77 research outputs found
Hepatitis B infection and the prevention of primary hepatocellular carcinoma : studies in Senegal
Multi-Gap Superconductivity in MgB2: Magneto-Raman Spectroscopy
Electronic Raman scattering studies on MgB2 single crystals as a function of
excitation and polarization have revealed three distinct superconducting
features: a clean gap below 37 cm-1 and two coherence peaks at 109 cm-1 and 78
cm-1 which we identify as the superconducting gaps in \pi- and \sigma-bands and
as the Leggett's collective mode arising from the fluctuation in the relative
phase between two superconducting condensates residing on corresponding bands.
The temperature and field dependencies of the superconducting features have
been established. A phononic Raman scattering study of the E2g boron stretching
mode anharmonicity and of superconductivity induced self-energy effects is
presented. We show that anharmonic two phonon decay is mainly responsible for
the unusually large linewidth of the E2g mode. We observe ~2.5% hardening of
the E2g phonon frequency upon cooling into the superconducting state and
estimate the electron-phonon coupling strength associated with this
renormalization.Comment: Invited review in a special issue "Superconductivity in MgB_2:
Physics and Applications
Two-magnon Raman scattering in insulating cuprates: Modifications of the effective Raman operator
Calculations of Raman scattering intensities in spin 1/2 square-lattice
Heisenberg model, using the Fleury-Loudon-Elliott theory, have so far been
unable to describe the broad line shape and asymmetry of the two magnon peak
found experimentally in the cuprate materials. Even more notably, the
polarization selection rules are violated with respect to the
Fleury-Loudon-Elliott theory. There is comparable scattering in and
geometries, whereas the theory would predict scattering in only
geometry. We review various suggestions for this discrepency and
suggest that at least part of the problem can be addressed by modifying the
effective Raman Hamiltonian, allowing for two-magnon states with arbitrary
total momentum. Such an approach based on the Sawatzsky-Lorenzana theory of
optical absorption assumes an important role of phonons as momentum sinks. It
leaves the low energy physics of the Heisenberg model unchanged but
substantially alters the Raman line-shape and selection rules, bringing the
results closer to experiments.Comment: 7 pages, 6 figures, revtex. Contains some minor revisions from
previous versio
Rapid clearance profile of plasma circulating tumor HPV type 16 DNA during chemoradiotherapy correlates with disease control in HPV-associated oropharyngeal cancer
Purpose: To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Experimental Design: A multi-institutional prospective biomarker trial was conducted in 103 patients with (i) p16- positive OPSCC, (ii) M0 disease, and (iii) receipt of definitive CRT. Blood specimens were collected at baseline, weekly during CRT, and at follow-up visits. Optimized multianalyte digital PCR assays were used to quantify ctHPVDNA (types 16/18/31/33/35) in plasma. A control cohort of 55 healthy volunteers and 60 patients with non-HPV-associated malignancy was also analyzed. Results: Baseline plasma ctHPVDNA had high specificity (97%) and high sensitivity (89%) for detecting newly diagnosed HPV-associated OPSCC. Pretreatment ctHPV16DNA copy number correlated with disease burden, tumor HPV copy number, and HPV integration status. We define a ctHPV16DNA favorable clearance profile as having high baseline copy number (>200 copies/mL) and >95% clearance of ctHPV16DNA by day 28 of CRT. Nineteen of 67 evaluable patients had a ctHPV16DNA favorable clearance profile, and none had persistent or recurrent regional disease after CRT. In contrast, patients with adverse clinical risk factors (T4 or >10 pack years) and an unfavorable ctHPV16DNA clearance profile had a 35% actuarial rate of persistent or recurrent regional disease after CRT (P = 0.0049). Conclusions: A rapid clearance profile of ctHPVDNA may predict likelihood of disease control in patients with HPVassociated OPSCC patients treated with definitive CRT and may be useful in selecting patients for deintensified therapy
Optical symmetries and anisotropic transport in high-Tc superconductors
A simple symmetry analysis of in-plane and out-of-plane transport in a family
of high temperature superconductors is presented. It is shown that generalized
scaling relations exist between the low frequency electronic Raman response and
the low frequency in-plane and out-of-plane conductivities in both the normal
and superconducting states of the cuprates. Specifically, for both the normal
and superconducting state, the temperature dependence of the low frequency
Raman slope scales with the axis conductivity, while the
Raman slope scales with the in-plane conductivity. Comparison with experiments
in the normal state of Bi-2212 and Y-123 imply that the nodal transport is
largely doping independent and metallic, while transport near the BZ axes is
governed by a quantum critical point near doping holes per
CuO plaquette. Important differences for La-214 are discussed. It is also
shown that the axis conductivity rise for is a consequence of
partial conservation of in-plane momentum for out-of-plane transport.Comment: 16 pages, 8 Figures (3 pages added, new discussion on pseudogap and
charge ordering in La214
PIK3CA mutation in HPV-associated OPSCC patients receiving deintensified chemoradiation
PIK3CA is the most frequently mutated gene in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Prognostic implications of such mutations remain unknown. We sought to elucidate the clinical significance of PIK3CA mutations in HPV-associated OPSCC patients treated with definitive chemoradiation (CRT). Seventyseven patients with HPV-associated OPSCC were enrolled on two phase II clinical trials of deintensified CRT (60 Gy intensitymodulated radiotherapy with concurrent weekly cisplatin). Targeted next-generation sequencing was performed. Of the 77 patients, nine had disease recurrence (two regional, four distant, three regional and distant). Thirty-four patients had mutation( s) identified; 16 had PIK3CA mutations. Patients with wild-type-PIK3CA had statistically significantly higher 3-year disease-free survival than PIK3CA-mutant patients (93.4%, 95% confidence interval [CI] = 85.0% to 99.9% vs 68.8%, 95% CI = 26.7% to 89.8%; P=.004). On multivariate analysis, PIK3CA mutation was the only variable statistically significantly associated with disease recurrence (hazard ratio = 5.71, 95% CI = 1.53 to 21.3; P=.01). PIK3CA mutation is associated with worse diseasefree survival in a prospective cohort of newly diagnosed HPV-associated OPSCC patients treated with deintensified CRT
On the relative positions of the peaks in Raman and tunneling spectra of d-wave superconductors
We study Raman intensity and the density of states
in isotropic 2D d-wave superconductors. For an ideal gas,
and have sharp peaks at and , respectively, where is the maximum value of the gap.
We study how the peak positions are affected by the fermionic damping due to
impurity scattering.
We show that while the damping generally shifts the peak positions to larger
frequencies, the peak in still occurs at almost twice the peak
position in and therefore cannot account for the experimentally
observed downturn shift of the peak frequency in in underdoped
cuprates compared to twice that in . We also discuss how the
fermionic damping affects the dynamical spin susceptibility.Comment: 5 pages, 2 figure
Hepatites pĂłs-transfusionais na cidade de Campinas, SP, Brasil: I. IncidĂȘncia, agentes etiolĂłgicos e aspectos clĂnico-epidemiolĂłgicos da hepatite por vĂrus C
The Australia antigen in Brazilian healthy persons and in leprosy and leukaemia patients
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