Alcohol-induced changes in conflict monitoring and error detection as predictors of alcohol use in late adolescence

Adolescence is a vulnerable period for the development of substance use and related problems. Understanding how exposure to drugs influences the adolescent brain could reveal mechanisms underlying risk for addiction later in life. In the current study, 87 adolescents (16-20-year olds; the local legal drinking age was16, allowing the inclusion of younger subjects than usually possible) underwent EEG measurements during a Go/No-Go task with and without alcohol cues; after placebo and a low dose of alcohol (0.45 g/kg). Conflict monitoring and error detection processes were investigated with the N2 and the error-related negativity (ERN) ERP components. Participants were followed-up after 6 months to assess changes in alcohol use. The NoGo-N2 was larger for alcohol cues and acute alcohol decreased the amplitude of the NoGo-N2 for alcohol cues. ERN amplitude was blunted for alcohol cues. Acute alcohol decreased the amplitude of the ERN, specifically for control cues. Furthermore, the differences in ERN for alcohol cues between the placebo and alcohol conditions predicted alcohol use 6 months later: subjects who showed stronger blunting of the ERN after acute alcohol were more likely to return to more moderate drinking patterns. These results suggest that cues signalling reward opportunities might activate a go-response mode and larger N2 (detection of increased conflict) for these cues might be necessary for inhibition. The ERN results suggest a deficiency in the monitoring system for alcohol cues. Finally, a lack of alcohol-induced deterioration of error monitoring for cues with high salience might be a vulnerability factor for alcohol abuse in adolescents

Taming the wild elephant:Mindfulness and its role in overcoming automatic mental processes

There is increasing evidence that automatic mental processes contribute to self-regulation failures such as eating high-fat foods despite being on a diet and getting trapped in old ways of thinking about problems that require a novel response. Mindfulness meditation, which was developed to overcome habitual patterns of the mind that contribute to human suffering, holds great promise as a strategy to improve self-regulation. This chapter examines the idea that mindfulness may facilitate self-regulation by influencing automatic processes and their relation with subsequent cognition and behavior. After beginning with a discussion of the functional value of automatic processes, the chapter continues with a review of how these processes contribute to self-regulation failure. Next, a theoretical discussion is presented concerning mindfulness and how it might moderate automatic processes. After presenting a review of research addressing this topic, the chapter concludes with suggestions for future work