BATTISTA DA ZAGABRIA

Autor publicira sliku "Raspeće" iz Civici Musei u Udinama potpisanu od slikara "Magister Battista Zagabrensis" 1468. godine. Istovremeno se s njim povezuje i freska Raspeća na pročelju jedne kuće u Udinama.Autor publicira sliku Raspeće iz Civici Musei u Udinama, koju je potpisao "Magister Battista Zagabrensis pinxit 1468". U dokumentima se u drugoj polovini 15. stoljeća spominje nekoliko majstora s imenom Battista (krstitelj). Battista da Zagabria stanovao je u Udinama i u S. Daniele, oženio se s Chiarom (živa još 1497. godine) i s njom je imao troje djece: Martina (rođen 1467.) koji je bio poznati slikar, poznatiji kao Pellegrino da San Daniele, a spomenut i od Vasarija; Anu, koja se udala za Giovannija de\u27 Cramaris, jednog od najpoznatijih friulanskih minijaturista; drugoj se kćerci ne zna ime, ali se zna da se 1514. udala za Candida Giusta. Battista da Zagabria, slikar, drvorezbar i dekorater, bio je jedan od rijetkih hrvatskih umjetnika koji se naselio u Friulu (zlatar Giorgio di Ragusa 1481. i 1497. i Niccolo, pokojnog Petra iz Zagreba, stanovnik Udina). Hrvatski su umjetnici 1451. godine osnovali bratovštinu sv. Trojstva zajedno s njemačkim umjetnicima, a godinu dana kasnije osnovali su samo svoju pod nazivom San Girolamo degli Schiavoni. Battista da Zagabria bio je član tc bratovštine kad je obolio 1483. godine. Vjerojatno je njegova obitelj bila siromašna kad mu je 1495. godine tražila da mu se dodijeli besplatan stan kao čuvara gradskih vrata i kad je tražio višu cijenu za o l tamu sliku u udinskoj stolnici jer da je siromah. Battista je vjerojatno došao u Friul oko 1450./60. godine, baš u vrijeme razvitka umjetničke djelatnosti u Udinama i Friulu. Vjerojatno je u to vrijeme već bio formiran umjetnik, ali pod utjecajem onodobnog mletačkog slikarstva, iako je Zagreb bio poznat u to vrijeme s mnogobrojnim knjigama s minijaturama. U njegovoj se slici osjeća utjecaj friulanskih slikara iz posljednje četvrti 15. stoljeća (Dario da Pordenone, Gianfrancesco da Tolmczzo, Andrea Bellunello, Antonio da Firenze, Francesco de Alesio, Gian Pietro Iansilino). Uz Battistijevo Raspeće povezuje se i freska raspela na pročelju jedne kuće u Udinama, koja bi mu se možda mogla pripisati

Development of a wearable framework for body center of mass acceleration assessment in people with transfemoral amputation

The biomechanical study of the body center of mass (BCoM) may reveal crucial information about gait impairment in people with amputation (Al Abiad et al. 2020). The 3D kinetics of the BCoM are usua..

Definition of an optimal model based on segments' contribution for the estimation of the acceleration of the center of mass in people with lower-limb amputation

In the context of rehabilitation of people with amputation, gait analysis provides information about gait alterations. In that perspective, the body center of mass (BCoM) trajectory, or its derivat..

Safety and efficacy of tranexamic acid for prevention of obstetric haemorrhage. An updated systematic review and meta-analysis

Background. A number of clinical systematic review and meta-analysis have been published on the use of tranexamic in the obstetric setting. The aim of this meta-analysis was to evaluate the safety and effectiveness of tranexamic acid in reducing blood loss when given prior to caesarean delivery. Materials and methods. We searched the Cochrane Wounds Specialized Register, Cochrane Central, MEDLINE (through PUBMED), Embase, and SCOPUS electronic databases. We also searched clinical trials registries for ongoing and unpublished studies, and checked reference lists to identify additional studies. We used no restrictions with respect to language and date of publication. Two review authors independently performed study selection, "Risk of bias" assessment, and data extraction. Initial disagreements were resolved by discussion, or by including a third review author when necessary. Results. We found 18 randomised controlled trials (RCTs) that met our inclusion criteria. Overall, 1,764 women receiving intravenous tranexamic acid for prevention of bleeding following caesarean sections and 1,793 controls receiving placebo were enrolled in the 18 RCTs evaluated. The use of tranexamic acid compared to controls (placebo or no intervention) reduces post-partum haemorrhage >400 mL (risk ratio [RR] 0.40, 95% confidence interval [CI] 0.24-0.65; 5 trials with a total of 786 participants), severe post-partum haemorrhage >1,000 mL (RR 0.32, 95% CI: 0.12-0.84; 5 trials with a total of 1,850 participants), and need for red blood cell transfusion (RR 0.30, 95% CI: 0.18-0.49; 10 trials with a total of 1,873 participants). No particular safety concerns on the use of this antifibrinolytic agent emerged from the analysis of the 18 RCTs included. Discussion. Overall, the results of this meta-analysis support the evidence of a beneficial effect of tranexamic acid in reducing blood loss and need for blood transfusion in pregnant women undergoing caesarean section

Investigating symmetry in amputee gait through the improved harmonic ratio: influence of the stride segmentation method

The quantification of gait symmetry is extremely important in several clinical contexts. Among the many indices used to describe gait symmetry, the Harmonic Ratio (HR), which is based on a stride-b..

Estimation of 3D Body Center of Mass Acceleration and Instantaneous Velocity from a Wearable Inertial Sensor Network in Transfemoral Amputee Gait: A Case Study

The analysis of the body center of mass (BCoM) 3D kinematics provides insights on crucial aspects of locomotion, especially in populations with gait impairment such as people with amputation. In this paper, a wearable framework based on the use of different magneto-inertial measurement unit (MIMU) networks is proposed to obtain both BCoM acceleration and velocity. The proposed framework was validated as a proof of concept in one transfemoral amputee against data from force plates (acceleration) and an optoelectronic system (acceleration and velocity). The impact in terms of estimation accuracy when using a sensor network rather than a single MIMU at trunk level was also investigated. The estimated velocity and acceleration reached a strong agreement (ρ > 0.89) and good accuracy compared to reference data (normalized root mean square error (NRMSE) 0.89, NRMSE ≤ 14.0% in the mediolateral direction). Conversely, only the vertical component of the BCoM kinematics was accurately captured when considering a single MIMU. These results suggest that inertial sensor networks may represent a valid alternative to laboratory-based instruments for 3D BCoM kinematics quantification in lower-limb amputees.Don de la Fédération des Amputés de Guerre de France auprès de l'INI/CERH (contrat doctoral) Bourse mobilité cotutelle Université Franco-Italienne, VINCI C2-88

Label-free toxicology screening of primary human mesenchymal cells and iPS-derived neurons

The high-throughput, label-free Corning Epic assay has applications in drug discovery, pharmacogenomics, cell receptor signaling, cell migration, and viral titration. The utility of Epic technology for biocompatibility testing has not been well established. In manufacturing of medical devices, in vitro and in vivo biocompatibility assessments are mandatory, according to ISO 10993. The new medical device regulation MDR 745/2017 specifies that ex vivo assays that can closely recapitulate in vivo scenarios are needed to better evaluate biomedical devices. We propose herein that Epic technology\u2014which enables detection of variations in cell mass distribution\u2014is suitable for biocompatibility screening of compounds. In this study, we challenged primary human osteoblasts, endothelial cells, and neurons derived from induced pluripotent stem cells with specific concentrations of methyl methacrylate (MMA). Polymeric MMA has long been applied in cranioplasty, where it makes contact with multiple cell types. Application of Epic technology yielded real-time cytotoxicity profiles for all considered cell types. The results were compared with those from microscopic observation of the same culture plate used in the Epic analyses. The Epic assay should be further examined for its utility for cell biology, genomics, and proteomics companion assays. Our results suggest that Epic technology can be applied to biocompatibility evaluation of human cells in medical device development

Gait event detection using inertial measurement units in people with transfemoral amputation: a comparative study

In recent years, inertial measurement units (IMUs) have been proposed as an alternative to force platforms and pressure sensors for gait events (i.e., initial and final contacts) detection. While multiple algorithms have been developed, the impact of gait event timing errors on temporal parameters and asymmetry has never been investigated in people with transfemoral amputation walking freely on level ground. In this study, five algorithms were comparatively assessed on gait data of seven people with transfemoral amputation, equipped with three IMUs mounted at the pelvis and both shanks, using pressure insoles for reference. Algorithms’ performance was first quantified in terms of gait event detection rate (sensitivity, positive predictive value). Only two algorithms, based on shank mounted IMUs, achieved an acceptable detection rate (positive predictive value > 99%). For these two, accuracy of gait events timings, temporal parameters, and absolute symmetry index of stance-phase duration (SPD-ASI) were assessed. Whereas both algorithms achieved high accuracy for stride duration estimates (median errors: 0%, interquartile ranges < 1.75%), lower accuracy was found for other temporal parameters due to relatively high errors in the detection of final contact events. Furthermore, SPD-ASI derived from IMU-based algorithms proved to be significantly different to that obtained from insoles data. [Figure not available: see fulltext.].- INI/CERAH (contrat doctoral), financement par un don de la FAGF - Bourse VINCI C2-881 (mobilité cotutelle

Scoring pleurisy in slaughtered pigs using convolutional neural networks

Diseases of the respiratory system are known to negatively impact the profitability of the pig industry, worldwide. Considering the relatively short lifespan of pigs, lesions can be still evident at slaughter, where they can be usefully recorded and scored. Therefore, the slaughterhouse represents a key check-point to assess the health status of pigs, providing unique and valuable feedback to the farm, as well as an important source of data for epidemiological studies. Although relevant, scoring lesions in slaughtered pigs represents a very time-consuming and costly activity, thus making difficult their systematic recording. The present study has been carried out to train a convolutional neural network-based system to automatically score pleurisy in slaughtered pigs. The automation of such a process would be extremely helpful to enable a systematic examination of all slaughtered livestock. Overall, our data indicate that the proposed system is well able to differentiate half carcasses affected with pleurisy from healthy ones, with an overall accuracy of 85.5%. The system was better able to recognize severely affected half carcasses as compared with those showing less severe lesions. The training of convolutional neural networks to identify and score pneumonia, on the one hand, and the achievement of trials in large capacity slaughterhouses, on the other, represent the natural pursuance of the present study. As a result, convolutional neural network-based technologies could provide a fast and cheap tool to systematically record lesions in slaughtered pigs, thus supplying an enormous amount of useful data to all stakeholders in the pig industry