72 research outputs found
Chemical potential oscillations from a single nodal pocket in the underdoped high-Tc superconductor YBa2Cu3O6+x
The mystery of the normal state in the underdoped cuprates has deepened with
the use of newer and complementary experimental probes. While photoemission
studies have revealed solely `Fermi arcs' centered on nodal points in the
Brillouin zone at which holes aggregate upon doping, more recent quantum
oscillation experiments have been interpreted in terms of an ambipolar Fermi
surface, that includes sections containing electron carriers located at the
antinodal region. To address the question of whether an ambipolar Fermi surface
truly exists, here we utilize measurements of the second harmonic quantum
oscillations, which reveal that the amplitude of these oscillations arises
mainly from oscillations in the chemical potential, providing crucial
information on the nature of the Fermi surface in underdoped YBa2Cu3O6+x. In
particular, the detailed relationship between the second harmonic amplitude and
the fundamental amplitude of the quantum oscillations leads us to the
conclusion that there exists only a single underlying quasi-two dimensional
Fermi surface pocket giving rise to the multiple frequency components observed
via the effects of warping, bilayer splitting and magnetic breakdown. A range
of studies suggest that the pocket is most likely associated with states near
the nodal region of the Brillouin zone of underdoped YBa2Cu3O6+x at high
magnetic fields.Comment: 7 pages, 4 figure
Magnetic-field-induced charge-stripe order in the high temperature superconductor YBa2Cu3Oy
Electronic charges introduced in copper-oxide planes generate high-transition
temperature superconductivity but, under special circumstances, they can also
order into filaments called stripes. Whether an underlying tendency of charges
to order is present in all cuprates and whether this has any relationship with
superconductivity are, however, two highly controversial issues. In order to
uncover underlying electronic orders, magnetic fields strong enough to
destabilise superconductivity can be used. Such experiments, including quantum
oscillations in YBa2Cu3Oy (a notoriously clean cuprate where charge order is
not observed) have suggested that superconductivity competes with spin, rather
than charge, order. Here, using nuclear magnetic resonance, we demonstrate that
high magnetic fields actually induce charge order, without spin order, in the
CuO2 planes of YBa2Cu3Oy. The observed static, unidirectional, modulation of
the charge density breaks translational symmetry, thus explaining quantum
oscillation results, and we argue that it is most likely the same 4a-periodic
modulation as in stripe-ordered cuprates. The discovery that it develops only
when superconductivity fades away and near the same 1/8th hole doping as in
La2-xBaxCuO4 suggests that charge order, although visibly pinned by CuO chains
in YBa2Cu3Oy, is an intrinsic propensity of the superconducting planes of high
Tc cuprates.Comment: For a final version, see
http://www.nature.com/nature/journal/v477/n7363/full/nature10345.htm
Symptomatic reactions, clinical outcomes and patient satisfaction associated with upper cervical chiropractic care: A prospective, multicenter, cohort study
<p>Abstract</p> <p>Background</p> <p>Observational studies have previously shown that adverse events following manipulation to the neck and/or back are relatively common, although these reactions tend to be mild in intensity and self-limiting. However, no prospective study has examined the incidence of adverse reactions following spinal adjustments using upper cervical techniques, and the impact of this care on clinical outcomes.</p> <p>Methods</p> <p>Consecutive new patients from the offices of 83 chiropractors were recruited for this practice-based study. Clinical outcome measures included 1) Neck pain disability index (100-point scale), 2) Oswestry back pain index (100-point scale), 3) 11-point numerical rating scale (NRS) for neck, headache, midback, and low back pain, 4) treatment satisfaction, and 5) Symptomatic Reactions (SR). Data were collected at baseline, and after approximately 2 weeks of care. A patient reaching sub-clinical status for pain and disability was defined as a follow-up score <3 NRS and <10%, respectively. A SR is defined as a new complaint not present at baseline or a worsening of the presenting complaint by >30% based on an 11-point numeric rating scale occurring <24 hours after any upper cervical procedure.</p> <p>Results</p> <p>A total of 1,090 patients completed the study having 4,920 (4.5 per patient) office visits requiring 2,653 (2.4 per patient) upper cervical adjustments over 17 days. Three hundred thirty- eight (31.0%) patients had SRs meeting the accepted definition. Intense SR (NRS ≥8) occurred in 56 patients (5.1%). Outcome assessments were significantly improved for neck pain and disability, headache, mid-back pain, as well as lower back pain and disability (<it>p </it><0.001) following care with a high level (mean = 9.1/10) of patient satisfaction. The 83 chiropractors administered >5 million career upper cervical adjustments without a reported incidence of serious adverse event.</p> <p>Conclusions</p> <p>Upper cervical chiropractic care may have a fairly common occurrence of mild intensity SRs short in duration (<24 hours), and rarely severe in intensity; however, outcome assessments were significantly improved with less than 3 weeks of care with a high level of patient satisfaction. Although our findings need to be confirmed in subsequent randomized studies for definitive risk-benefit assessment, the preliminary data shows that the benefits of upper cervical chiropractic care may outweigh the potential risks.</p
Assessment of musculoskeletal symptoms and their impacts in the adolescent population: adaptation and validation of a questionnaire
Muscle activation during gait in children with Duchenne muscular dystrophy
The aim of this prospective study was to investigate changes in muscle activity during gait in children with Duchenne muscular Dystrophy (DMD). Dynamic surface electromyography recordings (EMGs) of 16 children with DMD and pathological gait were compared with those of 15 control children. The activity of the rectus femoris (RF), vastus lateralis (VL), medial hamstrings (HS), tibialis anterior (TA) and gastrocnemius soleus (GAS) muscles was recorded and analysed quantitatively and qualitatively. The overall muscle activity in the children with DMD was significantly different from that of the control group. Percentage activation amplitudes of RF, HS and TA were greater throughout the gait cycle in the children with DMD and the timing of GAS activity differed from the control children. Significantly greater muscle coactivation was found in the children with DMD. There were no significant differences between sides. Since the motor command is normal in DMD, the hyper-activity and co-contractions likely compensate for gait instability and muscle weakness, however may have negative consequences on the muscles and may increase the energy cost of gait. Simple rehabilitative strategies such as targeted physical therapies may improve stability and thus the pattern of muscle activity
Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth
Though recent advancement in proteomics has provided a novel perspective on several distinct pathogenetic mechanisms leading to preterm birth (inflammation, bleeding), the etiology of most preterm births still remains elusive. We conducted a multidimensional proteomic analysis of the amniotic fluid to identify pathways related to preterm birth in the absence of inflammation or bleeding.A proteomic fingerprint was generated from fresh amniotic fluid using surface-enhanced laser desorbtion ionization time of flight (SELDI-TOF) mass spectrometry in a total of 286 consecutive samples retrieved from women who presented with signs or symptoms of preterm labor or preterm premature rupture of the membranes. Inflammation and/or bleeding proteomic patterns were detected in 32% (92/286) of the SELDI tracings. In the remaining tracings, a hierarchical algorithm was applied based on descriptors quantifying similarity/dissimilarity among proteomic fingerprints. This allowed identification of a novel profile (Q-profile) based on the presence of 5 SELDI peaks in the 10-12.5 kDa mass area. Women displaying the Q-profile (mean+/-SD, gestational age: 25+/-4 weeks, n = 40) were more likely to deliver preterm despite expectant management in the context of intact membranes and normal amniotic fluid clinical results. Utilizing identification-centered proteomics techniques (fluorescence two-dimensional differential gel electrophoresis, robotic tryptic digestion and mass spectrometry) coupled with Protein ANalysis THrough Evolutionary Relationships (PANTHER) ontological classifications, we determined that in amniotic fluids with Q-profile the differentially expressed proteins are primarily involved in non-inflammatory biological processes such as protein metabolism, signal transduction and transport.Proteomic profiling of amniotic fluid coupled with non-hierarchical bioinformatics algorithms identified a subgroup of patients at risk for preterm birth in the absence of intra-amniotic inflammation or bleeding, suggesting a novel pathogenetic pathway leading to preterm birth. The altered proteins may offer opportunities for therapeutical intervention and future drug development to prevent prematurity
The biopsychosocial model and chiropractic: a commentary with recommendations for the chiropractic profession
There is an increasing awareness, interest and acceptance of the biopsychosocial (BPS) model by all health care professionals involved with patient care. The areas of spine care and pain medicine are no exception, and in fact, these areas of health care are a major centerpiece of the movement from the traditional biomedical model to a BPS model of patient assessment and delivery of care. The chiropractic approach to health care has a history that is grounded in key aspects of the BPS model. The profession has inherently implemented certain features of the BPS model throughout its history, perhaps without a full understanding or realization. The purpose of this paper is to present an overview of the BPS model, its relationship with spine care and pain management, and to discuss the BPS model, particularly psychosocial aspects, in the context of its historical relationship with chiropractic. We will also provide recommendations for the chiropractic profession as it relates to successful adoption of a full integration of the BPS model
Sexual selection and mating system in Zorotypus gurneyi Choe (Insecta : Zoraptera)
Social behavior of a species in the little-known insect order Zoraptera is described for the first time. Zorotypus gurneyi Choe (Insecta: Zoraptera) is a wing-dimorphic species that lives colonially under the bark of rotting logs in central Panama. Males are larger than females in total body size and fight each other to gain access to females. Highly linear and stable dominance hierarchies exist among males. Higher-ranking males show such agonistic behavior as jerking, chasing, head-butting, hindleg-kicking, and grappling, whereas subordinates often try to avoid contacts. Higher-ranking males, the dominant males in particular, are well recognized by others and relatively free of injuries. Although the dominant males are often the largest, the correlation between body size and dominance rank is not always significant. The mating system of Z. gurneyi is an example of female defense polygyny in which the dominant males obtain the majority of matings (75% on average). Mating success among Z. gurneyi males is much more variable than that of some lekking species.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46900/1/265_2004_Article_BF00164179.pd
Sexual selection and mating system in Zorotypus gurneyi Choe (Insecta: Zoraptera)
Body size is clearly an important factor influencing the outcome of agonistic contests, but is often weakly correlated with dominance ranks in Zorotypus gurneyi Choe (Insecta: Zoraptera). The study of the development and dynamics of dominance relations using artificially constructed colonies show that age, or tenure within the colony, is the prime determinant of dominance among males. Dominance hierarchies become relatively stable within 2 or 3 days and males that emerge later normally begin at the bottom of the hierarchy regardless of size. Males interact much more frequently when they are simultaneously introduced to each other than when they are allowed to emerge at different times. In the latter case, males that emerge late appear to recognize relative dominance of older males and avoid direct contests. Considering the high correlation between dominance rank and mating success, there is a strong selective advantage to males that emerge earlier and such pressure of sexual selection may be responsible for the difference in life history strategies between Z. gurneyi and its sympatric congener, Z. barberi Gurney, in central Panama.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46901/1/265_2004_Article_BF00183473.pd
Clinical examination findings as prognostic factors in low back pain: a systematic review of the literature
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