FORMULATION DEVELOPMENT AND EVALUATION OF ORALLY DISINTEGRATING TABLET OF CHLORPHENERAMINE MALEATE BY SUBLIMATION TECHNIQUE

Objective: Chlorpheneramine maleate is a first-generation antihistamine drug used in the treatment of allergic conditions like rhinitis, urticaria, and cough cold, etc. In present work, the challenge has been made to develop an orally disintegrating tablet of chlorpheneramine maleate with an increase in bioavailability and patient compliance. Methods: The sublimation technique was used to prepare orally disintegrating tablets. Porous tablet prepared after sublimation of camphor at 60 °C in a hot air oven for 60 min. In the research work, 32full factorial design used to find out the effect of two variables like the amount of Crospovidone and Croscarmellose sodium. Results: All prepared formulations were analyzed for various parameters. DSC of pure drug and optimized formulation A (9) showed purity of sample and compatibility of all ingredients with each other. In FTIR study of pure drug and optimized formulation A (9) no major shifts were seen. An optimized formulation (A9) was found to have good hardness (3.2 kg/cm2), friability (<1%), disintegration time (26 s), % drug release (99.77 %) within 6 min. Conclusion: The result obtained showed that orally disintegrating tablet of chlorpheneramine maleate enhances dissolution rate, improves bioavailability which will improve patient compliance

Formulation and Evaluation of Transdermal patches of Ropinirole HCl

ABSTRACT The conventional multidose antiparkinsons therapy leads to re-emergence of Parkinson's symptoms, due to fluctuations in serum levels of drug. The rational strategy to overcome this drawback is to minimize the fluctuations by fabricating sustained release formulations. Ropinirole HCl is a drug used to treat Parkinson's disorder and it is suitable drug candidate for transdermal delivery due to its small molecular size, optimum log P and low oral bioavailability due to first pass metabolism. Hence the present study was aimed at development of transdermal patch of Ropinirole HCl to show its prolonged release. The combination of HPMC K15 and Eudragit RL100 was tried as a porous matrix to control the release of Ropinirole HCl up to 12 hrs. The transdermal patches were prepared by solvent casting method. All the patches were evaluated for the permeation along with physical studies including appearance, thickness, folding endurance, drug content, percentage of moisture content and percentage of moisture uptake. The results of physical parameters ensured integrity, stability and applicability of the patches. The results of permeation studies clearly indicated that the release pattern of Ropinirole HCl can be controlled by maintaining appropriate proportion of HPMC K15 and Eudragit RL 100 in the matrix. No erythma was found within 12 hr after application of optimized transdermal patch when compared with standard irritant. Thus this formulation was suitable for transdermal application

Proceedings of National Conference on Relevance of Engineering and Science for Environment and Society

This conference proceedings contains articles on the various research ideas of the academic community and practitioners presented at the National Conference on Relevance of Engineering and Science for Environment and Society (R{ES}2 2021). R{ES}2 2021 was organized by Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India on July 25th, 2021. Conference Title: National Conference on Relevance of Engineering and Science for Environment and SocietyConference Acronym: R{ES}2 2021Conference Date: 25 July 2021Conference Location: Online (Virtual Mode)Conference Organizers: Shri Pandurang Pratishthan’s, Karmayogi Engineering College, Shelve, Pandharpur, India