2 research outputs found
Inhaled dry salt micro particles in the treatment of bronchopulmonary dysplasia: a five case series report
Background. Despite current medical advances,
to this day there is no single medical
intervention to effectively prevent or
treat bronchopulmonary dysplasia (BPD)
in both preterm and term infants. Along
with protective ventilation strategies, various
drugs are being used or are being researched
at this very moment, with the sole
purpose of improving the general outcome
for these patients. Inhaled dry salt micro
particles therapy is now one of them.
Materials and methods. This report presents
five patients, diagnosed with severe
BPD. All of them received, complementary
to classical BPD management and
respiratory support, continuous inhaled
dry salt micro particles, via SaltMed cartridges,
for a period of 12 to 30 days. After
only 24 hours of administration, we were
able to observe a significant improvement
in respiratory function and dynamics. It
was possible to use a lower fraction of inspired
oxygen (FiO2), mean airway pressure
(MAP) and peak inspiratory pressure
(PIP) in all mechanically ventilated patients.
Higher tidal volumes were recorded
and we observed improvement in oxygenation
indexes.
Conclusion. Continuously inhaled dry salt
micro particles, administered complementary
to classic BPD management, could
improve respiratory and overall morbidity
and mortality in infants with any form
of BPD. Further study of these possible
effects is needed, as there is no data published
on this matter so far
Hemadsorption with Adult CytoSorb® in a Low Weight Pediatric Case
Cytokine adsorber (CytoSorb) has been used successfully as adjunctive treatment for adult patients with elevated cytokine levels in the setting with severe sepsis and septic shock and to reduce blood myoglobin, unconjugated bilirubin, and conjugated bilirubin. In this article we present the case of a nine-month-old male infant who was admitted to the NICU due to sepsis after cardiac surgery, Fallot tetralogy, and multisystem organ failure (MSOF) including liver failure and renal failure which was successfully treated by a combination of continuous hemodiafiltration (HDF) and hemadsorption with CytoSorb. HDF was safe and effective from the first day for urea removal, but the patient’s bilirubin levels kept increasing gradually, culminating on the 9th day with a maximum value of 54 mg/dL of total bilirubin and 31.67 mg/dL of direct bilirubin when we performed hemadsorption with CytoSorb. Over the 49-hour period of hemadsorption, the total bilirubin value decreased from 54 to 14 mg/dL, and the patient’s general status improved considerably accompanied by a rapid drop of aminotransferases. Hemodynamic status has been improved as well and inotropes dropped rapidly. The patient’s ventilation settings improved during CytoSorb treatment permitting weaning the patient from mechanical ventilation after five days of hemadsorption. The patient was discharged home after 34 days of hospitalization, in a good general status