A unique RET EXON 11 (G691S) polymorphism in an Indian patient with a collision tumor of the thyroid

BACKGROUND: Collision tumors of the thyroid are rare, with occasional reports dealing with their genetic analysis. CASE PRESENTATION: A 59 year old lady presented with a neck mass, associated with hoarseness of voice of 5 years duration. Radiological examination revealed nodular masses in the left lobe of her thyroid, along with one in the isthmus, extending into the right lobe and associated with enlarged neck nodes. FNAC from the left thyroid showed features of medullary carcinoma. On total thyroidectomy, 2 distinct tumor nodules were identified in the left lobe with another in the isthmus, showing features of medullary carcinoma (MTC), papillary carcinoma and follicular variant of papillary carcinoma, respectively, accompanied with nodal metastasis. Subsequently, she underwent radioablation. RET gene analysis of the patient, her 2 daughters and a grandson revealed a unique G691S polymorphism on Exon 11. CONCLUSION: This unique case of a collision tumor of thyroid, including component of an MTC deals with the value of RET gene analysis and therapeutic implications in the index case and in family members

Researchers on ice? How the COVID-19 pandemic has impacted Antarctic researchers

The COVID-19 pandemic and pandemic-related measures have impacted the lives and work-related activities of Antarctic researchers. To explore these impacts, we designed, piloted and disseminated an online survey in English, Russian, Spanish and Chinese in late 2020 and early 2021. The survey explored how the pandemic affected the productivity of Antarctic researchers, their career prospects and their mental wellbeing. Findings exposed patterns of inequities. For instance, of the 406 unique responses to the survey, women appeared to have been affected more adversely than men, especially in relation to mental health, and early-career researchers were disadvantaged more than their mid- or late-career colleagues. Overall, a third of the research participants reported at least one major negative impact from the pandemic on their mental health. Approximately half of the participants also mentioned that the COVID-19 pandemic had some positive effects, especially in terms of the advantages that working from home brought and opportunities to attend events, network or benefit from training workshops online. We conclude with a series of recommendations for science administrators and policymakers to mitigate the most serious adverse impacts of the pandemic on Antarctic research communities, with implications for other contexts where scientific activities are conducted under extreme circumstances

Extraction, Characterization and Evaluation of Okara Mucilage

Mucilage is the thick, gluey substances produced by nearly all plant and some microorganisms. Okra mucilage is extracted from the plant of the malavaceae [A. esculantus]. Which is originally from Egypt, but it also in cropped in southern Asia elsewhere for nutritional purposes. Their use as potential reinforcement in polymer composites requires the understanding of their microstructure and mechanical properties. This work investigates the extraction methods, solubility behavior, TLC, loss on drying, ash value, FTIR spectra, surface tension, organoleptic properties. Extracted mucilage is soluble in warm water while insoluble in organic solvents. This can shows that it safely used in dosage form without causing any adverse effect. Keywords: Okara Mucilage, Pharmaceutical Excipients, Controlled-Release Formulatio

Project and Community Management in Polar Sciences – Challenges and Opportunities

Because geoscientific research often occurs via community-instigated bursts of activity with multi-investigator collaborations variously labelled as e.g., years (The International Polar Year IPY), experiments (World Ocean Circulation Experiment WOCE), programs (International Ocean Discovery Program), missions (CRYOSAT spacecraft), or decades (The International Decade of Ocean Exploration IDOE), successful attainment of research goals generally requires skilful scientific project management. In addition to the usual challenges of matching scientific ambitions to limited resources, on-going coordination and specifically project management, planning and implementation of polar science projects often involve many uncertainties caused by, for example, unpredictable weather or ocean and sea ice conditions, large-scale logistical juggling; and often these collaborations are spatially distributed and take place virtually. Large amounts of funding are needed to procure the considerable infrastructure and technical equipment required for polar expeditions; permissions to enter certain regions must be requested; and potential risks for expedition members as well as technical issues in extreme environments need to be considered. All these aspects are challenging for polar science projects, which therefore need a well thought-through program including a realistic alternative “plan B” and possibly also a “plan C” and “plan D”. The four most challenging overarching themes in polar science project management have been identified: international cooperation, interdisciplinarity, infrastructure, and community management. In this paper, we address ongoing challenges and opportunities in polar science project management based on a survey among 199 project and community managers and an additional of 85 project team members active in the field of polar sciences. Case studies and survey results are discussed with the conclusive goal to provide recommendations on how to fully reach the potential of polar sciences project and community management

Uncemented and cemented primary total hip arthroplasty in the Swedish Hip Arthroplasty Register: Evaluation of 170,413 operations

BACKGROUND AND PURPOSE: Since the introduction of total hip arthroplasty (THA) in Sweden, both components have most commonly been cemented. A decade ago the frequency of uncemented fixation started to increase, and this change in practice has continued. We therefore analyzed implant survival of cemented and uncemented THA, and whether the modes of failure differ between the two methods of fixation. PATIENTS AND METHODS: All patients registered in the Swedish Hip Arthroplasty Register between 1992 and 2007 who received either totally cemented or totally uncemented THA were identified (n = 170,413). Kaplan-Meier survival analysis with revision of any component, and for any reason, as the endpoints was performed. Cox regression models were used to calculate risk ratios (RRs) for revision for various reasons, adjusted for sex, age, and primary diagnosis. RESULTS: Revision-free 10-year survival of uncemented THA was lower than that of cemented THA (85% vs. 94%, p < 0.001). No age or diagnosis groups benefited from the use of uncemented fixation. Cox regression analysis confirmed that uncemented THA had a higher risk of revision for any reason (RR = 1.5, 95% CI: 1.4-1.6) and for aseptic loosening (RR = 1.5, CI: 1.3-1.6). Uncemented cup components had a higher risk of cup revision due to aseptic loosening (RR = 1.8, CI: 1.6-2.0), whereas uncemented stem components had a lower risk of stem revision due to aseptic loosening (RR = 0.4, CI: 0.3-0.5) when compared to cemented components. Uncemented stems were more frequently revised due to periprosthetic fracture during the first 2 postoperative years than cemented stems (RR = 8, CI: 5-14). The 5 most common uncemented cups had no increased risk of revision for any reason when compared with the 5 most commonly used cemented cups (RR = 0.9, CI: 0.6-1.1). There was no significant difference in the risk of revision due to infection between cemented and uncemented THA. INTERPRETATION: Survival of uncemented THA is inferior to that of cemented THA, and this appears to be mainly related to poorer performance of uncemented cups. Uncemented stems perform better than cemented stems; however, unrecognized intraoperative femoral fractures may be an important reason for early failure of uncemented stems. The risk of revision of the most common uncemented cup designs is similar to that of cemented cups, indicating that some of the problems with uncemented cup fixation may have been solved.Open Access - This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited

Polar Research Education, Outreach and Communication during the fourth IPY: How the 2007–2008 International Polar Year has contributed to the future of education, outreach and communication.

One year after the launch of the International Polar Year (IPY) Education, Outreach and Communication (EOC) Assessment Project the task of inventorying and investigating the hundreds of IPY EOC programmes that occurred during the IPY 2007-08 is now complete. Supported by APECS, IASC and SCAR, this ICSU funded project is the only global examination of what happened in outreach during IPY. The latest IPY event was one of the most ambitious polar research programmes to date, tens of thousands of scientists and students participated, but IPY also set out to involve members of the general public in active polar science endeavours on a global scale. How successful was this part of the IPY plan? With over 550 IPY EOC activities, from more than 70 countries in 25 languages IPY EOC is one of the largest global investments in science outreach to date. The IPY EOC Assessment brought together educators, communications personnel and researchers and the resulting report examines the success of IPY EOC efforts, and discusses why IPY EOC was able to reach its goals and beyond. From the experience of IPY, the report also outlines a set of lessons learned on how to improve science outreach across a variety of disciplines. These lessons will be useful for other science outreach projects - large or small - regional, national or international. IPY EOC went to new heights, depths and extremes to take people to the poles and to take the poles to the people. Now the legacy of IPY outreach is helping to shape the future of science education and outreach. You can also search the online Polar Outreach Catalogue - a growing inventory of these IPY projects and new outreach efforts to help educate the world about the global importance of the polar regions. http://apecs.is/education-outreach/catalogu

Southern Ocean Action Plan (2021-2030) in support of the United Nations Decade of Ocean Science for Sustainable Development

In 2017, the United Nations proclaimed a Decade of Ocean Science for Sustainable Development (hereafter referred to as the UN Ocean Decade) from 2021 until 2030 to support efforts to reverse the cycle of decline in ocean health. To achieve this ambitious goal, this initiative aims to gather ocean stakeholders worldwide behind a common framework that will ensure ocean science can fully support countries in creating improved conditions for sustainable development of the world’s oceans. The initiative strives to strengthen the international cooperation needed to develop the scientific research and innovative technologies that can connect ocean science with the needs of society at the global scale. Based on the recommendations in the Implementation Plan of the United Nations Decade of Ocean Science for Sustainable Development (Version 2.0, July 2021), the Southern Ocean community engaged in a stakeholder - oriented process to develop the Southern Ocean Action Plan. The Southern Ocean process engaged a broad community, which includes the scientific research community, the business and industry sector, and governance and management bodies. As part of this global effort, the Southern Ocean Task Force identified the needs of the Southern Ocean community to address the challenges related to the unique environmental characteristics and governance structure of the Southern Ocean. Through this community-driven process, we identified synergies within the Southern Ocean community and beyond in order to elaborate an Action Plan that provides a framework for Southern Ocean stakeholders to formulate and develop tangible actions and deliverables that support the UN Ocean Decade vision. Through the publication of this Action Plan, the Southern Ocean Task Force aims to mobilise the Southern Ocean community and inspire all stakeholders to seek engagement and leverage opportunities to deliver innovative solutions that maintain and foster the unique conditions of the Southern Ocean. This framework provides an initial roadmap to strengthen links between science, industry and policy, as well as to encourage internationally collaborative activities in order to address existing gaps in our knowledge and data coverage