Esterified Hyaluronic Acid and Autologous Bone in the Surgical Correction of the Infra-Bone Defects

We study the osteoinductive effect of the hyaluronic acid (HA) by using an esterified low-molecular HA preparation (EHA) as a coadjuvant in the grafting processes to produce bone-like tissue in the presence of employing autologous bone obtained from intra-oral sites, to treat infra-bone defects without covering membrane

Treatment of horizontal root fracture: a case report

Radicular fractures in permanent teeth are uncommon injuries among dental traumas, being only 0.5-7% of the cases. Traumatic dental injuries occur more frequently in young patients, and vary in severity from enamel fractures to avulsions

Microbiota and Obesity: Where Are We Now?

Simple Summary Emerging new data reported in the international scientific literature show that specific alterations in the human gut microbiota are characteristic in obesity and obesity-related metabolic diseases. Obesity is conditioned by a multitude of factors, and the microbiota is certainly an important player. The analysis of the data obtained from experimental studies allow us to hypothesize that changes in the composition of the microbiota may be the cause, and not simply the consequence, of alterations in human metabolism. Clinical trials on wide samples that investigate the role of diet-induced modulation of the gut microbiota on the host metabolism are needed to understand the interactions at the molecular level for the observed correlations between metabolism and microbiota changes. Abstract Genetic and environmental factors are underlying causes of obesity and other metabolic diseases, so it is therefore difficult to find suitable and effective medical treatments. However, without a doubt, the gut microbiota—and also the bacteria present in the oral cavity—act as key factors in the development of these pathologies, yet the mechanisms have not been fully described. Certainly, a more detailed knowledge of the structure of the microbiota—composition, intra- and inter-species relationships, metabolic functions—could be of great help in counteracting the onset of obesity. Identifying key bacterial species will allow us to create a database of “healthy” bacteria, making it possible to manipulate the bacterial community according to metabolic and clinical needs. Targeting gut microbiota in clinical care as treatment for obesity and health-related complications—even just for weight loss has become a real possibility. In this topical review we provide an overview of the role of the microbiota on host energy homeostasis and obesity-related metabolic diseases, therefore addressing the therapeutic potential of novel and existing strategies (impact of nutrition/dietary modulation, and fecal microbiota transplantation) in the treatment of metabolic disease

Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine.

Since their first isolation and characterization by Friedenstein et al. in 1974 [1], mesenchymal stem cells (MSCs) were proven essential for tissue regeneration and homeostasis

Lichen striatus successfully treated with oral cyclosporine

Lichen striatus is an acquired, benign, linear inflammatory dermatosis characterized by a sudden skin eruption along Blaschkoâs lines that usually is not associated with specific etiologic agents. In most cases, it is a self-limited dermatosis, but may relapse. Topical steroids are its first-line therapy, but this treatment is not always effective. We describe the case of a 45-year-old woman affected by a lichen striatus on her right limb resistant to topical corticosteroid therapy. The patient was successfully treated with cyclosporine (4 mg/kg/die) for 4 weeks with no recurrence of the dermatitis during the subsequent 1-year follow-up period

Tissuue Engineering in Maxillar Sinus Lifting: A Comparation of Differents Grafts and Confocal Laser Scanning Microscopic Evaluation

Bone is a specialized connective tissue, most prominently characterized by its mineralized organic matrix that imparts the physical properties that allow bone tissue to resist load, to support functional organs, and to protect highly sensitive body parts. Bone loss and bone damage may occur as a result of genetic conditions, infectious diseases, tumours, and trauma. Bone healing and repair, involves integrative activity of native tissues and living cells, and lends itself to the incorporation of naturally derived or biocompatible synthetic scaffolds, aimed at replacing missing or damaged osseous tissues. There are several modalities of bone regeneration including tissue engineering, guided bone regeneration, distraction ontogenesis, and bone grafting. This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone regenerative therapy

Philosophy and Hippocratic Ethic in Ancient Greek Society: Evolution of Hospital - Sanctuaries

The aim of this paper is to offer a new perspective of the Hippocratic thought and how it influenced the evolution of the medical art till now, highlighting the ethical aspects and hospital born from ancient temples and sanctuary. Ethics is defined as a set of values, principles, and rules that regulate human behavior and relate to how human actions can significantly affect not only their own lives but also the lives of others. The essence of a culture can be perceived by the philosophy and the means by which is placed against the illness and its treatment. In this sense, the medical anthropology of every age is an indicator of its culture and help us understand its basic dimensions such as life and death

Candida albicans and oral carcinogenesis. A brief review.

Current medical knowledge and research on patients’ management are still evolving, and several protocols on minimizing risk of infection by Candidaspp.among the population have developed. The aim of this workis to reviewthe epidemiological and biomolecular characteristics and the various histopathological carcinogenesis hypothesis mechanisms that can occur during Candida albicansinfections. Current evidence from the literature on the role of C. albicansduring potentially malignant oral disorders and oral cancer has been sought.Thus, these biomolecular processes can give or contribute to benign lesions,also in precancerous or cancerous situations. Alongside this, the physiological microorganism oral flora (microbiota) can play a crucial role in maintaining oral health during those infections and therefore avoid carcinogenesis

The Human Respiratory System and its Microbiome at a Glimpse

The recent COVID-19 pandemic promoted efforts to better understand the organizationof the respiratory microbiome and its evolution from birth to adulthood and how it interacts withexternal pathogens and the host immune system. This review aims to deepen understanding of theessential physiological functions of the resident microbiome of the respiratory system on human healthand diseases. First, the general characteristics of the normal microbiota in the different anatomicalsites of the airways have been reported in relation to some factors such as the effect of age, diet andothers on its composition and stability. Second, we analyze in detail the functions and compositionand the correct functionality of the microbiome in the light of current knowledge. Several studiessuggest the importance of preserving the micro-ecosystem of commensal, symbiotic and pathogenicmicrobes of the respiratory system, and, more recently, its relationship with the intestinal microbiome,and how it also leads to the maintenance of human health, has become better understood