Transmural gradient of glycogen metabolism in the normal rat left ventricle.

The changes of glycogen metabolism with the location of tissue within the ventricle wall have been explored in the rat myocardium. The hearts were cut in 100 microns thick serial sections and all sections were analyzed for their content in glycogen, glucose-6-phosphate, UDPG and glycogen enzymes and for glucose incorporation into glycogen and for the 2-deoxyglucose uptake after the intravenous injection of the 14C-labelled sugars. The rate of glycogen turnover was significantly higher in the subendocardial myocardium (P less than 0.01) and the levels of glucose-6-phosphate and the total (i.e. a + b) activity of glycogen phosphorylase were significantly higher in the subepicardial tissue (P less than 0.01 in both instances). No significant transmural gradient of UDPG was found and transmural changes of total (i.e. I + D) synthase activity were barely significant. These changes in glycogen metabolism may be related to regional differences in the cardiac work load and to a differentiation of the subendocardial and subepicardial heart fibers

BRESEX: On board supervision, basic architecture and preliminary aspects for payload and space shuttle interface

Data relative to the on board supervision subsystem are presented which were considered in a conference between INPE and NASA personnel, with the purpose of initiating a joint effort leading to the implementation of the Brazilian remote sensing experiment - (BRESEX). The BRESEX should consist, basically, of a multispectral camera for Earth observation, to be tested in a future space shuttle flight

Analysis of the entanglement between two individual atoms using global Raman rotations

Making use of the Rydberg blockade, we generate entanglement between two atoms individually trapped in two optical tweezers. In this paper we detail the analysis of the data and show that we can determine the amount of entanglement between the atoms in the presence of atom losses during the entangling sequence. Our model takes into account states outside the qubit basis and allows us to perform a partial reconstruction of the density matrix describing the two atom state. With this method we extract the amount of entanglement between pairs of atoms still trapped after the entangling sequence and measure the fidelity with respect to the expected Bell state. We find a fidelity $F_{\rm pairs} =0.74(7)$ for the 62% of atom pairs remaining in the traps at the end of the entangling sequence

Deterministic single-atom excitation via adiabatic passage and Rydberg blockade

We propose to use adiabatic rapid passage with a chirped laser pulse in the strong dipole blockade regime to deterministically excite only one Rydberg atom from randomly loaded optical dipole traps or optical lattices. The chirped laser excitation is shown to be insensitive to the random number \textit{N} of the atoms in the traps. Our method overcomes the problem of the $\sqrt {N}$ dependence of the collective Rabi frequency, which was the main obstacle for deterministic single-atom excitation in the ensembles with unknown \textit{N}, and can be applied for single-atom loading of dipole traps and optical lattices.Comment: 6 pages, 5 figures. Version 5 is expanded and submitted to PRA. Typo in Fig.4 corrected in Version 2. Version 3 and 4 are duplicates of V

Coherent imaging of extended objects

When used with coherent light, optical imaging systems, even diffraction-limited, are inherently unable to reproduce both the amplitude and the phase of a two-dimensional field distribution because their impulse response function varies slowly from point to point (a property known as non-isoplanatism). For sufficiently small objects, this usually results in a phase distortion and has no impact on the measured intensity. Here, we show that the intensity distribution can also be dramatically distorted when objects of large extension or of special shapes are imaged. We illustrate the problem using two simple examples: the pinhole camera and the aberration-free thin lens. The effects predicted by our theorical analysis are also confirmed by experimental observations.Comment: 10 pages, 9 figures, submitted to Optics Communication

Sublattice addressing and spin-dependent motion of atoms in a double-well lattice

We load atoms into every site of an optical lattice and selectively spin flip atoms in a sublattice consisting of every other site. These selected atoms are separated from their unselected neighbors by less than an optical wavelength. We also show spin-dependent transport, where atomic wave packets are coherently separated into adjacent sites according to their internal state. These tools should be useful for quantum information processing and quantum simulation of lattice models with neutral atoms

Vitis vinifera L. germplasm diversity: a genetic and ampelometric study in ancient vineyards in the South of Basilicata region (Italy)

The evaluation of the existing grapevines biodiversity in several areas still unexplored in Basilicata region has been carried out. A four years survey in ancient vineyards of Potenza was performed to investigate grapevine biodiversity. 85 collected accessions were subjected to genetic characterization through nine microsatellite markers. A total of 42 genotypes were obtained. The comparison with national and international databases allowed the identification of 26 accessions corresponded to new autochthonous genotypes and minor/local cultivars, in addition 16 international and national cultivars commonly cultivated in several Italian regions were found (data not shown in this work). Results indicated that minor/local cultivars were mainly cultivated in the near regions. The genetic profile of 9 new autochthonous grapevines was described here for the first time. Comparison of the genotypes, allelic frequencies, allelic sizes and ampelometric traits on mature leaves are highlighted. Conservation of new autochthonous and minor/local cultivars in germoplasm collections has been carried out including them in the germoplasm collection of CREA-VE in Arezzo in order to save grapevine biodiversity and allows further agronomical and enological evaluation

Treatment of HER2+ metastatic salivary ductal carcinoma in a pregnant woman: a case report

Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a high mortality and poor response to treatment in the advanced setting. Human epidermal growth factor 2 (HER2) can be amplified in a fraction of SDC. We describe the case of HER2+ metastatic SDC of the submandibular gland in a young pregnant woman treated by multimodal treatment (chemotherapy, radiotherapy and targeted therapy). During pregnancy, a 27-year-old woman developed SDC of the left submandibular gland with lung and bone metastases. Given the HER2 overexpression, she was treated with trastuzumab, paclitaxel and cisplatin. Since the tumor had arisen during pregnancy, triptorelin was administered after delivery. A complete remission was observed, and after eight cycles of chemotherapy, radiotherapy was started in association with trastuzumab and triptorelin. A prolonged disease control and complete visceral remission were observed. Multimodal therapy based on patient's tumor characteristics showed good clinical efficacy in the treatment of metastatic SDC

Environment and behavior: Neurochemical effects of different diets in the calf brain

open7noCalves reared for the production of white veal are subjected to stressful events due to the type of liquid diet they receive. Stress responses are mediated by three main stress-responsive cerebral regions: the prefrontal cortex, the paraventricular nucleus of the hypothalamus, and the nucleus of the solitary tract of the brainstem. In the present study, we have investigated the effects of different diets on these brain regions of ruminants using immunohistochemical methods. In this study, 15 calves were used and kept in group housing systems of five calves each. They were fed with three different diets: a control diet, a milk diet, and a weaned diet. Brain sections were immunostained to evaluate the distribution of neuronal nitric oxide synthase and myelin oligodendrocyte glycoprotein immunoreactivity in the prefrontal cortex; the expression of oxytocin in the paraventricular nucleus; and the presence of c-Fos in the A2 group of the nucleus of the solitary tract. The main results obtained indicate that in weaned diet group the oxytocin activity is lower than in control diet and milk diet groups. In addition, weaning appears to stimulate myelination in the prefrontal cortex. In summary, this study supports the importance of maintaining a nutritional lifestyle similar to that occurring in natural conditions.openPeli A.; Grandis A.; Tassinari M.; Bergamini P.F.; Tagliavia C.; Roccaro M.; Bombardi C.Peli A.; Grandis A.; Tassinari M.; Bergamini P.F.; Tagliavia C.; Roccaro M.; Bombardi C

Bose-Einstein condensation in dark power-law laser traps

We investigate theoretically an original route to achieve Bose-Einstein condensation using dark power-law laser traps. We propose to create such traps with two crossing blue-detuned Laguerre-Gaussian optical beams. Controlling their azimuthal order $\ell$ allows for the exploration of a multitude of power-law trapping situations in one, two and three dimensions, ranging from the usual harmonic trap to an almost square-well potential, in which a quasi-homogeneous Bose gas can be formed. The usual cigar-shaped and disk-shaped Bose-Einstein condensates obtained in a 1D or 2D harmonic trap take the generic form of a "finger" or of a "hockey puck" in such Laguerre-Gaussian traps. In addition, for a fixed atom number, higher transition temperatures are obtained in such configurations when compared with a harmonic trap of same volume. This effect, which results in a substantial acceleration of the condensation dynamics, requires a better but still reasonable focusing of the Laguerre-Gaussian beams