47 research outputs found
Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
Hematopoietic stem and progenitor cells (HSPCs) are responsible for the production of blood and immune cells. Throughout life, HSPCs acquire oncogenic aberrations that can cause hematological cancers. Although molecular programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool remain poorly characterized. Here, we show that HSPCs constitutively present antigens via major histocompatibility complex class II. The presentation of immunogenic antigens, as occurring during malignant transformation, triggers bidirectional interactions between HSPCs and antigen-specific CD4(+4) T cells, causing stem cell proliferation, differentiation, and specific exhaustion of aberrant HSPCs. This immunosurveillance mechanism effectively eliminates transformed HSPCs from the hematopoietic system, thereby preventing leukemia onset. Together, our data reveal a bidirectional interaction between HSPCs and CD4(+4) T cells, demonstrating that HSPCs are not only passive receivers of immunological signals but also actively engage in adaptive immune responses to safeguard the integrity of the stem cell pool
The Design and Engineering of Mobile Data Services: Developing an Ontology Based on Business Model Thinking
Dienstleistung der Zukunft Maerkte, Unternehmen und Infrakstrukturen im Wandel. Ergebnisse der Tagung des BMBF
With 3,5'' disketteSIGLEAvailable from TIB Hannover: T96B1252 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman
Dienstleistungen - Innovation fuer Wachstum und Beschaeftigung Herausforderungen des internationalen Wettbewerbs
With CD-ROMAvailable from TIB Hannover: T99B2291+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman
Dienstleistung 2000plus. Bd. 1: Zukunftsreport Dienstleistungen in Deutschland
Published in 6 volumesAvailable from TIB Hannover: QN 304(1) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman
Dienstleistung 2000plus. Bd. 6: Arbeitsgruppen und Expertisen
Published in 6 volumesAvailable from TIB Hannover: QN 304(6) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman
Dienstleistung 2000plus. Bd. 3: Neue Maerkte und intelligente Produkte
Published in 6 volumesSIGLEAvailable from TIB Hannover: QN 304(3) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman
Dienstleistung 2000plus. Bd. 2: Grundlagen der Dienstleistungsentwicklung
Published in 6 volumesAvailable from TIB Hannover: QN 304(2) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman