1 research outputs found
Death in hospital following ICU discharge: insights from the LUNG SAFE study
- Author
- Aage Christiansen
- Aaron Venti
- Abdellatif Benslama
- Adam B Schlichting
- Adenilton M Rampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Ahmed S Al Jabbary
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandre Demoule
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alistair Nichol
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amanda Krstevski
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Ana Carolina P Antônio
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andres Esteban
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- Angela Delsing
- Aniko D Frigyik
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio G Jimenez
- Antonio L Ruiz-Aguilar
- Antonio Pesenti
- Antonio Pesenti
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arthur S Slutsky
- Arvind K Baronia
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Aurelia M Martinho
- Aylin Seven
- B Taylor Thompson
- Bao H Zhu
- Barbara Brunettini
- Barrett T Kitch
- Barry Kennedy
- Basak Ceyda Meco
- Beatriz C Tan
- Bellani Giacomo
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boonsong Patjanasoontorn
- Boris G Villamagua
- BPg Hj Ismail
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlos A Pellegrini
- Carlos S Pereira
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Catalina Forteza
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Cesar Azevedo
- Cesar P Perez
- Charlene Le Moal
- Charles Gomersall
- Christian C Rylander
- Christian Dellera
- Christian M Ramirez-Alfaro
- Christina Whitehead
- Christopher J Scott
- Christopher Nutt
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Claire Reynolds
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Colette Seasman
- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristina M Coxo
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel F McAuley
- Daniel O Beraldo
- Daniel R Crouch
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- David D Llinares Moya
- David W Wrathall
- Deborah M Inskip
- Deeban Ganesan
- Denis Doyen
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman
- Donald A Irvine
- Donall O'Croinin
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce Dector
- Dulce M Dector
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Eduardo Beck
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Elie H Zogheib
- Elisa Estenssoro
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Erika E Borotto
- Erin Nishikawa
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evgeny Grigoriev
- Ewan C Goligher
- Fa C Zhou
- Fabiana Madotto
- Fabien Grelon
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Fanny Klasen
- Farshad Heidari
- Fayez Kheir
- Fayez M Kheir
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe T Martinez
- Ferdinando Raimondi
- Fernando G George
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Francesca Rabboni
- Francesco L Santoli
- Francesco Mojoli
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- Francis Schneider
- Francisca G Cazorla-Barranquero
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- Francois Beloncle
- Frank van Haren
- Frank van Haren
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- Fumihito Ito
- Gabriel Démpaire
- Gabrielle C Hanlon
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- Giacomo Bellani
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- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Gonzalo Navarro
- Gordon Rubenfeld
- Gordon Rubenfeld
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
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- Gustavo A Plotnikow
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- Gyorgy Frendl
- Haibo Qiu
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- Hiroyuki Honda
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- Hua X Wang
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- Sinead C Okane
- Siu-Ming Au
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- T John Trinder
- T Sottiaux
- Tadaaki Takada
- Takeshi Ueda
- Tamas Szakmany
- Tao Yu
- Tarek Dendane
- Teresa Honrubia
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Tie H Qin
- Tim Wenham
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E Mckenna
- Toshikazu Abe
- Trevor W Oetting
- Troy S Browne
- Tài Pham
- Tài Pham
- Ulrich Strauch
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Vanessa M Sales
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Schiavone
- Virginie Lemiale
- Vivek Kakar
- Vladimir Cerny
- Wahid Altaf
- Wajdi Maazouzi
- Waqar Kashif
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Younsuck Koh
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Ángela Algaba
- Ángela González-Salamanca
- Ñ P Nassar Jr
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
ackground: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.
Methods: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments ('treatment limitations'), and the subpopulations with treatment limitations.
Results: 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge.
Conclusions: A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors