4,878 research outputs found
Web-based multimodal graphs for visually impaired people
This paper describes the development and evaluation of Web-based multimodal graphs designed for visually impaired and blind people. The information in the graphs is conveyed to visually impaired people through haptic and audio channels. The motivation of this work is to address problems faced by visually impaired people in accessing graphical information on the Internet, particularly the common types of graphs for data visualization. In our work, line graphs, bar charts and pie charts are accessible through a force feedback device, the Logitech WingMan Force Feedback Mouse. Pre-recorded sound files are used to represent graph contents to users. In order to test the usability of the developed Web graphs, an evaluation was conducted with bar charts as the experimental platform. The results showed that the participants could successfully use the haptic and audio features to extract information from the Web graphs
A crystalline, 2D polyarylimide cathode for ultrastable and ultrafast Li storage
Organic electrode materials are of longâstanding interest for nextâgeneration sustainable lithiumâion batteries (LIBs). As a promising cathode candidate, imide compounds have attracted extensive attention due to their low cost, high theoretical capacity, high working voltage, and fast redox reaction. However, the redox active site utilization of imide electrodes remains challenging for them to fulfill their potential applications. Herein, the synthesis of a highly stable, crystalline 2D polyarylimide (2DâPAI) integrated with carbon nanotube (CNT) is demonstrated for the use as cathode material in LIBs. The synthesized polyarylimide hybrid (2DâPAI@CNT) is featured with abundant Ïâconjugated redoxâactive naphthalene diimide units, a robust cyclic imide linkage, high surface area, and wellâdefined accessible pores, which render the efficient utilization of redox active sites (82.9%), excellent structural stability, and fast ion diffusion. As a consequence, high rate capability and ultrastable cycle stability (100% capacity retention after 8000 cycles) are achieved in the 2DâPAI@CNT cathode, which far exceeds the stateâofâtheâart polyimide electrodes. This work may inspire the development of novel organic electrodes for sustainable and durable rechargeable batteries
Experimental demonstration of a hyper-entangled ten-qubit Schr\"odinger cat state
Coherent manipulation of an increasing number of qubits for the generation of
entangled states has been an important goal and benchmark in the emerging field
of quantum information science. The multiparticle entangled states serve as
physical resources for measurement-based quantum computing and high-precision
quantum metrology. However, their experimental preparation has proved extremely
challenging. To date, entangled states up to six, eight atoms, or six photonic
qubits have been demonstrated. Here, by exploiting both the photons'
polarization and momentum degrees of freedom, we report the creation of
hyper-entangled six-, eight-, and ten-qubit Schr\"odinger cat states. We
characterize the cat states by evaluating their fidelities and detecting the
presence of genuine multi-partite entanglement. Small modifications of the
experimental setup will allow the generation of various graph states up to ten
qubits. Our method provides a shortcut to expand the effective Hilbert space,
opening up interesting applications such as quantum-enhanced super-resolving
phase measurement, graph-state generation for anyonic simulation and
topological error correction, and novel tests of nonlocality with
hyper-entanglement.Comment: 11 pages, 5 figures, comments welcom
Pulmonary stretch receptor activity during partial liquid ventilation in cats with healthy lungs
Aim: To study whether pulmonary stretch receptor (PSR) activity in mechanically ventilated young cats with healthy lungs during partial liquid ventilation (PLV) is different from that during gas ventilation (GV). Methods: In 10 young cats (4.4 +/- 0.4 months, 2.3 +/- 0.3 kg; mean B SD), PSR instantaneous impulse frequency (PSR f(imp)) was recorded from single fibres in the vagal nerve during GV and PLV with perfluorocarbon (30 ml/kg) at increasing positive inspiratory pressures (PIP; 1.2, 1.8, 2.2 and 2.7 kPa), and at a positive end-expiratory pressure of 0.5 kPa. Results: All PSRs studied during GV maintained their phasic character with increased impulse frequency during inspiration during PLV. Peak PSR fimp was lower at PIP 1.2 kPa (p < 0.05) and at PIP 2.7 kPa (p = 0.10) during PLV than during GV, giving a lower number of PSR impulses at these two settings during PLV (p < 0.05). Conclusion: The phasic character of PSR activity is similar during GV and PLV. PSR activity is not higher during PLV than during GV in cats with healthy lungs, indicating no extensive stretching of the lung during PLV. Copyright (C) 2004 S. Karger AG, Basel
Experimental investigation of classical and quantum correlations under decoherence
It is well known that many operations in quantum information processing
depend largely on a special kind of quantum correlation, that is, entanglement.
However, there are also quantum tasks that display the quantum advantage
without entanglement. Distinguishing classical and quantum correlations in
quantum systems is therefore of both fundamental and practical importance. In
consideration of the unavoidable interaction between correlated systems and the
environment, understanding the dynamics of correlations would stimulate great
interest. In this study, we investigate the dynamics of different kinds of
bipartite correlations in an all-optical experimental setup. The sudden change
in behaviour in the decay rates of correlations and their immunity against
certain decoherences are shown. Moreover, quantum correlation is observed to be
larger than classical correlation, which disproves the early conjecture that
classical correlation is always greater than quantum correlation. Our
observations may be important for quantum information processing.Comment: 7 pages, 4 figures, to appear in Nature Communication
Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice
<p>Background: Dietary restriction (DR) extends lifespan and induces beneficial metabolic effects in many animals. What is far less clear is whether animals retain a metabolic memory to previous DR exposure, that is, can early-life DR preserve beneficial metabolic effects later in life even after the resumption of ad libitum (AL) feeding. We examined a range of metabolic parameters (body mass, body composition (lean and fat mass), glucose tolerance, fed blood glucose, fasting plasma insulin and insulin-like growth factor 1 (IGF-1), insulin sensitivity) in male C57BL/6 mice dietary switched from DR to AL (DR-AL) at 11âmonths of age (mid life). The converse switch (AL-DR) was also undertaken at this time. We then compared metabolic parameters of the switched mice to one another and to age-matched mice maintained exclusively on an AL or DR diet from early life (3âmonths of age) at 1âmonth, 6âmonths or 10âmonths post switch.</p>
<p>Results: Male mice dietary switched from AL-DR in mid life adopted the metabolic phenotype of mice exposed to DR from early life, so by the 10-month timepoint the AL-DR mice overlapped significantly with the DR mice in terms of their metabolic phenotype. Those animals switched from DR-AL in mid life showed clear evidence of a glycemic memory, with significantly improved glucose tolerance relative to mice maintained exclusively on AL feeding from early life. This difference in glucose tolerance was still apparent 10âmonths after the dietary switch, despite body mass, fasting insulin levels and insulin sensitivity all being similar to AL mice at this time.</p>
<p>Conclusions: Male C57BL/6 mice retain a long-term glycemic memory of early-life DR, in that glucose tolerance is enhanced in mice switched from DR-AL in mid life, relative to AL mice, even 10âmonths following the dietary switch. These data therefore indicate that the phenotypic benefits of DR are not completely dissipated following a return to AL feeding. The challenge now is to understand the molecular mechanisms underlying these effects, the time course of these effects and whether similar interventions can confer comparable benefits in humans.</p>
Preferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAs
In this study, we comprehensively explored the stably expressed genes (SE genes) and fluctuant genes (FL genes) in the human genome by a meta-analysis of large scale microarray data. We found that these genes have distinct function distributions. miRNA targets are shown to be significantly enriched in SE genes by using propensity analysis of miRNA regulation, supporting the hypothesis that miRNAs can buffer whole genome expression fluctuation. The expression-buffering effect of miRNA is independent of the target site number within the 3'-untranslated region. In addition, we found that gene expression fluctuation is positively correlated with the number of transcription factor binding sites in the promoter region, which suggests that coordination between transcription factors and miRNAs leads to balanced responses to external perturbations
Backbone and side-chain 1H, 13C and 15N assignments of the ubiquitin-associated domain of human X-linked inhibitor of apoptosis protein
X-linked inhibitor of apoptosis protein (XIAP), a leading member of the family of inhibitor of apoptosis (IAP) proteins, is considered as the most potent and versatile inhibitor of caspases and apoptosis. It has been reported that XIAP is frequently overexpressed in cancer and its expression level is implicated in contributing to tumorigenesis, disease progression, chemoresistance and poor patient-survival. Therefore, XIAP is one of the leading targets in drug development for cancer therapy. Recently, based on bioinformatics study, a previously unrecognized but evolutionarily conserved ubiquitin-associated (UBA) domain in IAPs was identified. The UBA domain is found to be essential for the oncogenic potential of IAP, to maintain endothelial cell survival and to protect cells from TNF-α-induced apoptosis. Moreover, the UBA domain is required for XIAP to activate NF-ÎșB. In the present study, we report the near complete resonance assignments of the UBA domain-containing region of human XIAP protein. Secondary structure prediction based on chemical shift index (CSI) analysis reveals that the protein is predominately α-helical, which is consistent with the structures of known UBA proteins
Observation of eight-photon entanglement
Using ultra-bright sources of pure-state entangled photons from parametric
down conversion, an eight-photon interferometer and post-selection detection,
we demonstrate the ability to experimentally manipulate eight individual
photons and report the creation of an eight-photon Schr\"odinger cat state with
an observed fidelity of .Comment: 6 pages, 4 figure
Frozen and Invariant Quantum Discord under Local Dephasing Noise
In this chapter, we intend to explore and review some remarkable dynamical
properties of quantum discord under various different open quantum system
models. Specifically, our discussion will include several concepts connected to
the phenomena of time invariant and frozen quantum discord. Furthermore, we
will elaborate on the relation of these two phenomena to the non-Markovian
features of the open system dynamics and to the usage of dynamical decoupling
protocols.Comment: 29 pages, 8 figure
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