The unfolded protein response in immunity and inflammation.

The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands associated with environmental forces. In this role, the UPR has increasingly been shown to have crucial functions in immunity and inflammation. In this Review, we discuss the importance of the UPR in the development, differentiation, function and survival of immune cells in meeting the needs of an immune response. In addition, we review current insights into how the UPR is involved in complex chronic inflammatory diseases and, through its role in immune regulation, antitumour responses.This work was supported by the Netherlands Organization for Scientific Research Rubicon grant 825.13.012 (J.G.); US National Institutes of Health (NIH) grants DK044319, DK051362, DK053056 and DK088199, and the Harvard Digestive Diseases Center (HDDC) grant DK034854 (R.S.B.); National Institutes of Health grants DK042394, DK088227, DK103183 and CA128814 (R.J.K.); and European Research Council (ERC) Starting Grant 260961, ERC Consolidator Grant 648889, and the Wellcome Trust Investigator award 106260/Z/14/Z (A.K.).This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nri.2016.6

Leadership Tendencies of Government Employees in Oman: A Study of Task and Relationship based on Age and Gender

Relationship, Task, Leadership orientation, Oman, Age, Gender,

Social Innovation in Public Organisations: The Perspectives of Managers

The world today is not only becoming increasingly competitive but this competition is also increasingly intense and, for organisations, innovation emerges as one solution to the problems they face. Thus, innovation has attracted increased interest as the means to acquire and develop skills to address and/or inspire organisations in a globally competitive and economically uncertain environment. Furthermore, in such a competitive world, not even the public sector escapes the need to evolve towards providing better services and satisfying its citizens. However, just what is the need to evaluate social innovation in public organisations? Is there the drive to compete and/or market share to conquer? Profits to achieve? The public sector has many points in common with the private sector with the goals in both sectors involving the raising of efficiency and quality levels and better satisfaction for customers. Thus, this research aims at studying social innovation in public organisations and understanding how social innovation can better the lives of citizens from the perspective of managers. As the data collection method, we applied a questionnaire based on the constructs and scales already validated by Vigoda-Gadot (Public Administration 86(2):307–329, 2008) before then analysing the results through recourse to PLS. The results identify how responsiveness and ethics and morals are important factors in the perceptions of innovation as perceived by citizens. In turn, the findings also demonstrate the importance of this capacity for innovation to the image of the public sector as well as the confidence and satisfaction of its citizens.info:eu-repo/semantics/publishedVersio