6 research outputs found

    Advances in metal-mediated solid-phase synthesis of heterocyclic compounds

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    While heterocycles are a key feature frequently found in compounds with pharmaceutical or agrochemical interest, the combination between solidsupported synthesis and organometallic chemistry has demonstrated to be a helpful tool for the preparation of that class of biologically relevant structures. From the more disclosed HĂŒisgen 1,3-dipolar cycloaddition, the palladium-catalyzed synthesis of indoles and the ruthenium carbene-mediated preparation of heterocycles by ring-closing metathesis (RCM), to the less developed use of gold and iron in polymer-supported chemistry, this survey offers an overview of the solid-phase application of metal-mediated chemistry to the generation of libraries of a variety of heterocyclic systems.Fil: la Venia, Agustina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - Rosario. Instituto de QuĂ­mica Rosario. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂ­micas y FarmacĂ©uticas. Instituto de QuĂ­mica Rosario; ArgentinaFil: Delpiccolo, Carina Maria Lujan. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - Rosario. Instituto de QuĂ­mica Rosario. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂ­micas y FarmacĂ©uticas. Instituto de QuĂ­mica Rosario; ArgentinaFil: Mata, Ernesto Gabino. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas. Centro CientĂ­fico TecnolĂłgico Conicet - Rosario. Instituto de QuĂ­mica Rosario. Universidad Nacional de Rosario. Facultad de Ciencias BioquĂ­micas y FarmacĂ©uticas. Instituto de QuĂ­mica Rosario; Argentin
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