Croissance relative du squelette chez l'agneau. Influence du sexe et de la race

International audienc

Démence et problèmes éthiques chez les dialysés âgés.

International audienc

Fundam Clin Pharmacol

Antipsychotic drugs possess side atropinic (anticholinergic) properties that may induce several adverse drug reactions (ADRs), such as memory loss or cognitive impairment. The aim of the present study was investigating anticholinergic burden in patients treated with antipsychotic drugs. All ADR reports including at least one antipsychotic and registered between 2000 and 2015 in the Midi-Pyrenees PharmacoVigilance Database were extracted and analyzed using the Anticholinergic Duran's list. The primary objective of this cross-sectional study was to calculate anticholinergic burden in antipsychotic-treated patients; the secondary one was to investigate associated factors. Among the 1,948 reports, the average number of atropinic drugs per report was 2.4 +/- 1.4. At least one atropinic drug was found in 59.4% of reports (1,158), in addition to antipsychotic drugs. The mean anticholinergic burden per report was 3.9 +/- 2.9. A value >/= 3 was found in 61.7% of the reports. A significant association between anticholinergic burden, age and male gender of patients was found. The mean value of anticholinergic burden remained stable during the study period. This study showed high values of anticholinergic burden in patients receiving antipsychotics. Thus, considering the potential noxious clinical impact of atropinic properties on cognitive functions, an appropriate approach should be to reduce prescription of antipsychotics with a high anticholinergic burden but also coprescription of other frequently associated atropinic drugs, like antiparkinsonians, H1 antihistamines or imipraminic antidepressants in these patients

Simulation of intrinsic bipolar transistor mechanisms for future capacitor-less eDRAM on bulk substrate

International audienc

Principle of the proper use of drugs and non-drug therapies

International audienc

Principle of the proper use of drugs and non-drug therapies

International audienc

Principle of the proper use of drugs and non-drug therapies

International audienc

Differential impact of acclimation and acute water deprivation in the expression of key transcription factors in soybean roots.

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