Suspension du fond vaginal par bandelette transobturatrice postérieure (résultats anatomiques et fonctionnels après 6 ans d'expérience)

LYON1-BU Santé (693882101) / SudocSudocFranceF

Beyond production and consumption:using throughflows to untangle the virtual trade of externalities

Beaufils, T.; Berthet, E.; Ward, H.; & Wenz, L. (2023). Beyond production and consumption: Using throughflows to untangle the virtual trade of externalities. Economic Systems Research. https://doi.org/10.1080/09535314.2023.2174003 Supporting code and data This repository contains the following folders: - code : contains all Python and iPython scripts used to generate intermediate data and figures - data : contains raw and processed data used for this project. - figures : contains high-definition figures shown in the manuscript - manuscript : preprint of the manuscript and its supplementary information All results and figures can be reproduced by: 1. Downloading raw EORA data and placing them in the data/EORA/raw folder. 2. Running the scripts in the code folder in the order specified

Forest Biodiversity Patterns in France: Photo gallery

International audienc

Axillary Hidradenitis Suppurativa: A Comparison between Two Perforator Flap Reconstructive Approaches after Radical Surgical Management

International audienceBackground:Axillary hidradenitis suppurativa (HS) can result in significant functional impairment in both personal and professional lives. Stage 3 HS requires radical surgical treatment. Flap reconstruction allows for faster healing and better functional and aesthetic outcomes. We compared the results of thoracodorsal artery perforator (TDAP) and propeller inner arm artery perforator (IAAP) flap reconstructions after radical surgical treatment of axillary HS.Methods:We conducted a retrospective study that included 13 consecutive patients who underwent stage 3 axillary HS treatment between August 2015 and January 2023. Seven patients underwent reconstruction by islanded TDAP flaps, whereas six patients underwent reconstruction by propeller IAAP flaps, with one patient undergoing bilateral reconstruction. The data collected from the patient records included age, gender, smoking status, body mass index, comorbidities, operative time, defect size, flap size, hospital stay, and complications.Results:Although not statistically significant (P = 0.1923), a higher rate of flap complications is reported here with propeller IAAP flaps (42.86 %), whereas islanded TDAP flaps had no flap complications (0%). We found a statistically significant difference in operative time (P = 0.0006), defect size (P = 0.0064), and flap size (P = 0.0012) between the two groups. All patients exhibited satisfactory functional and aesthetic outcomes. Fourteen flaps were performed in total; only one case exhibited recurrence (7.14%).Conclusion:After radical surgical management, both islanded TDAP and propeller IAAP flap reconstructions offer excellent outcomes for stage 3 axillary HS. We strongly encourage our peers to consider performing perforator flaps over secondary healing for these patients with a major functional impairment

Polymer resonators sensors for detection of sphingolipid gel/fluid phase transition and melting temperature measurement

International audienceThis work describes a low-cost biophotonic sensor shaped by way of cheap processes as hybrid silicon/silica/polymer resonators able to detect biological molecule gel/fluid phase transition as lipids at very low concentration (sphingomyelin). The photonic structure is composed of specific amplified deep UV photoresist-polymer waveguides coupled by a sub-wavelength gap with racetrack microresonators allowing a low temperature-dependent operation ranging from 16 to 42 °C. The temperature dependent wavelength shift and the thermo-optic coefficient characterizing the quantified resonances and opto-geometric properties of the device have been evaluated, highlighting an enough low thermal features of the whole system for such application. With an appropriate vesicle lipid deposition process specific in biology associated to an apt experimental bio-thermo-photonic protocol (made of serial optical resonance spectra acquisitions with statistical treatments), the dynamic evolution of the sphingomyelin lipid phase transition was assessed: then, the ability to detect their own gel/fluid transition phase and melting temperature has been demonstrated with a mass product factor 10 power 7 lower than that of more conventional methods. The equilibrium of the regime of the resonators was highlighted as being broken by the dynamic of the sphingomyelin and its own phase transition prior relevant detection

French feedback from urban soil geochemical data archive to data sharing: state of mind and intent

International audienceUrban territories collect many types of geochemical and physico-chemical data relative to, e.g., soil quality or soil functions. Such data may serve for various purposes like verifying the compatibility with current or future uses, defining (pedo)geochemical backgrounds, establishing levels of exposure to soil pollutants, identifying management options for polluted sites or for excavated soils, verifying the evolution of infiltration ponds, assessing carbon storage, etc. They may also serve to prioritize soil functions and associated ecosystem services such as, e.g., soil fertility, surface and groundwater storage or supply, purification of infiltrated rainwater, etc. Gathering such data in national databases and making them available to stakeholders raises many issues that are technical, legal and social. Should all of the data be made available or only selected portions? How can access and reuse of the data be ensured in a legal fashion? Are statistical and geostatistical methods able to deal with data from heterogeneous origins, allowing their reuse for other purposes than the initial one? In this context, it is necessary to take into account scientific as well as practical considerations and to collect the societal needs of end-users like urban planners. To illustrate the complexity of these issues and ways to address them, we propose to share the French experience: •on gathering urban soil geochemical data in the French national database BDSolU. We will present how this database was created, the choices made in relation with the national context, the difficulties encountered, and the questions that are still open. •on a new interrogation system linking agricultural and urban soil databases (DoneSol and BDSolU), which have different requirements, and the corresponding standards. Such linkage based on interoperability is important in the context of changes of soil use, with for example agricultural soils becoming urbanised soils, or soils from brownfields intended for gardening. It is also necessary to ensure a territorial continuity for users. The objective is to define a robust and standardised methodology for database conceptualisation, sharing and final use by stakeholders including scientist

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia

International audienceAnthropic activities such as open pit mining, amplify the natural erosion of metals contained in the soils, particularly in New Caledonia, leading to atmospheric emission of nickel oxide nanoparticles (NiONPs). These particles are produced during extraction end up in aquatic ecosystems through deposition or leaching in the rivers. Despite alarming freshwater Ni concentrations, only few studies have focused on the cellular and molecular mechanisms of NiONPs toxicity on aquatic organisms and particularly on eels. Those fish are known to be sensitive to metal contamination, especially their liver, which is a key organ for lipid metabolism, detoxification and reproduction. The objective of this study was to assess in vitro the cytotoxic effects of NiONPs on Anguilla japonica hepatocytes, HEPA-E1. HEPA-E1 were exposed to NiONPs (0.5-5 μg/cm2) for 4 or 24 h. Several endpoints were studied: (i) viability, (ii) ROS production, SOD activity and selected anti-oxidant genes expression, (iii) inflammation, (iv) calcium signalling, (v) mitochondrial function and (vi) apoptosis. The results evidenced that NiONPs induce a decrease of cell viability and an increase in oxidative stress with a significant superoxide anion production. An increase of mitochondrial calcium concentration and a decrease of mitochondrial membrane potential were observed, leading to apoptosis. These results underline the potential toxic impact of NiONPs on eels living in mining areas. Therefore, eel exposure to NiONPs can affect their migration and reproduction in New Caledonia

Soft Matter for Integrated Photonics and Resonances: various hybrid approaches and adaptive technologies

International audienceIntegrated photonics is increasingly used in sensors and metrology applications. Moreover, the ability to develop new photonic devices through simple, low cost and mass production fabrication steps based on new materials and hybrid approaches is substantial.We will give an overview of targeted current research on integrated photonics based on various hybrid technologies so as to develop multiple families of resonant integrated structures called resonators shaped in 2D or 3D. Such devices devoted to optical resonances and sensors applications and their solving approach highlight the interest to develop specific hybrid processes such as nano-biomolecular film deposition as lipids, self-assembled and micro-fluidic devices, plasma treatments coupled with microtechnology thin layers processes using deep UV lithography and so on

Vaginal Neoplasia Induced by an Unusual Papillomavirus Subtype in a Woman with Inherited Chromosomally Integrated Human Herpesvirus Type 6A

International audienceWe describe here a case of high-grade vaginal squamous lesion in a 54-year-old woman with a papillomaviruses (HPV) genital infection that developed from a cervical low-grade squamous intraepithelial lesion (SIL) to a high-grade SIL (HSIL) on cytological examination.A colposcopy exam led to the detection of suspect vaginal lesions with granulomatous infiltrations, which were classified as a Vaginal Intra-Epithelial Neoplasia grade 2 after pathologists’ analyses. After a laser vaginal surgery and a loop excision of the transformation zone, the analyses of the anatomical pieces using a nearcomplete HPV screening panel revealed an HPV-4 infection that was not detected before in cervical smears. This HPVinfection is associated with a high human herpesvirus type 6A (HHV-6A) viral load in the same anatomical piece. The presence of an inherited chromosomally integrated HHV-6A (iciHHV-6A) was proved in this patient by real-time polymerase chain reaction on hair follicles and nail. This case suggests reconsidering both thebenign nature of low-grade lesions in the female genital tract and the well-known “good” prognosis of low-risk HPV infection, especially when iciHHV-6A is diagnosed. This clinical course insists on the benefits of the multiplex panel use or global sequencing in order to optimize biological testing sensitivity, and so enhance clinical management of infection-induced neoplasi

Axillary Hidradenitis Suppurativa: A Comparison between Two Perforator Flap Reconstructive Approaches after Radical Surgical Management

Background:. Axillary hidradenitis suppurativa (HS) can result in significant functional impairment in both personal and professional lives. Stage 3 HS requires radical surgical treatment. Flap reconstruction allows for faster healing and better functional and aesthetic outcomes. We compared the results of thoracodorsal artery perforator (TDAP) and propeller inner arm artery perforator (IAAP) flap reconstructions after radical surgical treatment of axillary HS. Methods:. We conducted a retrospective study that included 13 consecutive patients who underwent stage 3 axillary HS treatment between August 2015 and January 2023. Seven patients underwent reconstruction by islanded TDAP flaps, whereas six patients underwent reconstruction by propeller IAAP flaps, with one patient undergoing bilateral reconstruction. The data collected from the patient records included age, gender, smoking status, body mass index, comorbidities, operative time, defect size, flap size, hospital stay, and complications. Results:. Although not statistically significant (P = 0.1923), a higher rate of flap complications is reported here with propeller IAAP flaps (42.86 %), whereas islanded TDAP flaps had no flap complications (0%). We found a statistically significant difference in operative time (P = 0.0006), defect size (P = 0.0064), and flap size (P = 0.0012) between the two groups. All patients exhibited satisfactory functional and aesthetic outcomes. Fourteen flaps were performed in total; only one case exhibited recurrence (7.14%). Conclusion:. After radical surgical management, both islanded TDAP and propeller IAAP flap reconstructions offer excellent outcomes for stage 3 axillary HS. We strongly encourage our peers to consider performing perforator flaps over secondary healing for these patients with a major functional impairment