82 research outputs found
Potential benefits of allogeneic bone marrow mesenchymal stem cells for wound healing
Introduction:
It is becoming increasingly evident that select adult stem cells have the capacity to participate in repair and regeneration of damaged and/or diseased tissues. Mesenchymal stem cells have been among the most studied adult stem cells for the treatment of a variety of conditions, including wound healing.
Areas covered:
Mesenchymal stem cell features potentially beneficial to cutaneous wound healing applications are reviewed.
Expert opinion:
Given their potential for in vitro expansion and immune modulatory effects, both autologous and allogeneic mesenchymal stem cells appear to be well suited as wound healing therapies. Allogeneic mesenchymal stem cells derived from young healthy donors could have particular advantage over autologous sources where age and systemic disease can be significant factors
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The potential of bone marrow cells to orchestrate homeostasis and healing in skin
Bone marrow derived cells play a major role in the maintenance and repair of many tissues, mostly by the delivering of a variety of inflammatory cells. Recent evidence however suggests that bone marrow may also supply cellular substrate for rebuilding non-hematopoietic tissues following injury. This discussion addresses the potential role of bone marrow to provide cells to the skin for rebuilding of skin structures following injury and for skin maintenance
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Bone Marrow Adult Stem and Progenitor Cells in the Treatment of Chronic Wounds TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK
Background: A variety of stem cells have captured the attention of the scientific community and lay press. Collectively, these cells have great potential for the repair and regeneration of a variety of tissues. Wound healing has been a primary focus for many recent studies.
The Problem: Chronic wounds represent a failure of the normal mechanisms involved in healing. Even when wounds do heal, the healed area has significant alteration of the normal anatomy predisposing the area to rewounding.
Basic/Clinical Science Advances: Stem and progenitor cells have been shown to reside locally within the skin and traffic to the skin from distant sites, particularly in response to injury. Recent studies have attempted to identify the function of these cells and how they participate in the healing process.
Clinical Care Relevance: The use of bone marrow derived stern and progenitor cells has shown promise in laboratory wound models and in the treatment of recalcitrant chronic wounds in patients.
Conclusion: Adult stem and progenitor cells derived from skin, bone marrow, and other tissues hold great promise for wound healing and tissue regeneration with return of normal function
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An in Vivo Analysis of c-myc and c-fos Expression During Terminal Erythroid Differentiation in Mouse Spleen Progenitors
Toward an 'off the shelf' technology for burn victims: healing wounds with mesenchymal stem cells
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Short-contact topical tretinoin therapy to stimulate granulation tissue in chronic wounds
Growth inhibition of primary keratinocytes following transduction with a novel TGFβ-1 containing retrovirus
Growth and migration of keratinocytes are known to be affected by the addition of exogenous cytokines, such as TGFβ-1, to culture media. We have developed a retroviral vector, LNTβ-1, that confers constitutive expression of human TGFβ-1 to transduced cells. Keratinocytes were exposed to retroviral particles generated in serum-free media, and infected cells were selected for with Geneticin. Transduced keratinocytes remained in culture as single cells instead of a normally grouped growth pattern. While these transduced keratinocytes survived in culture for several weeks, they did not proliferate and seemed arrested in their growth. Keratinocytes transduced with retrovirus not containing the TGFβ-1 gene appeared normal in their growth pattern. These findings indicate that high-level endogenous expression of TGFβ-1 in keratinocytes can at least inhibit, and possibly arrest, growth
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