Endogenous Skin Fluorescence is a Good Marker for Objective Evaluation of Comedolysis

Objective evaluation of comedone lesions, especially in vivo, remains a challenge. We have used the rhino mouse model in combination with topical application of all-trans retinoic acid as a comedolytic agent, to investigate the potential of fluorescence spectroscopy as a noninvasive technique in the assessment of noninflammatory acne. The results indicate that there is a strong correlation between the fluorescence excitation spectral features assessed in vivo, and the histologic changes identified, particularly the size of the utriculi as well as the dermal and epidermal thickness. We conclude that fluorescence excitation spectroscopy represents a promising novel and useful tool in the quantitative evaluation of the pseudocomedones and could also be used for the rapid and noninvasive assessment of comedolysis induced by the application of pharmacologic agents such as retinoids

Contribution to the study of the factors influencing Maillard reaction with dihydroxyacetone in order to induce cutaneous pigmentation

PARIS-BIUP (751062107) / SudocSudocFranceF

The impact of agricultural growth on the rural development in Vietnam

Rural development is a global relevant phenomenon that needs the particular attention of researchers as well as regulators to achieve the development goals it entails. Considering this, the present study investigates the impact of agriculture growth, agricultural employment and import and rural population growth on rural development in Vietnam. This study is conducted based on the secondary data extracted from World Development Indicators (WDI) from 1981 to 2018. This study executes the Autoregressive Distributed Lag (ARDL) model to investigate the nexus among the variables. The results show that agriculture growth, agricultural employment and import and rural population growth have a positive nexus with rural development in Vietnam. This study offers valuable insights for rural area development authorities and policy experts to help formulate effective and responsive policies to promote agricultural growth and develop rural societies.Dinh Hong Linh (Thai Nguyen University of Economics and Business Administration, Thai Nguyen, Viet Nam), Nguyen Thi Thu Cuc* (Vinh University, Vinh City, Viet Nam), Nguyen Cong Tiep (Viet Nam National University of Agriculture, Ha Noi, Viet Nam), Nguyen Xuan Diep (Thai Nguyen University of Economics and Business Administration, Thai Nguyen, Viet Nam), Vu Bach Diep (Thai Nguyen University of Economics and Business Administration, Thai Nguyen, Viet Nam), Kwak Busung (Thai Nguyen University of Economics and Business Administration, Thai Nguyen, Viet Nam), Nguyen Nang Hung (Vinh University, Vinh City, Viet Nam)Includes bibliographical reference

The effects of risks in agricultural supply chain management on business performance : a case study in Vietnam

Risks in the agricultural supply chain management can cause significant losses to the production and business activities of enterprises in the market. This study aims to examine the impact of risks in the agricultural supply chain management on the business performance of enterprises. Applying a quantitative research method through SEM linear structure model analysis, with survey data size including 625 samples of managers who have experience and knowledge of agricultural supply chain operations management in enterprises in Vietnam. Research results show that risks in the supply chain have both direct and indirect effects on business performance through intermediaries, which are trust and linkages in the agricultural supply chain management. Besides, research also shows that there is a negative impact from the trust of participants and linkages in the agricultural supply chain management on the business performance of enterprises. In addition, research has also demonstrated that links positively affect both trust and opportunistic behavior of the participants in the agricultural supply chain management. On that basis, the study has given several recommendations to improve business performance for enterprises. The findings of this study have shown the importance and impact of risks in the agricultural supply chain management in multiple dimensions and aspects of business performance.Quang Bach Tran (Faculty of Economics, Vinh University (VU), Vietnam), Thi Thu Cuc Nguyen* (Corresponding Author, Faculty of Economics, Vinh University (VU), Vietnam, [Postal Address: 182 Le Duan, Ben Thuy, Vinh City, Nghe An, Vietnam]), Thi Minh Phuong Nguyen (Lecture, Faculty of Economics, Vinh University (VU), Vietnam), Dieu Linh Tran (Lecture, Faculty of Economics, Vinh University (VU), Vietnam), Anh Tuan Nguyen (PhD Candidate, Economic Department, Vinh University (VU), Vietnam), Quang Tai Dang (PhD Candidate, Economic Department, Vinh University (VU), Vietnam)Includes bibliographical reference

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer.

Head and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the deadliest and the most disfiguring cancers globally. Oral cancer (OC) constitutes a subset of head and neck cancer cases, presenting primarily as tobacco- and alcohol-associated oral squamous cell carcinoma (OSCC), with a 5-year survival rate of ~ 65%, partly due to the lack of early detection and effective treatments. OSCC arises from premalignant lesions (PMLs) in the oral cavity through a multi-step series of clinical and histopathological stages, including varying degrees of epithelial dysplasia. To gain insights into the molecular mechanisms associated with the progression of PMLs to OSCC, we profiled the whole transcriptome of 66 human PMLs comprising leukoplakia with dysplasia and hyperkeratosis non-reactive (HkNR) pathologies, alongside healthy controls and OSCC. Our data revealed that PMLs were enriched in gene signatures associated with cellular plasticity, such as partial EMT (p-EMT) phenotypes, and with immune response. Integrated analyses of the host transcriptome and microbiome further highlighted a significant association between differential microbial abundance and PML pathway activity, suggesting a contribution of the oral microbiome toward PML evolution to OSCC. Collectively, this study reveals molecular processes associated with PML progression that may help early diagnosis and disease interception at an early stage

Factors associated with food safety compliance among street food vendors in Can Tho city, Vietnam: Implications for intervention activity design and implementation

Background Street food plays a valuable role in several Asian countries including Vietnam. Improving the safety of street food is an important responsibility for many local food authorities. This study aims to characterize the business profile of fixed and mobile street food vendors, and to compare their compliance with the food safety criteria. Methods A cross-sectional study was conducted using a questionnaire and observational checklist to assess the ten Vietnamese food safety criteria prescribed under Decision No. 3199/2000/QD-BYT for street food vendors in Can Tho city. A total of 400 street food vendors, composed of fixed and mobile vendors, in urban areas of the city were randomly selected for the survey. Results The study showed significant differences between the two types of street food vendors in educational level (p = 0.017); business profile, including types of foods vended, area in use, number of employees, training in food safety, and business registration paperwork; and the status of compliance with the ten-food hygiene and safety criteria (p < 0.01). Poisson regression analysis found that education attainment (IRR = 1.228, p = 0.015), food safety training (IRR = 4.855, p < 0.01), total business capital (IRR = 1.004, p = 0.031) and total area in use (IRR = 1.007, p = 0.001) appeared to be significantly positively associated with food safety and hygiene compliance. In contrast, mobile vending type was negatively associated with the likelihood of adhering to the ten criteria (IRR = 0.547, p = 0.005). Conclusions These findings emphasize the need for training and education programs to improve food safety knowledge and practice among street food vendors. Basic infrastructure and services, especially clean water, proper sanitation, and waste disposal facilities, should be provided to help street food vendors better practice food safety and hygiene regulations

Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer

Abstract Head and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the deadliest and the most disfiguring cancers globally. Oral cancer (OC) constitutes a subset of head and neck cancer cases, presenting primarily as tobacco- and alcohol-associated oral squamous cell carcinoma (OSCC), with a 5-year survival rate of ~ 65%, partly due to the lack of early detection and effective treatments. OSCC arises from premalignant lesions (PMLs) in the oral cavity through a multi-step series of clinical and histopathological stages, including varying degrees of epithelial dysplasia. To gain insights into the molecular mechanisms associated with the progression of PMLs to OSCC, we profiled the whole transcriptome of 66 human PMLs comprising leukoplakia with dysplasia and hyperkeratosis non-reactive (HkNR) pathologies, alongside healthy controls and OSCC. Our data revealed that PMLs were enriched in gene signatures associated with cellular plasticity, such as partial EMT (p-EMT) phenotypes, and with immune response. Integrated analyses of the host transcriptome and microbiome further highlighted a significant association between differential microbial abundance and PML pathway activity, suggesting a contribution of the oral microbiome toward PML evolution to OSCC. Collectively, this study reveals molecular processes associated with PML progression that may help early diagnosis and disease interception at an early stage. Graphical abstrac

A study of the impact of an interprofessional education module in Vietnam on students' readiness and competencies

Abstract: Introduction: The literature puts forward a range of challenges of interprofessional education (IPE) related to its planning, initiation, implementation, and especially to IPE assessment. The present study aims to map changes in students\u2019 readiness and interprofessional collaboration competence (IPCC) in implementing an innovative IPE module. Potential differences in impact related to the health education programs and IPCC scores resulting from self-, peer-, and tutor assessments will also be analysed. Methods: A pre-post design was adopted. The student\u2019s readiness for interprofessional learning was assessed using the Readiness for Interprofessional Learning Scale, and the student\u2019s IPCC score was calculated based on self-, peer-, and tutor assessments with the interprofessional collaborator assessment rubric. Results: Students\u2019 mean post-test readiness scores and mean post-test IPCC scores were significantly higher than the total and subscales/domain pre-test scores (p<0.01). No significant within-subject differences were observed in students\u2019 readiness total or subscale scores when comparing health educational programs. However, significant differences were observed in students\u2019 mean total IPCC scores between programs (p<0.01). Significant differences in students\u2019 average IPCC scores were found when comparing self-, peer- and tutor assessment scores in six domains (p<0.01). Also, significant correlations between peer and tutor assessment scores were observed (p<0.01). Conclusion: The IPE module, designed and implemented to focus on patient-centred practice within a primary care context, positively impacted students\u2019 readiness and IPCC development. These results offer insights to expand the implementation of the IPE module to all health educational programs

A study of the impact of an interprofessional education module in Vietnam on students’ readiness and competencies

Introduction The literature puts forward a range of challenges of interprofessional education (IPE) related to its planning, initiation, implementation, and especially to IPE assessment. The present study aims to map changes in students' readiness and interprofessional collaboration competence (IPCC) in implementing an innovative IPE module. Potential differences in impact related to the health education programs and IPCC scores resulting from self-, peer-, and tutor assessments will also be analysed. Methods A pre-post design was adopted. The student's readiness for interprofessional learning was assessed using the Readiness for Interprofessional Learning Scale, and the student's IPCC score was calculated based on self-, peer-, and tutor assessments with the interprofessional collaborator assessment rubric. Results Students' mean post-test readiness scores and mean post-test IPCC scores were significantly higher than the total and subscales/domain pre-test scores (p<0.01). No significant within-subject differences were observed in students' readiness total or subscale scores when comparing health educational programs. However, significant differences were observed in students' mean total IPCC scores between programs (p<0.01). Significant differences in students' average IPCC scores were found when comparing self-, peer- and tutor assessment scores in six domains (p<0.01). Also, significant correlations between peer and tutor assessment scores were observed (p<0.01). Conclusion The IPE module, designed and implemented to focus on patient-centred practice within a primary care context, positively impacted students' readiness and IPCC development. These results offer insights to expand the implementation of the IPE module to all health educational programs