Polymerization of aniline in layered HMMoO6HMMoO_6·H2OH_2O (M=Nb,Ta)

Layered Bronsted acids, $HMMoO_6$·$H_2O$ (M=Nb, Ta) possessing a rutile-related structure, readily intercalates aniline giving $(C_6H_5NH_3)_xH_{1−x}MMoO_6·H_2O (x˜0.35)$. Oxidation of the latter in air at 130°C polymerizes the interlayer aniline to give $(PANI)_xH_{1−x}MMoO_6$ nanocomposites (PANI=polyaniline). Characterization of the composites by various physical methods reveals that the polymerization is near-quantitative, occurring within the galleries of the inorganic host. EPR spectroscopy shows a single resonance at g=2.003 which is characteristic of PANI, indicating that the inorganic host does not participate in the oxidative polymerization of aniline

Soft chemical synthesis of new layered and three-dimensional oxide hydrates, hxVxW1-xO3×yH2O, related to WO3×2 H2O and WO3. times.1/3 H2O

Two new vanadium-tungsten oxide hydrates of the formulas, H0.125V0.125W0.875O3.1.5H2O (I) and Ho.33V0.33W0.67O3.1/3H2O (II), have been synthesized by acid-leaching of LiVWO6 with aqueous HNO3/HCl. While phase I obtained by treatment of LiVWO6 with dilute HNO3/HCl possesses an orthorhombic structure (a = 7.77(3), b = 13.87(6), c = 7.44(3) angstrom) related to WO3.2H2O, phase II, prepared by refluxing LiVWO6 with concentrated HNO3, is isostructural with WO3.1/3H2O. Dehydration of II around 330-degrees-C yields a hexagonal phase (III, a = 7.25(4), c = 7.74(3) angstrom) isotypic with hexagonal WO3. Both land III exhibit redox and acid-base intercalation reactivity characteristic of layered and tunnel structures

Towards rational synthesis of inorganic solids

There have been major advances in the past couple of years in the rational synthesis of inorganic solids: synthesis of mercury-based superconducting cuprates showing transition temperatures up to 150 K; ZrP2-xVxO7 solid solutions showing zero or negative thermal expansion; copper oxides possessing ladder structures such as La1-xSrxCuO2.5; synthesis of mesoporous oxide materials having adjustable pore size in the range 15-100 Angstrom; and synthesis of a molecular ferromagnet showing a critical temperature of 18.6 K. Despite great advances in probing the structures of solids and measurement of their physical properties, the design and synthesis of inorganic solids possessing desired structures and properties remain a challenge today. With the availability of a variety of mild chemistry-based approaches, kinetic control of synthetic pathways is becoming increasingly possible, which, it is hoped, will eventually make rational design of inorganic solids a reality

A new charge density wave oxide, LiVMoO5LiVMoO_5 and its tungsten analogue obtained by topotactic reduction of LiVMO6LiVMO_6 (M=Mo,W) brannerites

We report the synthesis of two new low-dimensional oxides, LiVMO(5) (M = Mo, W), which contain S = 1/2 transition-metal atoms, V-IV:3d(1) and Mo-V:4d(1)/W-V:5d(1), by topotactic reduction of the LiVMO(6) brannerites in hydrogen. LiVMO(5) crystallizes in orthorhombic structures related to the parent brannerite structure. The VMO(5) network of the new oxides is likely to correspond to one of the A(2)X(5) structures predicted by A. F. Wells (Philos. Trans. R. Soc. London A, 1984, 312, 589). LiVMoO5 is metallic showing a charge density wave (CDW) instability around 230 K; interestingly, LiVWO5 is a paramagnetic semiconductor down to 20 K

A novel one-pot metathesis route for the synthesis of double perovskites, Ba3MM′2O9(M=Mg,Ni,Zn;M′=Nb,Ta)Ba_3MM'2O_9 (M = Mg, Ni, Zn; M' = Nb, Ta) with 1 : 2 ordering of M and M' atoms

Solid state reaction of $Li_2CO_3$, $MC_2O_4.2H_2O(M = Mg, Ni,Zn)$, $M'_2O_5 (M' = Nb, Ta)$ and $BaCl_2$ in stoichiometric quantities at $900-1100^o C$ in air provides a convenient one-pot synthesis route for 1 : 2 B-site ordered double perovskite oxides, $Ba_3MM'_2O_9$, that find application in microwave telecommunications

Bis(thiosemicarbazone)copper(I) Complexes as Prospective Therapeutic Agents: Interaction with DNA/BSA Molecules, and In Vitro and In Vivo Anti-Proliferative Activities

A series of six new bis(thiosemicarbazone) copper(I) complexes of the type [Cu(L1-6)(2)Cl] (1-6) were synthesized and characterized. The complexes adopted trigonal planar 'Y' shaped geometry coordinating through two thione sulphur atoms of two ligand molecules and one chloride ion. All the complexes intercalatively bind with calf thymus DNA (CT-DNA) as evidenced by spectral and molecular docking studies. The absorption and emission spectral techniques confirmed the strong interaction of the complexes with BSA via static quenching mode. The complexes efficiently cleave pBR322 DNA via hydrolytic pathway, and significantly interact with epidermal growth factor receptor. All the complexes were assessed for their anti-proliferative activity, in which the complexes 2, 3 and 4 containing methyl, methoxy and hydroxyl groups, respectively, showed significant activity. The complexes induce apoptosis in EAC cells as evidenced by acridine orange (AO)/ethidium bromide (EB), Hoechst 33258 and propidium iodide (PI) staining methods, and cell cycle analysis. Cellular uptake studies revealed the ability of the complexes to go into the cytoplasm and accumulation in the cell nuclei. The complexes are involved in the generation of reactive oxygen species (ROS), mitochondrial mediated and caspase-dependent apoptosis. Further, using a female Swiss albino mice model, we found that the complexes 2 and 3 inhibited Ehrlich ascites carcinoma (EAC) tumour cell growth in vivo