A Psychometric Examination of the Coronavirus Anxiety Scale and the Fear of Coronavirus Disease 2019 Scale in the Italian Population

The coronavirus disease 2019 (COVID-19) outbreak has caused not only significant physical health problems but also mental health disorders. Anxiety and fear appear to be the main psychological symptoms associated with COVID-19. The aim of this study was to investigate whether anxiety and fear related to COVID-19 are influenced by sociodemographics and whether specific conditions, such as positivity for COVID-19 or death among relatives and friends, can further enhance these symptoms. In this cross-sectional study, 697 Italians responded to an online survey assessing sociodemographic information, the presence/absence of positive cases, or deaths due to COVID-19 among relatives or acquaintances. The Coronavirus Anxiety Scale (CAS) and Fear of COVID-19 Scale (FCS-19S) were administered in order to assess the levels of anxiety and fear associated with COVID-19. The data were collected in November 2020. Anxiety and fear scores were positively correlated. Both male and female subjects with higher CAS scores also displayed higher FCS-19S scores. The CAS and FCS-19S scores tended to increase with age, with older subjects exhibiting higher scores than younger subjects. Additionally, respondents with lower educational levels demonstrated higher scores on both the CAS and FCS-19S. Similarly, respondents living with older people and/or experiencing the death of one or more relatives due to COVID-19 exhibited corresponding outcomes. This study demonstrates how the levels of anxiety and fear, measured by CAS and FCS-19S associated with COVID-19, are influenced by gender, age, cohabitation status, educational levels, and the presence of positive cases or deaths due to COVID-19

Do Autistic Traits Correlate with Post-Traumatic Stress and Mood Spectrum Symptoms among Workers Complaining of Occupational Stress?

The adult autism subthreshold spectrum model appears to be a useful tool for detecting possible vulnerability factors in order to develop mental disorders in the contest of work-related stress. The aim of the present study is to analyze the relationship between autism, mood, and post-traumatic spectrum in a cohort of subjects complaining of work-related stress before the COVID-19 pandemic. The authors carried out a retrospective investigation of both medical records and self-assessment tools of a sample of subjects evaluated at the Occupational Health Department of a University hospital in central Italy. Data showed significant correlations between the AdAS spectrum, TALS-SR, and MOODS total and domain scores. A multiple linear regression evidenced that both the AdAS spectrum and TAL-SR significantly predict the MOODS scores. In particular, mediation analysis showed both a direct and indirect, mediated by TALS-SR, effect of the AdAS Spectrum on the MOODS-SR. These results corroborate the role of autistic traits in influencing the traumatic impact of work-related stress and the development of mood spectrum symptoms

Valutazione delle prestazioni nel sistema sanitario : Il caso di studio del Pronto Soccorso dell'Azienda USL Toscana Nord-Ovest Massa Carrara

Il seguente progetto di tesi raccoglie l’esperienza di tirocinio (Dicembre ’16 – Giugno ’17), presso l’azienda Sanitaria Usl Toscana Nord Ovest: Ambito territoriale Massa e Carrara. L’Obiettivo del tirocinio è stato quello di misurare le performance del reparto di Pronto Soccorso, individuare i flussi dei pazienti e analizzare le criticità riscontrate con l’ausilio di tecniche di Process Mining. La metodologia seguita ha previsto un'analisi delle prestazioni realizzata sia tramite interviste ed esperienza sul campo sia attraverso lo studio del database informativo di Pronto Soccorso mediante tecniche di Process Mining, che grazie all’individuazione dei vari flussi dei pazienti ha permesso di identificare i colli di bottiglia, le attese medie e le inefficienze. Tali informazioni sono state congiunte con indicatori suggeriti dalla letteratura per la misurazione delle performance in un Pronto Soccorso. Il progetto ha portato quindi a una precisa individuazione delle aree di criticità nelle quali intervenire, ha fornito possibili soluzioni a tali criticità, ha risolto, inoltre, criticità inerenti la scarsa disponibilità di dati e deviazioni di processo presenti fino ad oggi, infine ha agevolato l’introduzione di pannelli informativi del flusso del paziente in sala d’attesa, aumentando la qualità percepita del servizio

Il sonno locale come possibile causa di perdite temporanee dell'autocontrollo nella soppressione comportamentale delle emozioni: uno studio EEG ad alta densità

Among the main emotional regulation strategies there is expressive suppression, which consists in inhibiting behavioural responses elicited by stimuli with emotional value. Of note, expressive suppression represents a form of self-control, that is, the ability to voluntarily suppress different types of impulses. Some studies have shown that failures in self-control may be associated with temporary local increases in low-frequency (< 9 Hz) electroencephalographic (EEG) activity – also indicated as local sleep-like episodes - within frontal brain regions. Converging lines of evidence showed that the incidence of these episodes increases during prolonged wakefulness. Moreover, it is well known that sleep restriction or deprivation commonly determine significant alterations in emotional regulation. Based on these considerations, this Thesis project aimed at investigating whether local sleep-like episodes could represent a possible cause of failure in the implementation of expressive suppression strategies. Nineteen healthy volunteers (26.3 ± 2.9 years, 10F) completed two distinct experimental sessions during which amusing video clips were presented and brain activity was continuous recorded using EEG (64 electrodes). In one experimental session, participants were asked to inhibit the emotional behavioural response, with the instruction to maintain a neutral facial expression (expressive suppression, ES), while in the other experimental session they were allowed to freely express their emotions (free expression, FE). The changes in facial expression were monitored through video recordings. Finally, the sleep/wake patterns of the days preceding the experiments was monitored through wrist-worn actigraphy. The obtained results demonstrate that the failures of expressive suppression (i.e. changes of facial expression in the ES condition) are preceded by an increase in delta activity (1-4 Hz) in the frontal and parietal regions (p <0.05). Moreover, a shorter sleep duration on the night preceding the ES condition is associated with a greater number of failures (p = 0.01) and greater delta activity in frontal regions during the failure of expressive suppression (p = 0.03). These results demonstrate that local sleep-like episodes in brain regions associated with emotional regulation may represent a possible direct cause of failure in expressive suppression, and that their probability of occurrence is directly influenced by the hours slept during the previous night

Targeting temporal parietal junction for assessing and treating disembodiment phenomena: a systematic review of TMS effect on depersonalization and derealization disorders (DPD) and body illusions

The temporal-parietal junction (TPJ) is a key structure for the embodiment, term referred to as the sense of being localized within one's physical body and is a fundamental aspect of the self. On the contrary, the sense of disembodiment, an alteration of one's sense of self or the sense of being localized out of one's physical body, is a prominent feature in specific dissociative disorders, namely depersonalization/derealization disorders (DPD). The aims of the study were to provide: 1) a qualitative synthesis of the effect of Transcranial Magnetic Stimulation (TMS), taking into account its use for therapeutic and experimental purposes; 2) a better understanding on whether the use of TMS could support the treatment of DPD and other clinical conditions in which depersonalization and derealization are displayed. To identify suitable publications, an online search of the PubMed, Cochrane Library, Web of science and Scopus databases was performed using relevant search terms. In addition, an in-depth search was performed by screening review articles and the references section of each included articles. Our search yielded a total of 108 records through multiple databases searching and one additional record was identified through other sources. After duplicates removal, title and abstract reading, we retained 16 records for the assessment of eligibility. According to our inclusion criteria, we retained 8 studies. The selected studies showed that TMS targeting the TPJ is a promising technique for treating disembodiment phenomena DPD and for inducing reversible disembodiment states in healthy subjects. These data represent the first step towards a greater understanding of possible treatments to be used in disembodiment disorders. The use of TMS over the TPJ appears to be promising for treating disembodiment phenomena

Human biomonitoring to assess exposure to thallium following the contamination of drinking water.

In 2014, in some parts of the water distribution system of the municipality of Pietrasanta (Tuscany, Italy), thallium (Tl) levels above the recommended limits were measured and some restrictions to water usage for drinking and food preparation were imposed. The study aimed to assess Tl exposure and possible health effects by means of a human biomonitoring survey. In the 2014-2016 time frame, 2154 urine and 254 hair samples were taken from different population groups and from a control group. The levels of Tl found in urine and hair were statistically higher in exposed groups than in controls and compared to the reference values for the general population. Concentrations in urine were significantly associated with the geographical origin of the sample, the consumption of drinking water and food grown in local gardens. A significant association was found between urine and hair. No positive associations were found between the Tl levels in hair or urine and several self-reported symptoms and health effects, except for sleep disturbance. The study indicates that the concentration of Tl in drinking water can be traced by urine analysis. Urine and hair have proven to be biological matrices that can be effectively used for the evaluation of Tl exposure. To date, the study represents the most extensive human biomonitoring campaign for the evaluation of the Tl exposure available at international level

Thallium Contamination of Drinking Water: Health Implications in a Residential Cohort Study in Tuscany (Italy)

In 2014–2015, concentrations of thallium above the recommended reference value (EPA: 2 µg/L) were measured in some parts of the drinking water distribution system in the municipality of Pietrasanta (Tuscany, Italy). An extensive campaign of water samples and human biomonitoring surveys were implemented to quantify the exposure of population. A residential cohort epidemiological study was carried out on the population of the municipality of Pietrasanta, aimed at comparing the health status of residents in the areas affected by thallium contamination with residents living in the rest of the municipality. Cohort included people residing in the municipality of Pietrasanta from 1 January 2000 to 31 December 2015. Residence addresses were georeferenced and each subject living in one of the three contaminated areas were defined as exposed. Mortality, hospital discharge data and adverse pregnancy outcomes were taken from administrative health databases. Cox proportional hazard models and logistic models were used to test the association between thallium exposure and health outcome. This study did not show any excess of risk in terms of mortality and hospitalization in the population residing in the areas served by thallium-contaminated aqueduct branches, compared to the rest of the not contaminated area. Increased risks for low birth weight (OR = 1.43 95% CI 0.91–2.25) and pre-term birth (OR = 1.40 95% CI 0.82–2.37) were observed. In view of the paucity of epidemiological studies on thallium, this study is an important contribution to the state of knowledge of the health effects of chronic exposures to low concentrations of thallium

Pharmacological Treatment of Acute Psychiatric Symptoms in COVID-19 Patients: A Systematic Review and a Case Series

Delirium and psychomotor agitation are relevant clinical conditions that may develop during COVID-19 infection, especially in intensive care unit (ICU) settings. The psychopharmacological management of these conditions is receiving increasing interest in psychiatry, considering hyperkinetic delirium as one of the most common neuropsychiatries acute consequences in COVID-19 recovery patients. However, there are no actual internationally validated guidelines about this topic, due to the relatively newly introduced clinical condition; in addition, a standardized psychopharmacologic treatment of these cases is a complex goal to achieve due to the risk of both drug&ndash;drug interactions and the vulnerable conditions of those patients. The aim of this systematic review and case series is to evaluate and gather the scientific evidence on pharmacologic handling during delirium in COVID-19 patients to provide practical recommendations on the optimal management of psychotropic medication in these kinds of patients. The electronic databases PubMed, Embase and Web of Science were reviewed to identify studies, in accordance with the PRISMA guidelines. At the end of the selection process, a total of 21 studies (n = 2063) were included. We also collected a case series of acute psychomotor agitation in COVID-19 patients hospitalized in ICU. Our results showed how the symptom-based choice of the psychotropic medication is crucial, and even most of the psychotropic drug classes showed good safety, one must not underestimate the possible drug interactions and also the possible decrease in vital functions which need to be strictly monitored especially during treatment with some kinds of molecules. We believe that the evidence-based recommendations highlighted in the present research will enhance the current knowledge and could provide better management of these patients

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms

Background: Emerging aspects of the Covid-19 clinical presentation are its long-term effects, which are characteristic of the so-called “long COVID”. The aim of the present study was to investigate the prevalence of physical, psychological, and sleep disturbances and the quality of life in the general population during the ongoing pandemic. Methods: This study, based on an online survey, collected demographic data, information related to COVID-19, sleep disturbances, and quality of life data from 507 individuals. The level of sleep disturbances and quality of life was assessed through the Insomnia Severity Index (ISI) and the EuroQol-5D (EQ-5D), respectively. Results: In total, 507 individuals (M = 91 and F = 416 women) completed the online survey. The main symptoms associated with “long COVID” were headache, fatigue, muscle aches/myalgia, articular pains, cognitive impairment, loss of concentration, and loss of smell. Additionally, the subjects showed significant levels of insomnia (p &lt; 0.05) and an overall reduced quality of life (p &lt; 0.05). Conclusions: The results of the study appear in line with recent publications, but uncertainty regarding the definition and specific features of “long COVID” remains. Further studies are needed in order to better define the clinical presentation of the “long COVID” condition and related targeted treatments