23 research outputs found
Dynamic cratering of graphite : experimental results and simulations
The cratering process in brittle materials under hypervelocity impact (HVI) is of major relevance for debris shielding in spacecraft or high-power laser applications. Amongst other materials, carbon is of particular interest since it is widely used as elementary component in composite materials. In this paper we study a porous polycrystalline graphite under HVI and laser impact, both leading to strong debris ejection and cratering. First, we report new experimental data for normal impacts at 4100 and 4200 m s-1 of a 500-ÎĽm-diameter steel sphere on a thick sample of graphite. In a second step, dynamic loadings have been performed with a high-power nanosecond laser facility. High-resolution X-ray tomographies and observations with a scanning electron microscope have been performed in order to visualize the crater shape and the subsurface cracks. These two post-mortem diagnostics also provide evidence that, in the case of HVI tests, the fragmented steel sphere was buried into the graphite target below the crater surface. The current study aims to propose an interpretation of the results, including projectile trapping. In spite of their efficiency to capture overall trends in crater size and shape, semi-empirical scaling laws do not usually predict these phenomena. Hence, to offer better insight into the processes leading to this observation, the need for a computational damage model is argued. After discussing energy partitioning in order to identify the dominant physical mechanisms occurring in our experiments, we propose a simple damage model for porous and brittle materials. Compaction and fracture phenomena are included in the model. A failure criterion relying on Weibull theory is used to relate material tensile strength to deformation rate and damage. These constitutive relations have been implemented in an Eulerian hydrocode in order to compute numerical simulations and confront them with experiments. In this paper, we propose a simple fitting procedure of the unknown Weibull parameters based on HVI results. Good agreement is found with experimental observations of crater shapes and dimensions, as well as debris velocity. The projectile inclusion below the crater is also reproduced by the model and a mechanism is proposed for the trapping process. At least two sets of Weibull parameters can be used to match the results. Finally, we show that laser experiment simulations may discriminate in favor of one set of parameters
H4 Histamine Receptors Mediate Cell Cycle Arrest in Growth Factor-Induced Murine and Human Hematopoietic Progenitor Cells
The most recently characterized H4 histamine receptor (H4R) is expressed preferentially in the bone marrow, raising the question of its role during hematopoiesis. Here we show that both murine and human progenitor cell populations express this receptor subtype on transcriptional and protein levels and respond to its agonists by reduced growth factor-induced cell cycle progression that leads to decreased myeloid, erythroid and lymphoid colony formation. H4R activation prevents the induction of cell cycle genes through a cAMP/PKA-dependent pathway that is not associated with apoptosis. It is mediated specifically through H4R signaling since gene silencing or treatment with selective antagonists restores normal cell cycle progression. The arrest of growth factor-induced G1/S transition protects murine and human progenitor cells from the toxicity of the cell cycle-dependent anticancer drug Ara-C in vitro and reduces aplasia in a murine model of chemotherapy. This first evidence for functional H4R expression in hematopoietic progenitors opens new therapeutic perspectives for alleviating hematotoxic side effects of antineoplastic drugs
Investigation of fused silica dynamic behaviour
The survivability of the fused silica shields to shrapnel impacts is
a key factor for the affordable operation of the intense laser
irradiation future facility Laser MĂ©ga Joule (CEA-CESTA). This
paper presents experimental data and computational modelling for LMJ
fused silica upon shock wave loading and unloading. Gas-gun flyer
plate impact and explosively driven tests have been conducted to
investigate the dynamic behaviour of this material. Hugoniot states
and the Hugoniot Elastic Limit of LMJ fused silica have been
obtained. These experimental data are useful for determining some
constitutive model constants of the “Crack-Model”, a continuum
tensile and compressive failure model with friction based on
Rubin M. B. and Attia A. V.'s work. This model has been improved by
taking into account nonlinear elasticity. The numerical results
obtained by performing computations of the previous tests and some
ballistic impact tests are discussed. Further developments to
simulate the permanent densification and the solid-to-solid phase
transformation of fused silica are required
Understanding interactions between cementitious materials and microorganisms: a key to sustainable and safe concrete structures in various contexts (vol 47, pg 1787, 2014)
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