1 research outputs found
Clinical application of induced sputum in children with newly diagnosed asthma: cellular and immunologic characteristics
Authors investigate cells and immunologic factors of induced sputum in children with newly diagnosed asthma and healthy children without atopy. The aim of the study was to find out the differences of cellular and immunologic profiles of induced sputum in children with newly diagnosed asthma. 35 children aged 1,5-5 years old (Me = 3,5 years) were include in this study: 18 children with newly diagnosed asthma and 17 children (control group) without allergic diseases, which had no respiratory symptoms during last month. Sputum induction carried out according to our modification of protocol developed by Pin et al. The levels of IgE, slgA, lgG4, IL-1Ξ², IL-4, IL-8, IL-13, TNFΞ±, INFΞ³, N03, NOX and cells percentage (macrophages, neutrophils, eosinophils, lymphocytes) were evaluated in sputum. Results. The percentage of eosinophils was significantly higher and the percentage of macrophages was significantly lower in induced sputum of children with newly diagnosed asthma. The levels of proinflammatory factors (IL-1Ξ², IL-4, IL-8, IL-13, TNFΞ±), immunoglobulins, which participate in allergic inflammation (IgE, slgA, lgG4) and stable metabolites of NO (NO3, NOX) in sputum were also significantly higher in children with newly diagnosed asthma.ΠΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ ΠΏΠΎΠ΄ΡΡΠ΅Ρ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π² ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠΊΡΠΎΡΠ΅ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π²ΠΏΠ΅ΡΡΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π±Π΅Π· Π°ΡΠΎΠΏΠΈΠΈ. Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠΊΡΠΎΡΡ Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΈΠ½ΡΠ»ΠΈ ΡΡΠ°ΡΡΠΈΠ΅ 35 Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 1,5-5 Π»Π΅Ρ (ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ 3,5Π³.): 18 Π΄Π΅ΡΠ΅ΠΉ Ρ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ ΠΈ 17 ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π±Π΅Π· Π°ΡΠΎΠΏΠΈΠΈ - ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½Π°Ρ Π³ΡΡΠΏΠΏΠ°. Π£ Π²ΡΠ΅Ρ
Π΄Π΅ΡΠ΅ΠΉ Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΠΌΠ΅ΡΡΡΠ° Π½Π΅ Π±ΡΠ»ΠΎ Π·Π°ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΠΏΠΈΠ·ΠΎΠ΄ΠΎΠ² ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΠ½Π΄ΡΠΊΡΠΈΡ ΠΌΠΎΠΊΡΠΎΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΏΠΎ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌΡ Π½Π°ΠΌΠΈ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΡΡΠ²ΠΎΡΠ° Ρ
Π»ΠΎΡΠΈΠ΄Π° Π½Π°ΡΡΠΈΡ. ΠΡΠΎΡΠΎΡΠΈΠΏΠΎΠΌ ΡΠ²ΠΈΠ»ΡΡ ΠΌΠ΅ΡΠΎΠ΄, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ Pin et al., ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΡΡ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠΎΡΡΠ°Π² (%) (ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΈ, Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»Ρ, ΡΠΎΠ·ΠΈΠ½ΠΎΡΠΈΠ»Ρ, Π»ΠΈΠΌΡΠΎΡΠΈΡΡ) ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠΎΡΠΈΠ»Ρ (IgE, slgA, lgG4, IL-1Ξ², IL-4, IL-8, IL-13. TNFΞ±, INFΞ³, NO3, NOX) ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠΊΡΠΎΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π΄Π΅ΡΠ΅ΠΉ Ρ Π²ΠΏΠ΅ΡΠ²ΡΠ΅ Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠΉ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ Π² ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΌΠΎΠΊΡΠΎΡΠ΅ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠΎΠ·ΠΈΠ½ΠΎΡΠΈΠ»ΠΎΠ² (%) Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅, Π° ΡΡΠΎΠ²Π΅Π½Ρ ΠΌΠ°ΠΊΡΠΎΡΠ°Π³ΠΎΠ² (%) Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π½ΠΈΠΆΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ Π΄Π΅ΡΡΠΌΠΈ Π±Π΅Π· Π°ΡΠΎΠΏΠΈΠΈ. Π’Π°ΠΊ ΠΆΠ΅ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠΎΠΉ Π²ΡΡΠ²Π»Π΅Π½Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΏΡΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ² (Π€ΠΠΠ°, ΠΠ 4, IL-1B, ΠΠ8, ΠΠ 13), ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ² (IgE, lgG4) ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ
Π² Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΏΡΠΈ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΠ΅ ΠΈ ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ° (NO3, NOX) ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π±Π΅Π· Π°ΡΠΎΠΏΠΈΠΈ