Decays, contact P-wave interactions and hyperfine structure in Omega- exotic atoms

Contact $P$-wave interactions connected to the Larmor interaction of a magnetic dipole and Thomas spin precession in the filed of an electric quadrupole are described and their implications for spectroscopy of exotic $\Omega^{-}$-atoms are studied. In order to evaluate the magnitude of the contact $P$-wave interactions as compared to the conventional long-range interactions and the sensitivity of spectroscopic data to the $\Omega^{-}$-hyperon quadrupole moment, we consider $2P$ states of $\Omega ^{-}$ atoms formed with light stable nuclei with spins $I \geq 1/2$ and atomic numbers $Z \leq 10$. The energy level splitting caused by the contact interactions is 2-5 orders of magnitude smaller than the conventional long-range interactions. Strong decay widths of $p\Omega ^{-}$ atoms due to reactions $p\Omega^{-} \to \Lambda \Xi^{0}$ and $p\Omega^{-} \to \Sigma \Xi$, induced by $t$-channel kaon exchanges, are calculated. $\Omega ^{-}$ atoms formed with the light nuclei have strong widths 5-6 orders of magnitude higher than splitting caused by the contact interactions. The low-$L$ pattern in the energy spectra of intermediate- and high-$Z$ $\Omega ^{-}$ atoms thus cannot be observed. The $\Omega ^{-}$ quadrupole moment can be measured by observing $X$-rays from circular transitions between high-$L$ levels in $\Omega^{-}$ exotic atoms. The effect of strong interactions in $^{208}$Pb$\Omega ^{-}$ atoms is negligible starting from $L \sim 10$. The contact $P$-wave interactions exist in ordinary atoms and $\mu$-meson atoms.Comment: LaTeX 49 pages, 3 eps figures, replaced with published versio

The antinucleon-nucleon interaction at low energy : annihilation dynamics

The general properties of antiproton-proton annihilation at rest are presented, with special focus on the two-meson final states. The data exhibit remarkable dynamical selection rules : some allowed annihilation modes are suppressed by one order of magnitude with respect to modes of comparable phase-space. Various phenomenological analyses are reviewed, based on microscopic quark dynamics or symmetry considerations. The role of initial- and final-state interaction is also examined.Comment: 128 pages, 49 tables, 27 figure

High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study

One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treatment separations, or for the development of diagnostic algorithms or relevant outcome measures. We aimed to establish agreement on high-resolution CT (HRCT) phenotypic separations in sarcoidosis to anchor future CT research through a multinational two-round Delphi consensus process. Delphi participants included members of the Fleischner Society and the World Association of Sarcoidosis and other Granulomatous Disorders, as well as members' nominees. 146 individuals (98 chest physicians, 48 thoracic radiologists) from 28 countries took part, 144 of whom completed both Delphi rounds. After rating of 35 Delphi statements on a five-point Likert scale, consensus was achieved for 22 (63%) statements. There was 97% agreement on the existence of distinct HRCT phenotypes, with seven HRCT phenotypes that were categorised by participants as non-fibrotic or likely to be fibrotic. The international consensus reached in this Delphi exercise justifies the formulation of a CT classification as a basis for the possible definition of separate diseases. Further refinement of phenotypes with rapidly achievable CT studies is now needed to underpin the development of a formal classification of sarcoidosis

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Recursively constructed graph families : membership and linear algorithms

Ph.D.Gary Parke

Algorithms and Complexity Results for Pursuit-Evasion Problems

We study pursuit-evasion problems where a number of pursuers have to clear a given graph. We study when polynomial-time algorithms exist to determine how many pursuers are needed to clear a given graph and how a given number of pursuers should move on the graph to clear it with either a minimum sum of their travel distances or minimum task-completion time. We generalize prior work to both unit-width arbitrary-length and unitlength arbitrary-width graphs and derive both algorithms and complexity results for a variety of graph topologies. In this context, we describe a polynomial-time algorithm, called CLEARTHETREE, that is much shorter and algorithmically simpler than the state-of-the-art algorithm for the minimum pursuer problem on trees. Our theoretical research lays a firm theoretical foundation for pursuit evasion on graphs and informs practitioners about which problems are easy and which ones are hard

Solving Problems on Recursively Constructed Graphs

Fast algorithms can be created for many graph problems when instances are confined to classes of graphs that are recursively constructed. This paper first describes some basic conceptual notions regarding the design of such fast algorithms, and then the coverage proceeds through several recursive graph classes. Specific classes include k-terminal graphs, trees, series-parallel graphs, k-trees, partial k-trees, Halin graphs, bandwidth-k graphs, pathwidth-k graphs, treewidthk graphs, branchwidth-k graphs, cographs, cliquewidth-k graphs, k-NLC graphs, k-HB graphs, and rankwidth-k graphs. The definition of each class is provided, after which some typical algorithms are applied to solve problems on instances of each class