2 research outputs found
LC/MS:AN ESSENTIAL TOOL IN DRUG DEVELOPMENT
The combination of high-performance liquid chromatography and mass spectrometry (LC/MS) has had a sign cant impact on drug development over the past decade. Continual improvements in LC/MS interface technologies combined with powerful features for structure analysis, qualitative and quantitative,have resulted in a widened scope of application. These improvements coincided with breakthroughs in combinatorial chemistry, molecular biology, and an overall industry trend of accelerated development.The use of high-performance liquid chromatographycombined with mass spectrometry (HPLC MS) or tandem mass spectrometry (HPLC MS MS) has proven to be the analytical technique of choice for most assays used in various stages of new drug discovery. Asummary of the key components of HPLC MS systems, as well as an overview of major application areas that use this technique as part of the drug discovery process, will be described here. This review will also provide an introduction into the various types of mass spectrometers that can be selected for the multiple tasks that can be performed using LC MS as the analytical tool. The strategies for optimizing the use of this technique and also the potential problems and how to avoid them will be highlighted
Vesicular Drug Delivery System -An Over View
ABSTRACT The application of vesicular system in drug delivery has changed the definitions of diagnosis and treatment in different aspects of biomedical field. The vesicular system as liposome's, niosomes, sphinosomes, transferosomes, pharmacosomes and ufasomes are used to improve the new drug molecules by encapsulating an active medicament inside vesicular structure in one such system. It prolongs the existence of the drug in systemic circulation and finally reduces the toxicity. Such different systems are widely used in gene delivery, tumor targeting to brain, oral formulations, in stability and permeability problems of drugs. In this review we really focused on different aspects of vesicular system in terms of its advantages, limitation, applications and different marketed product of vesicular system as novel drug delivery