Regional and local labour market prospects : the importance of ageing in workforce development

Overall, the labour force in the UK is ageing, although at different rates in different areas. This poses challenges for workforce development, and has implications not only for older workers, but for everyone, everywhere. However, demography is only one element in labour supply. It needs to be considered alongside trends in participation rates and in a broader policy and cultural context, and alongside likely changes in labour demand, in order to gain a picture of regional and local labour market prospects. The thrust of government policy is to raise employment rates amongst older people (aged 50-69) and to promote 'active ageing'. The decline in employment rates amongst older men evident in the 1980s has been reversed, but participation rates remain low by earlier standards. Shifts in the industrial and occupational structure of employment mean that there is likely to be a growing demand for customer care and service skills, which older people are well-placed to provide. Yet estimates of 'replacement demand' show that some of the most pressing workforce development issues are experienced in declining sectors and occupations, with an older than average age profile. Examples include agriculture and social care in Cornwall, where there is a lack of new recruits to replace those retiring. It is concluded that improved local intelligence on labour market flows and prospects is needed to inform skills and learning priorities. Copyright (c) 2006 John Wiley & Sons, Ltd

Development of Budesonide Microparticles Using Spray-Drying Technology for Pulmonary Administration: Design, Characterization, In Vitro Evaluation, and In Vivo Efficacy Study

The purpose of this research was to generate, characterize, and investigate the in vivo efficacy of budesonide (BUD) microparticles prepared by spray-drying technology with a potential application as carriers for pulmonary administration with sustained-release profile and improved respirable fraction. Microspheres and porous particles of chitosan (drug/chitosan, 1:2) were prepared by spray drying using optimized process parameters and were characterized for different physicochemical parameters. Mass median aerodynamic diameter and geometric standard deviation for conventional, microspheres, and porous particles formulations were 2.75, 4.60, and 4.30 µm and 2.56, 1.75, and 2.54, respectively. Pharmacokinetic study was performed in rats by intratracheal administration of either placebo or developed dry powder inhalation (DPI) formulation. Pharmacokinetic parameters were calculated (Ka, Ke, Tmax, Cmax, AUC, and Vd) and these results indicated that developed formulations extended half life compared to conventional formulation with onefold to fourfold improved local and systemic bioavailability. Estimates of relative bioavailability suggested that developed formulations have excellent lung deposition characteristics with extended T1/2 from 9.4 to 14 h compared to conventional formulation. Anti-inflammatory activity of BUD and developed formulations was compared and found to be similar. Cytotoxicity was determined in A549 alveolar epithelial cell line and found to be not toxic. In vivo pulmonary deposition of developed conventional formulation was studied using gamma scintigraphy and results indicated potential in vitro–in vivo correlation in performance of conventional BUD DPI formulation. From the DPI formulation prepared with porous particles, the concentration of BUD increased fourfold in the lungs, indicating pulmonary targeting potential of developed formulations