Revisiting context-aware component interconnection

Software connectors are external coordination devices which ensure the flow of data and enforce synchronization constraints within a component’s network. The specification of software connectors through which context dependent behaviour is correctly propagated remains an open, non trivial issue in their semantics. This paper, building on previous work by the authors, revisits this problem and introduces a model in which context awareness is suitably handled

Indexação de plantas básicas de citros da Embrapa Mandioca e Fruticultura para a presença de viróides.

Os citros são hospedeiros naturais de espécies de viróides: viróide da exocorte dos citros (Citrus exocortis viroid, CEVd), viróide do nanismo do lúpulo (Hop stunt viroid, HSVd), Citrus bark cracking viroid (CBCVd), viróide da folha curvada dos citros (Citrus bent leaf viroid, CBLVd), viróide do nanismo dos citros (Citrus dwarfing viroid, CDVd) e, mais recentemente, também foi descrita a ocorrência do Citrus Viroid V (CVd-V) e Citrus viroid VI (CVd-VI). Somente o CEVd e variantes do HSVd são agentes causais de doenças, exocorte e xiloporose, respectivamente. No Brasil já foram identificados as espécies CEVd, HSVd e o CDVd

Profile of emergency department overuse in hospitalized patients with pulmonary disease and its impact on mortality

Funding Information: We would like to thank Cláudia Coluna and Sara Salgado for the review of the manuscript. The final linguistic review was also conducted by W4Research, a proofreading company based in Lisbon, Portugal. This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2023 Sociedade Portuguesa de PneumologiaIntroduction and objectives: Portugal is one of the countries with the highest number of visits to the emergency department (ED), 31% classified as “non-urgent” or “avoidable.” The objectives of our study were to evaluate the size and characteristics of patients with pulmonary disease who overuse the ED, and identify factors associated with mortality. Materials and methods: A retrospective cohort study was conducted, based on the medical records of ED frequent users (ED-FU) with pulmonary disease who attended a university hospital center in the northern inner city of Lisbon from January 1 to December 31, 2019. To evaluate mortality, a follow-up until December 31, 2020 was performed. Results: Over 5,567 (4.3%) patients were identified as ED-FU and 174 (0.14%) had pulmonary disease as the main clinical condition, accounting for 1,030 ED visits. 77.2% of ED visits were categorized as “urgent/very urgent.” A high mean age (67.8 years), male gender, social and economic vulnerability, high burden of chronic disease and comorbidities, with a high degree of dependency, characterized the profile of these patients. A high proportion (33.9%) of patients did not have a family physician assigned and this was the most important factor associated with mortality (p<0.001; OR: 24.394; CI 95%: 6.777–87.805). Advanced cancer disease and autonomy deficit were other clinical factors that most determined the prognosis. Conclusions: Pulmonary ED-FU are a small group of ED-FU who constitute an aged and heterogeneous group with a high burden of chronic disease and disability. The lack of an assigned family physician was the most important factor associated with mortality, as well as advanced cancer disease and autonomy deficit.proofinpres

Reference concentrations for trace elements in urine for the Brazilian population based on q-ICP-MS with a simple dilute-and-shoot procedure

Biomonitoring of trace elements is of critical importance in human health assessment. However, trace element concentrations in biological fluids are affected by environmental and physiological parameters, and therefore considerable variations can occur between specific population subgroups. Brazil is a large country with large environmental diversity and with a limited knowledge of the reference values (baseline data) for trace elements in biological fluids. Atomic absorption spectrometry (AAS) and inductively coupled plasma emission spectrometry (ICP-OES) are still the dominant analytical techniques used for biomonitoring trace element analysis in clinical specimens. However, the use of ICP-MS is becoming more usual in clinical laboratory analysis. Then, we evaluated here a simple dilute-and-shoot method for sequential determination of Al, Ba, Be, Cd, Co, Cu, Cs, Mn, Ni, Pb, Pt, Sb, Se, Sn, Tl and U in urine by quadrupole inductively coupled plasma mass spectrometry (q-ICP-MS). Urine samples (500 µL) were accurately pipetted into conical tubes (15 mL) and diluted to 10 mL with a solution containing 0.5 % (v/v) HNO3 + 0.005% (v/v) Triton X-100. Diluted urine samples also contain rhodium, iridium and yttrium added as internal standards. After that, samples were directly analyzed by ICP-MS against matrix-matching calibration. Method detection limit (3s, n = 20) were in the ng L-1 range for all analytes. The method was applied to the analysis of 412 ordinary urine samples from Brazilian healthy and non-exposed subjects to establish reference values. Data validation was provided by the analysis of the standard reference material (SRM) 2670a toxic elements in urine (freeze-dried) (high and low levels) from the National Institute of Standards and Technology (NIST) and reference urine samples from the trace elements intercomparison program operated by the Institut National de Sante' Publique du Quebec, Canada.O biomonitoramento de elementos químicos é de extrema importância na avaliação da saúde humana. Entretanto, as concentrações dos elementos químicos nos fluidos biológicos são afetadas por parâmetros ambientais e fisiológicos e, consequentemente, consideráveis variações podem ocorrer entre subgrupos de populações específicas. O Brasil é um país com ampla diversidade ambiental e existe limitado conhecimento de valores de referência para elementos químicos em fluidos biológicos. A espectrometria de absorção atômica (AAS) e a espectrometria de emissão ótica com plasma acoplado indutivamente (ICP-OES) ainda são as técnicas analíticas mais comumente empregadas no biomonitoramento de elementos químicos em amostras clínicas. Entretanto, o uso da espectrometria de massas com plasma acoplado indutivamente (ICP-MS) está se tornando a cada dia mais comum nos laboratórios clínicos. Neste estudo, foi avaliado um método rápido envolvendo simples diluição da amostra para determinação de Al, Ba, Be, Cd, Co, Cu, Cs, Mn, Ni, Pb, Pt, Sb, Se, Sn, Tl e U em urina por ICP-MS. Amostras de urina (500 &#956;L) foram pipetadas em frascos cônicos de 15 mL e diluídas para 10 mL com uma solução contendo 0,5 % (v/v) HNO3 + 0,005% (v/v) Triton X-100. Ródio, irídio e ítrio foram adicionados como padrões internos. Em seguida, as amostras foram diretamente analisadas por ICP-MS com calibração por ajuste de matriz. Os limites de detecção do método (3s, n = 20) foram da ordem de ng L-1 para todos os analitos em estudo. O método foi aplicado para a análise de 412 amostras de urina de brasileiros saudáveis e não expostos ambientalmente ou ocupacionalmente a metais para o estabelecimento de valores de referência na população brasileira. A validação dos resultados foi acompanhada pela análise de material de referência certificada de urina (SRM) 2670a proveniente do National Institute of Standards and Technology (NIST) e de materiais de referência provenientes do Institut National de Sante' Publique Du Quebec, no Canadá.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Termoterapia e premunizaçâo para o Citrus Tristeza Vírus (CTV) ,como ferramentas à certificação fitossanitaria de citros na Bahia.

A tristeza dos citros causada pelo CTV é considerada uma das doenças mais importantes para citricultura brasileira porque é endêmica em nossas condições. O manejo da doença nos pais é realizado pela utilização de porta-enxertos tolerante e premunização de espécies e variedades intolerantes com estirpes menos severas do vírus

Causas de variação da produção de leite em um rebanho da Raça Holandesa em São Carlos, SP.

0 objetivo deste trabalho foi avaliar a importancia dos efeitos de ano de parto (AP), estacao de parto (EP), grupo genetico (GG), sexo do bezerro (SB), causa de secagem (CS), idade da vaca ao parto (IP, em meses) e duracao do periodo de lactacao (DL, em (dias) e de touro (PAI), na producao de leite (PL), em um rebanho da raça Holandesa. Um total de 684 observacoes, provenientes de 267 vacas criadas em um modelo fisico de sistema de producao de leite mantido na Embrapa - Centro de Pesquisa de Pecuaria do Sudeste, São Carlos, SP foi incluido nas analises. Os dados foram coletados no período de outubro de 1984 a dezembro de 1993 e analisados pelo método dos quadrados mínimos por meio de um modelo incluindo os efeitos fixos de AP, EP, GG, SB e CS, os efeitos lineares quadrático de IP e DL como covariaveis e o efeito aleatório de PAI. Houve efeitos de AP, EP, CS, IP (linear e quadrático), DL (linear e quadrático) e PAI sobre a PL. As variáveis GG e SB não influenciaram a PL. No período estudado, houve aumento linear da PL de 347,6~22,02 kg de leite/lactação ano. As vacas com lactações iniciadas no verão (janeiro-março) foram menos produtivas (4.325~82 kg) que as com lactações iniciadas nas demais estações do ano (4795+49 kg). As vacas com lactações encerradas por motivo de pré-parto apresentaram maior PL (4903+78 kg) que as com lactações encerradas por baixa produção/outras causas (4452~61 kg). A PL foi influenciada pelos efeitos linear (18,86+2,39 kg/mês) e quadrático (-0,2934+0,04S6 kg/mê da idade da vaca ao parto. Houve efeitos linear (15,83+0,41 kg/dia) e quadrático (-0,0057+-0,Ü023 kg/dia'-) da durar;ao do período de lactação sobre a PL

Antimicrobial activity of fruit packages coated with nanomaterials based in metal-ions zeolites

The transport and storage of fruits is frequently compromised by microbial contaminations, especially during the delivery of these perishable foods to the public. The development of smart packages against microbial contaminations is an alternative of great interest to help controlling post-harvest diseases. The incorporation of nanomaterials, such as metal-ions zeolites with antimicrobial properties, in the semi-rigid alveolar structure for fruits transport/storage could allow the preservation of fruit with safety and quality, by inhibiting/reducing the growth of microrganisms. In this work, metal-ions zeolite nanomaterials were incorporated on the packaging material and the antibacterial activity was tested against Escherichia coli and Staphylococcus aureus. The package material exhibited good antimicrobial activity against the two bacteria (Figure 1), which are promising results for industrial application.info:eu-repo/semantics/publishedVersio

Physical exercise on inflammatory markers in type 2 diabetes patients: a systematic review of randomized controlled trials

Background. Type 2 diabetes mellitus (T2DM) is a serious disease associated with high morbidity and mortality. Scientific findings showed that physical exercise is an option for treatment of these patients. This study's objective is to investigate the effects of supervised aerobic and/or resistance physical training on inflammatory markers in subjects with T2DM. Methods. A systematic review was conducted on four databases, MEDLINE, CENTRAL, LILACS, and Scopus, and manual search from 21 to 30 November 2016. Randomized clinical trials involving individuals diagnosed with T2DM, who have undergone supervised training protocols, were selected in this study. Results. Eleven studies were included. Studies that evaluated control group versus aerobic exercise reported controversial results about the effectiveness of physical training in modifying C-reactive protein (CRP) and cytokine levels. The only variable analyzed by the six studies in comparison to the control group versus resistance exercise was CRP. This protein showed no significant difference between groups. Between the two modes of exercise (aerobic and resistance), only one study demonstrated that aerobic exercise was more effective in reducing CRP. Conclusion. The evidence was insufficient to prove that aerobic or resistance exercise improves systemic levels of inflammatory markers in patients with T2DM