Voltammetric oxidation of ambroxol and application to its determination in pharmaceuticals and in drug dissolution studies

A detailed study of the electrochemistry of ambroxol at a glassy carbon electrode was carried out in the pH range 1.8 - 11.0 in aqueous solution using cyclic and differential pulse voltammetry. The compound was oxidized irreversibly at high positive potentials resulting in the formation of a chemical product at less positive potentials, which was more readily oxidized than the parent compound. In addition, a differential pulse voltammetric method was proposed for the determination of the drug in different pharmaceutical formulations, and in drug dissolution studies