WeNMR: Structural Biology on the Grid

International audienceThe WeNMR (http://www.wenmr.eu) project is a European Union funded international effort to streamline and automate analysis of Nuclear Magnetic Resonance (NMR) and Small Angle X-Ray scattering (SAXS) imaging data for atomic and near-atomic resolution molecular structures. Conventional calculation of structure requires the use of various software packages, considerable user expertise and ample computational resources. To facilitate the use of NMR spectroscopy and SAXS in life sciences the WeNMR consortium has established standard computational workflows and services through easy-to-use web interfaces, while still retaining sufficient flexibility to handle more specific requests. Thus far, a number of programs often used in structural biology have been made available through application portals. The implementation of these services, in particular the distribution of calculations to a Grid computing infrastructure, involves a novel mechanism for submission and handling of jobs that is independent of the type of job being run. With over 450 registered users (September 2012), WeNMR is currently the largest Virtual Organization (VO) in life sciences. With its large and worldwide user community, WeNMR has become the first Virtual Research Community officially recognized by the European Grid Infrastructure (EGI)

Searches for W′\mathrm{W^\prime} bosons decaying to a top quark and a bottom quark in proton-proton collisions at 13 TeV

Searches are presented for heavy gauge bosons decaying into a top and a bottom quark in data collected by the CMS experiment at $\sqrt{s}$ = 13 TeV that correspond to an integrated luminosity of 2.2 and 2.6 fb$^{-1}$ in the leptonic and hadronic analyses, respectively. Two final states are analyzed, one containing a single electron, or muon, and missing transverse momentum, and the other containing multiple jets and no electrons or muons. No evidence is found for a right-handed W' boson (W'$_R$) and the combined analyses exclude at 95% confidence level W'$_R$ with masses below 2.4 TeV if $M_{{W'}_{R}} \gg M_{{\nu}_{R}}$ (mass of the right handed neutrino), and below 2.6 TeV if $M_{{W'}_{R}} < M_{{\nu}_{R}}$. The results provide the most stringent limits for right-handed W' bosons in the top and bottom quark decay channel

Search for supersymmetry in multijet events with missing transverse momentum in proton-proton collisions at 13 TeV

A search for supersymmetry is presented based on multijet events with large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=$ 13 TeV. The data, corresponding to an integrated luminosity of 35.9$^{-1}$, were collected with the CMS detector at the CERN LHC in 2016. The analysis utilizes four-dimensional exclusive search regions defined in terms of the number of jets, the number of tagged bottom quark jets, the scalar sum of jet transverse momenta, and the magnitude of the vector sum of jet transverse momenta. No evidence for a significant excess of events is observed relative to the expectation from the standard model. Limits on the cross sections for the pair production of gluinos and squarks are derived in the context of simplified models. Assuming the lightest supersymmetric particle to be a weakly interacting neutralino, 95% confidence level lower limits on the gluino mass as large as 1800 to 1960 GeV are derived, and on the squark mass as large as 960 to 1390 GeV, depending on the production and decay scenario

Search for dark matter produced in association with heavy-flavor quark pairs in proton-proton collisions at s=13\sqrt{s}=13 TeV

A search is presented for an excess of events with heavy-flavor quark pairs ( ${t}\overline{{t}}$ and ${b} \overline{{b}}$ ) and a large imbalance in transverse momentum in data from proton–proton collisions at a center-of-mass energy of 13 $\,\text{TeV}$ . The data correspond to an integrated luminosity of 2.2 $\,\text{fb}^{-1}$ collected with the CMS detector at the CERN LHC. No deviations are observed with respect to standard model predictions. The results are used in the first interpretation of dark matter production in ${t}\overline{{t}}$ and ${b} \overline{{b}}$ final states in a simplified model. This analysis is also the first to perform a statistical combination of searches for dark matter produced with different heavy-flavor final states. The combination provides exclusions that are stronger than those achieved with individual heavy-flavor final states

Searches for W′ bosons decaying to a top quark and a bottom quark in proton-proton collisions at 13 TeV

Searches are presented for heavy gauge bosons decaying into a top and a bottom quark in data collected by the CMS experiment at $\sqrt{s}=13$ TeV that correspond to an integrated luminosity of 2.2 and 2.6 fb$^{−1}$ in the leptonic and hadronic analyses, respectively. Two final states are analyzed, one containing a single electron, or muon, and missing transverse momentum, and the other containing multiple jets and no electrons or muons. No evidence is found for a right-handed W′ boson (W′$_{R}$) and the combined analyses exclude at 95% confidence level W′$_{R}$ with masses below 2.4 TeV if ${M}_{\mathrm{W}{\prime}_{\mathrm{R}}}\gg {M}_{\nu_{\mathrm{R}}}$ (mass of the right-handed neutrino), and below 2.6 TeV if ${M}_{\mathrm{W}{\prime}_{\mathrm{R}}}<{M}_{\nu_{\mathrm{R}}}$ . The results provide the most stringent limits for right-handed W′ bosons in the top and bottom quark decay channel

Search for supersymmetry in multijet events with missing transverse momentum in proton-proton collisions at 13 TeV

A search for supersymmetry is presented based on multijet events with large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=$ 13 TeV. The data, corresponding to an integrated luminosity of 35.9 fb$^{-1}$, were collected with the CMS detector at the CERN LHC in 2016. The analysis utilizes four-dimensional exclusive search regions defined in terms of the number of jets, the number of tagged bottom quark jets, the scalar sum of jet transverse momenta, and the magnitude of the vector sum of jet transverse momenta. No evidence for a significant excess of events is observed relative to the expectation from the standard model. Limits on the cross sections for the pair production of gluinos and squarks are derived in the context of simplified models. Assuming the lightest supersymmetric particle to be a weakly interacting neutralino, 95% confidence level lower limits on the gluino mass as large as 1800 to 1960 GeV are derived, and on the squark mass as large as 960 to 1390 GeV, depending on the production and decay scenario

Search for dark matter produced in association with heavy-flavor quarks in proton-proton collisions at sqrt(s)=13 TeV

A search is presented for an excess of events with heavy-flavor quark pairs (ttbar and bbbar) and a large imbalance in transverse momentum in data from proton-proton collisions at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 2.2 inverse femtobarns collected with the CMS detector at the CERN LHC. No deviations are observed with respect to standard model predictions. The results are used in the first interpretation of dark matter production in ttbar and bbbar final states in a simplified model. This analysis is also the first to perform a statistical combination of searches for dark matter produced with different heavy-flavor final states. The combination provides exclusions that are stronger than those achieved with individual heavy-flavor final states