16 research outputs found
VIRUS TITRES AND PERSISTENTLY RAISED WHITE CELL COUNTS IN CEREBROSPINAL FLUID IN MICE AFTER PERIPHERAL INFECTION WITH DEMYELINATING SEMLIKI FOREST VIRUS
AMS measurements to study uptake and distribution of [sup]26 Al in mice and the role of the transferrin receptor in aluminium absorption mechanisms
Distribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat.
BACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated