Beyond the quantum formalism: consequences of a neural-oscillator model to quantum cognition

In this paper we present a neural oscillator model of stimulus response theory that exhibits quantum-like behavior. We then show that without adding any additional assumptions, a quantum model constructed to fit observable pairwise correlations has no predictive power over the unknown triple moment, obtainable through the activation of multiple oscillators. We compare this with the results obtained in de Barros (2013), where a criteria of rationality gives optimal ranges for the triple moment.Comment: 4 pages; to appear in the Advances in Cognitive Neurodynamics, Proceedings of the 4th International Conference on Cognitive Neurodynamics - 201

A Tale of Two Cycles: Co-Fluctuations Between UK Regions and the Euro Zone

We examine the patterns and determinants of business-cycle correlations among eleven UK regions and six euro-zone countries over the 1966-1997 period, using GMM to allow for sampling error in comparing estimated correlations. The British business cycle is found to be persistently out of phase with that of the main euro-zone economies, and the trend is towards lower correlations. We detect only minor cyclical heterogeneity among UK regions. Differences in sectoral specialisation drive some of the asymmetry in GDP fluctuations, but they do not appear significant in explaining the observed reduction in UK-EU business-cycle correlations over time.business cycles; co-fluctuations; UK regions; European monetary union; optimum currency areas

Three novel mutations in the CFTR gene identified in Galician patients

AbstractWe report three novel CFTR missense mutations detected in Spanish patients from Galicia (North West of Spain). In the first case, a patient homozygous for a novel S1045Y mutation died due to pulmonary problems. In the other two cases, both heterozygous for novel mutations combined with the F508del mutation, clinical symptoms were different depending on the mutation, detected as M595I and A107V

Transforming growth factor-β (TGF-β) maintains follicular ultrastructure and stimulates preantral follicle growth in caprine ovarian tissue cultured in vitro

O objetivo desse estudo foi investigar se o TGF-β afeta a sobrevivência, ativação e crescimento de folículos primordiais caprinos inclusos no córtex ovariano após o cultivo in vitro. Ovários de cabras foram coletados em abatedouro e fragmentos de tecido ovariano foram cultivados por um e sete dias em meio essencial mínimo alfa (α-MEM+) sozinho ou suplementado com TGF-β (1, 5, 10 ou 50ng/mL). Fragmentos ovarianos não cultivados e cultivados foram processados para análise histológica e ultraestrutural. Os resultados mostraram que, comparado ao controle fresco, houve diminuição no percentual de folículos morfologicamente normais em todos os tratamentos somente após sete dias de cultivo. O TGF-β não afetou a ativação folicular independente da concentração testada, contudo, o diâmetro folicular foi superior (P<0.05) no tratamento com 10ng/mL de TGF-β quando comparado ao controle fresco e aos demais tratamentos. Além disso, essa mesma concentração manteve a ultraestrutura normal dos folículos após sete dias de cultivo. Em conclusão, o TGF-β apresentou efeito adicional no crescimento folicular e na manutenção da integridade ultraestrutural de folículos pré-antrais caprinos inclusos no tecido ovariano quando utilizado na concentração de 10ng/mL durante sete dias de cultivo.The objectives of this study were to investigate whether TGF-β affect the survival, activation and further growth of goat primordial follicles enclosed in ovarian cortex after in vitro culture. Goat ovaries were collected from an abattoir and pieces of ovarian tissues were cultured for one or seven days in a supplemented alpha Minimum Essential Medium, alone or containing TGF-β (1, 5, 10 or 50ng/mL). Ovarian tissues from the fresh control as well as those cultured were processed for histological and ultrastructural studies. The results showed that when compared with fresh control, there was decrease in the percentages of histologically normal follicles in all treatments only after seven days culture. TGF-β did not affect the activation of preantral follicles regardless of its concentration, however, larger follicles diameter (P<0.05) was observed using 10ng/mL TGF-β than in the fresh control and other treatments. Moreover, this concentration maintained the normal ultrastructure after seven days of culture. In conclusion, TGF-β showed additional effect on the follicle growth and the maintenance of ultrastructural integrity of goat preantral follicles enclosed in ovarian tissue when used at 10ng/mL during seven days of culture

Cylindrical thin-shell wormholes

A general formalism for the dynamics of non rotating cylindrical thin-shell wormholes is developed. The time evolution of the throat is explicitly obtained for thin-shell wormholes whose metric has the form associated to local cosmic strings. It is found that the throat collapses to zero radius, remains static or expands forever, depending only on the sign of its initial velocity.Comment: 10 page

Dilatonic global strings

We examine the field equations of a self-gravitating global string in low energy superstring gravity, allowing for an arbitrary coupling of the global string to the dilaton. Massive and massless dilatons are considered. For the massive dilaton the spacetime is similar to the recently discovered non-singular time-dependent Einstein self-gravitating global string, but the massless dilaton generically gives a singular spacetime, even allowing for time-dependence. We also demonstrate a time-dependent non-singular string/anti-string configuration, in which the string pair causes a compactification of two of the spatial dimensions, albeit on a very large scale.Comment: 18 pages RevTeX, 3 figures, references amende

Prediction of intensive care admission and hospital mortality in COVID-19 patients using demographics and baseline laboratory data

Introduction: Optimized allocation of medical resources to patients with COVID-19 has been a critical concern since the onset of the pandemic. Methods: In this retrospective cohort study, the authors used data from a Brazilian tertiary university hospital to explore predictors of Intensive Care Unit (ICU) admission and hospital mortality in patients admitted for COVID-19. Our primary aim was to create and validate prediction scores for use in hospitals and emergency departments to aid clinical decisions and resource allocation. Results: The study cohort included&nbsp;3,022&nbsp;participants, of whom&nbsp;2,485&nbsp;were admitted to the ICU; 1968&nbsp;survived, and&nbsp;1054&nbsp;died in the hospital. From the complete cohort, 1,496&nbsp;patients were randomly assigned to the derivation sample and&nbsp;1,526&nbsp;to the validation sample. The final scores included age, comorbidities, and baseline laboratory data. The areas under the receiver operating characteristic curves were very similar for the derivation and validation samples. Scores for ICU admission had a&nbsp;75%&nbsp;accuracy in the validation sample, whereas scores for death had a&nbsp;77%&nbsp;accuracy in the validation sample. The authors found that including baseline flu-like symptoms in the scores added no significant benefit to their accuracy. Furthermore, our scores were more accurate than the previously published NEWS-2 and 4C Mortality Scores. Discussion and conclusions: The authors developed and validated prognostic scores that use readily available clinical and laboratory information to predict ICU admission and mortality in COVID-19. These scores can become valuable tools to support clinical decisions and improve the allocation of limited health resources