3 research outputs found

    Vanadyl(IV) acetate, a new reusable catalyst for acetylation of alcohols

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    Vanadyl(IV) acetate is found to be an efficient catalyst for acetylation of primary, secondary, tertiary and steroidal alcohols in the presence of acetic anhydride in quantitative yields. The catalyst is recovered quantitatively and re-used

    Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

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    Five new tetracaine analogues were synthesized and evaluated for potency of blockade of cyclic nucleotide-gated channels relative to a multiply charged tetracaine analogue described previously (4). Increased positive charge at the tertiary amine end of tetracaine results in higher potency and voltage dependence of block. Modifications that reduce the hydrophobic character at the butyl tail are deleterious to block. The tetracaine analogues described here have apparent affinities for CNGA1 channels that vary over nearly 8 orders of magnitude
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