A Study of Students’ English Listening and Speaking Proficiency through Developmentally Appropriate Practices at Kirakira Kids International Kindergarten, Bangkok, Thailand

This study compared the progressive scores of the English listening proficiency and ENGLISH-SPEAKING proficiency of students at Kirakira Kids International Kindergarten. The progressive scores were based on observational notes of K3 students that they researcher took with a team-teacher. The collection of data was over a period of three months (April 27 to May 31, 2015; June 2015; and July 2015). The study had four research objectives: 1) to identify the students’ demographic data (age, amount of years spent in the school previously, and background in English) at Kirakira Kids International Kindergarten 2) to determine the progressive scores of the students’ English listening proficiency at Kirakira Kids International Kindergarten 3) to determine the progressive scores of the students’ English speaking proficiency at Kirakira Kids International Kindergarten, 4) to compare the difference between the students’ English listening and speaking proficiency at Kirakira Kids International Kindergarten.The population and sample size for this research study was 40 students of the K3 class. The researcher used student records to obtain the data needed to address research objective one. The researcher analyzed the data obtained from the student records using numbers and percentage. For the findings of research objective two and three, the researcher used observational notes and progressive scores from April 27 to May 31, 2015; June 2015; and July 2015. The researcher analyzed the progressive scores using means and standard deviation to present and report the findings. For the findings of research objective four, the researcher used a paired-samples two-tailed t-test to compare the difference between the students’ English listening proficiency and the ENGLISH-SPEAKING proficiency

Knowledge and attitude toward theranostics among Nuclear Medicine Technologists

This study was conducted to determine the knowledge and attitude of nuclear medicine technologists toward theranostics. This research utilized a quantitative correlational research design. Data were gathered from 69 practicing nuclear medicine technologists, specifically those that do not perform or have theranostics procedures. The data were gathered using a self-made questionnaire and statistically treated using frequency, percentage, range, mean, standard deviation, t-test, ANOVA, Kruskal-Wallis H test, Mann-Whitney U test, and Spearman Rank Order Correlation. Findings show that the majority of the respondents are male, and most are 20-30 years old. Most of the respondents have good knowledge and show a “positive attitude” toward theranostics. In general, there are no significant differences in the knowledge of the respondents about theranostics when they are grouped according to sex, years of experience and type of hospital they are currently employed in. However, there is a significant difference when grouped according to age, where the 31–40-year-old group showed a higher level of knowledge than the 20-30-year-old group possibly due to learning more about practices with theranostics. With the respondents’ attitude toward theranostics, there are no significant differences when they are grouped according to age, sex, years of experience, and type of hospital they are currently employed in. The findings also show that there is a weak positive relationship between the knowledge and attitude of the respondents toward theranostics. Generally, the results show that nuclear medicine technologists have very good attitude toward and good knowledge of theranostics

C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo

Histone deacetylase inhibitors (HDACIs) have shown promising anti-tumor effects for a variety of malignancies, however, many tumors are reportedly resistant to them. In this study, we made a novel discovery that co-administration of HDACIs (Trichostatin A (TSA) and others) and exogenous cell-permeable short-chain ceramide (C6) results in striking increase in cancer cell death and apoptosis in multiple cancer cells. These events are associated with perturbations in diverse cell signaling pathways, including inactivation of Akt/mTOR and increase in α-tubulin acetylation (both in vivo and in vitro). TSA interacts in a highly synergistic manner with C6-ceramide to disrupt HDAC6/protein phosphatase 1 (PP1)/tubulin complex, to induce α-tubulin hyperacetylation, and to release and activate PP1, which then leads to AKT dephosphorylation and eventually causes cancer cell death. Interestingly, TSA itself results in short-term ceramide accumulation, which as a result of metabolic (glycosylation) removal, does not result in evident increase of cancer cell death. However, adding C6-ceramide led to a very pronounced increase in ceramide level and marked increase in cell death. Importantly, the effective synergistic anti-tumor activity of TSA plus C6-ceramide is also seen in in vivo mice xenograft pancreatic and ovarian cancer models, indicating that this regimen (HDACI plus C6-ceramide) may represent a more effective form of therapy against pancreatic and ovarian carcinoma

Manifiesto jurídico por el reverendo Joseph Babia, presbitero y retor de la iglesia parroquial del castillo de Ciurana, obispado de Gerona, en que se manifiesta ser acreedor al primer lugar en la informacion ... sobre los pretendientes del beneficio segundo, baxo la invocacion de San Estevan, por Raymundo Alvertí, en la Santa Iglesia de la misma ciudad ...

Encartament a la part interior de la coberta posterior: "Fee de erratas". -- Sign.: A-D2. -- Reclams. -- Sense enq

The use of fluorescent lipid analogs to study endocyto¬sis of glycosphingolipids

Babia T, Kok JW and Hoekstra D