6 research outputs found
Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum
Metabolite channeling by a dynamic metabolon
The specialized metabolite dhurrin breaks down into cyanide when plant cell walls have been chewed, deterring insect pests. Laursen
et al.
found that the enzymes that synthesize dhurrin in sorghum assemble as a metabolon in lipid membranes (see the Perspective by Dsatmaichi and Facchini). The dynamic nature of metabolon assembly and disassembly provides dhurrin on an as-needed basis. Membrane-anchored cytochrome P450s cooperated with a soluble glucosyltransferase to channel intermediates toward efficient dhurrin production.
Science
, this issue p.
890
; see also p.
829
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