We show that the low T phase undergoes Replica Symmetry Breaking. We obtain results on large lattices, up to a volume $V=10^4$: we use finite size scaling to show the relevance of our results in the infinite volume limit.Comment: 18 pages + 17 figures, revised bibliography and minor typos. Added Journal Re

Equilibrium and off-equilibrium simulations of the 4d Gaussian spin glass

In this paper we study the on and off-equilibrium properties of the four dimensional Gaussian spin glass. In the static case we determine with more precision that in previous simulations both the critical temperature as well as the critical exponents. In the off-equilibrium case we settle the general form of the autocorrelation function, and show that is possible to obtain dynamically, for the first time, a value for the order parameter.Comment: 16 pages and 13 figures, uses epsfig.sty and rotate.sty. Some minor grammatical changes. Also available at http://chimera.roma1.infn.it/index_papers_complex.htm

Simplicity of State and Overlap Structure in Finite-Volume Realistic Spin Glasses

We present a combination of heuristic and rigorous arguments indicating that both the pure state structure and the overlap structure of realistic spin glasses should be relatively simple: in a large finite volume with coupling-independent boundary conditions, such as periodic, at most a pair of flip-related (or the appropriate number of symmetry-related in the non-Ising case) states appear, and the Parisi overlap distribution correspondingly exhibits at most a pair of delta-functions at plus/minus the self-overlap. This rules out the nonstandard SK picture introduced by us earlier, and when combined with our previous elimination of more standard versions of the mean field picture, argues against the possibility of even limited versions of mean field ordering in realistic spin glasses. If broken spin flip symmetry should occur, this leaves open two main possibilities for ordering in the spin glass phase: the droplet/scaling two-state picture, and the chaotic pairs many-state picture introduced by us earlier. We present scaling arguments which provide a possible physical basis for the latter picture, and discuss possible reasons behind numerical observations of more complicated overlap structures in finite volumes.Comment: 22 pages (LaTeX; needs revtex), 1 figure (PostScript); to appear in Physical Review

Silicon photomultipliers: On ground characterizations and modelling for use in front-end electronics aimed to space-borne experiments

Abstract Silicon Photomultipliers (Si-PM) consist of an array of semiconductor photodiodes joint on the common substrate and operating in limited geiger mode. A new generation of Si-PM is currently under test in INFN Rome Tor Vergata facilities: they consist of a 5625 element, 3 * 3 mm 2 array with an improved light response. These elements have been characterized. Furthermore, a functional model of the Si-PM has been developed to be used in a VLSI development of front-end electronics