The tragic satire of John Webster.

Bibliographical references included in "Notes" (p. 151-158

Plays

1007 p. ; 21 cm

Plays

1104 p. ; 21 cm

Plays

1092 p. ; 21 cm

Eugene O\u27Neill Conference 1984: Session H, Work Diaries and Letters, recording

In this conference session recording, papers are presented by three speakers: Virginia Floyd, Travis Bogard, and Jackson Bryer. Steven Bloom moderates the session, which includes a question and answer period at the end.https://dc.suffolk.edu/wilkins/1034/thumbnail.jp

Eugene O\u27Neill Conference 1986: Session C, Biographical Illumination, recording

In this conference session recording, papers are presented by three speakers: Travis Bogard, Stephen A. Black, and Virginia Floyd. The session concludes with a question and answer period.https://dc.suffolk.edu/wilkins/1044/thumbnail.jp

Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence

SummaryThe function of the Vibrio 7th pandemic island-1 (VSP-1) in cholera pathogenesis has remained obscure. Utilizing chromatin immunoprecipitation sequencing and RNA sequencing to map the regulon of the master virulence regulator ToxT, we identify a TCP island-encoded small RNA that reduces the expression of a previously unrecognized VSP-1-encoded transcription factor termed VspR. VspR modulates the expression of several VSP-1 genes including one that encodes a novel class of di-nucleotide cyclase (DncV), which preferentially synthesizes a previously undescribed hybrid cyclic AMP-GMP molecule. We show that DncV is required for efficient intestinal colonization and downregulates V. cholerae chemotaxis, a phenotype previously associated with hyperinfectivity. This pathway couples the actions of previously disparate genomic islands, defines VSP-1 as a pathogenicity island in V. cholerae, and implicates its occurrence in 7th pandemic strains as a benefit for host adaptation through the production of a regulatory cyclic di-nucleotide