Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis.

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The prevalence of potentially inappropriate prescribing among Hong Kong older adults: a comparison among Beers 2003, Beers 2012, and STOPP/START criteria

INTRODUCTION/OBJECTIVES: Inappropriate prescribing can lead to adverse drug events and older adults are at greater risk due to multiple chronic co-morbidities and multiple medications prescribed. Various criteria (eg Beers or STOPP [Screening Tool of Older Person’s Prescriptions]) on medication usage have been developed to assess prescribing appropriateness. The objectives of this study were (1) to determine the prevalence of potentially inappropriate prescribings (PIPs) among Hong Kong older adults using 2003 Beers, 2012 Beers, and STOPP criteria, and (2) to evaluate the association between …published_or_final_versio

Utilization of glucose, blood pressure, and lipid lowering medications among people with type II diabetes in the United States, 1999-2010

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The Cytokine response of rat macrophages to lipopolysaccharide is modulated by adrenomedullin

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Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA

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Association between SGLT2 Inhibitors vs DPP-4 Inhibitors and Risk of Pneumonia Among Patients with Type 2 Diabetes

Context: Patients with diabetes are at a higher risk of pneumonia and pneumonia mortality. Sodium glucose co-transporter 2 inhibitors (SGLT2is), the latest class of glucose-lowering agents, were shown to reduce the risk of pneumonia in clinical trials. However, the real-world effectiveness of SGLT2is on the risk of pneumonia is largely unknown. Objective: To investigate the associations between SGLT2is use and the risk of pneumonia and pneumonia mortality compared with dipeptidyl peptidase-4 inhibitors (DPP4is) using an electronic medical database in Hong Kong. Design A retrospective cohort study. The “prevalent new-user” design was adopted to account for the previous exposure to the study drugs being compared. Propensity score (PS) matching (1:4) was used to balance the baseline characteristics of the 2 groups. Setting and participants Electronic health data of type 2 diabetes patients using SGLT2is and DPP4is between 2015 and 2018 was collected from the Clinical Data Analysis and Reporting System. Main Outcome Measures: Pneumonia incidence and mortality. Results: The PS-matched cohort consisted of 6664 users of SGLT2is and 26 656 users of DPP4is, with a mean follow-up of 3.8 years. Poisson regression showed that SGLT2is use was associated with lower risk of pneumonia compared with DPP4is with an absolute rate difference of 4.05 per 1000 person-years (95% CI, 2.61-5.51). The corresponding incidence rate ratio was 0.71 (95% CI, 0.62-0.81). Similar reduction in risk of pneumonia death was observed (hazard ratio 0.57; 95% CI, 0.42-0.77). Conclusion: Compared with DPP4is, SGLT2is use was associated with a reduced risk of pneumonia and pneumonia mortality in a real-world setting

Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide

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Vitamin K intake reduces mortality in people with chronic kidney disease

Vitamin K intake reduces mortality in people with chronic kidney diseasepublished_or_final_versio

An evaluation of the association between inappropriate prescribing and drug related hospital admission

Electronic Presentations - no. 1156INTRODUCTION: Adverse drug event with inappropriate prescribing is one reason for hospital admissions. Older people are vulnerable to adverse drug events because of polypharmacy. However, association between potentially inappropriate prescribing (PIP) and drug related hospital admission is lacking …published_or_final_versio