Metabolic and haemodynamic effects of increased circulating adrenaline in man. Effect of labetalol, an alpha and beta blocker.

To simulate increased sympathoadrenal activity adrenaline was infused in normotensive subjects to achieve plasma adrenaline concentrations similar to those seen after myocardial infarction or hypoglycaemia. Adrenaline was infused after pretreatment for five days with labetalol 200 mg twice daily or placebo given in a random order. The rise in systolic blood pressure and the fall in diastolic blood pressure observed after the infusion of adrenaline (0.06 micrograms/kg/min) were prevented by labetalol and no increase in blood pressure was seen. Adrenaline infusion after pretreatment with placebo caused a profound fall in the serum potassium concentration (4.12-3.20 mmol(mEq)/l). Pretreatment with labetalol completely blocked adrenaline induced hypokalaemia (3.92-3.95 mmol(mEq)/l). Adrenaline induced T wave flattening and QTc prolongation were also prevented by labetalol. Thus labetalol can prevent the electrocardiographic, haemodynamic, and hypokalaemic effects of increased circulating adrenaline in man. The combination of alpha and beta blockade appears to be required to block the haemodynamic effects of adrenaline, and labetalol may, therefore, be useful in controlling both the metabolic and circulatory responses during increased sympathoadrenal activity

Ingestão de alimentos e adequação de nutrientes no final da infância Food intake and nutritional adequacy in final phase of childhood

Este trabalho reúne informações sobre a ingestão de alimentos e a adequação dos nutrientes no período final da infância. O grupo estudado foi composto por 247 escolares, sendo 150 do sexo feminino e 97 do masculino, com idade de nove e dez anos, pertencentes a escolas públicas municipais de Maceió. Os dados sobre ingestão de alimentos foram coletados através do recordatório de 24 horas e comparados com as recomendações preconizadas pelo National Research Council de 1989. De acordo com os resultados, a ingestão alimentar dos escolares apresentou-se deficiente em relação à energia e aos micronutrientes, especialmente as vitaminas e alguns minerais pesquisados, com exceção do ferro. Essa deficiência foi encontrada independente do sexo. Tais achados sugerem que o aporte insuficiente dos nutrientes estudados, se persistente, poderá contribuir negativamente para o desempenho do crescimento linear durante a fase da adolescência.<br>This study analyzes the results of a dietary intake survey. The main goal was to estimate the nutrient and energy intake of children in final phase of childhood and the nutritional adequacy of their diet. The studied group was composed of 247 schoolchildren (150 females and 97 males, aged nine to ten years old) from public schools of the city of Maceió, state of Alagoas. Food intake data were collected through a 24-hour dietary recall and compared with the standards of National Research Council-Recommended Dietary Allowances (RDA, 1989). According to the results, the children food intake, independently of the sex, was deficient in energy and micronutrients, specially vitamins and some minerals, with the exception of iron. These findings suggest that in this group specific nutrients deficits can be a limiting factor which may contribute to an inadequate growth performance during adolescence

The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation.

Increased global connectivity has catalyzed technological development in almost all industries, in part through the facilitation of novel collaborative structures. Notably, open innovation and crowd-sourcing-of expertise and/or funding-has tremendous potential to increase the efficiency with which biomedical ecosystems interact to deliver safe, efficacious and affordable therapies to patients. Consequently, such practices offer tremendous potential in advancing development of cellular therapies. In this vein, the CASMI Translational Stem Cell Consortium (CTSCC) was formed to unite global thought-leaders, producing academically rigorous and commercially practicable solutions to a range of challenges in pluripotent stem cell translation. Critically, the CTSCC research agenda is defined through continuous consultation with its international funding and research partners. Herein, initial findings for all research focus areas are presented to inform global product development strategies, and to stimulate continued industry interaction around biomanufacturing, strategic partnerships, standards, regulation and intellectual property and clinical adoption