516 research outputs found
Bioeconomic Model of Rainbow Trout (\u3cem\u3eOncorhynchus mykiss\u3c/em\u3e) and Humpback Chub (\u3cem\u3eGila cypha\u3c/em\u3e) Management in the Grand Canyon
The Colorado River, from Glen Canyon Dam (GCD) to the Little Colorado River (LCR) confluence, includes both non-native Rainbow Trout (Oncorhynchus mykiss) and endangered native Humpback Chub (Gila cypha). While both Rainbow Trout and Humpback Chub are valued fish species in this system, Rainbow Trout can have a negative effect on Humpback Chub survival. We developed a bioeconomic model to determine management actions that minimize the costs of controlling Rainbow Trout abundance subject to achieving Humpback Chub population goals. The model is compartmentalized into population and management components. The population component characterizes the stylized dynamics of Rainbow Trout and Humpback Chub from GCD to the LCR confluence within the Colorado River. The management component of the model identifies Rainbow Trout mechanical removal strategies that achieve average annual juvenile Humpback Chub survival targets while minimizing management costs. This research is an interdisciplinary effort combining biological models and economic methods to address federal, state and tribal stakeholder resource goals related to Rainbow Trout and Humpback Chub management in this complex social-ecological system
Transcriptional profiling identifies the metabolic phenotype of gonococcal biofilms
Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, often leading to chronic infections. One factor contributing to this may be biofilm formation. N. gonorrhoeae can form biofilms on glass and plastic surfaces. There is also evidence that biofilm formation may occur during natural cervical infection. To further study the mechanism of gonococcal biofilm formation, we compared transcriptional profiles of N. gonorrhoeae biofilms to planktonic profiles. Biofilm RNA was extracted from N. gonorrhoeae 1291 grown for 48 h in continuous-flow chambers over glass. Planktonic RNA was extracted from the biofilm runoff. In comparing biofilm with planktonic growth, 3.8% of the genome was differentially regulated. Genes that were highly upregulated in biofilms included aniA, norB, and ccp. These genes encode enzymes that are central to anaerobic respiratory metabolism and stress tolerance. Downregulated genes included members of the nuo gene cluster, which encodes the proton-translocating NADH dehydrogenase. Furthermore, it was observed that aniA, ccp, and norB insertional mutants were attenuated for biofilm formation on glass and transformed human cervical epithelial cells. These data suggest that biofilm formation by the gonococcus may represent a response that is linked to the control of nitric oxide steady-state levels during infection of cervical epithelial cells
Stimulus-dependent maximum entropy models of neural population codes
Neural populations encode information about their stimulus in a collective
fashion, by joint activity patterns of spiking and silence. A full account of
this mapping from stimulus to neural activity is given by the conditional
probability distribution over neural codewords given the sensory input. To be
able to infer a model for this distribution from large-scale neural recordings,
we introduce a stimulus-dependent maximum entropy (SDME) model---a minimal
extension of the canonical linear-nonlinear model of a single neuron, to a
pairwise-coupled neural population. The model is able to capture the
single-cell response properties as well as the correlations in neural spiking
due to shared stimulus and due to effective neuron-to-neuron connections. Here
we show that in a population of 100 retinal ganglion cells in the salamander
retina responding to temporal white-noise stimuli, dependencies between cells
play an important encoding role. As a result, the SDME model gives a more
accurate account of single cell responses and in particular outperforms
uncoupled models in reproducing the distributions of codewords emitted in
response to a stimulus. We show how the SDME model, in conjunction with static
maximum entropy models of population vocabulary, can be used to estimate
information-theoretic quantities like surprise and information transmission in
a neural population.Comment: 11 pages, 7 figure
Numerical Solution of Differential Equations by the Parker-Sochacki Method
A tutorial is presented which demonstrates the theory and usage of the
Parker-Sochacki method of numerically solving systems of differential
equations. Solutions are demonstrated for the case of projectile motion in air,
and for the classical Newtonian N-body problem with mutual gravitational
attraction.Comment: Added in July 2010: This tutorial has been posted since 1998 on a
university web site, but has now been cited and praised in one or more
refereed journals. I am therefore submitting it to the Cornell arXiv so that
it may be read in response to its citations. See "Spiking neural network
simulation: numerical integration with the Parker-Sochacki method:" J. Comput
Neurosci, Robert D. Stewart & Wyeth Bair and
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717378
Markov analysis of stochastic resonance in a periodically driven integrate-fire neuron
We model the dynamics of the leaky integrate-fire neuron under periodic
stimulation as a Markov process with respect to the stimulus phase. This avoids
the unrealistic assumption of a stimulus reset after each spike made in earlier
work and thus solves the long-standing reset problem. The neuron exhibits
stochastic resonance, both with respect to input noise intensity and stimulus
frequency. The latter resonance arises by matching the stimulus frequency to
the refractory time of the neuron. The Markov approach can be generalized to
other periodically driven stochastic processes containing a reset mechanism.Comment: 23 pages, 10 figure
Leibniz's Infinitesimals: Their Fictionality, Their Modern Implementations, And Their Foes From Berkeley To Russell And Beyond
Many historians of the calculus deny significant continuity between
infinitesimal calculus of the 17th century and 20th century developments such
as Robinson's theory. Robinson's hyperreals, while providing a consistent
theory of infinitesimals, require the resources of modern logic; thus many
commentators are comfortable denying a historical continuity. A notable
exception is Robinson himself, whose identification with the Leibnizian
tradition inspired Lakatos, Laugwitz, and others to consider the history of the
infinitesimal in a more favorable light. Inspite of his Leibnizian sympathies,
Robinson regards Berkeley's criticisms of the infinitesimal calculus as aptly
demonstrating the inconsistency of reasoning with historical infinitesimal
magnitudes. We argue that Robinson, among others, overestimates the force of
Berkeley's criticisms, by underestimating the mathematical and philosophical
resources available to Leibniz. Leibniz's infinitesimals are fictions, not
logical fictions, as Ishiguro proposed, but rather pure fictions, like
imaginaries, which are not eliminable by some syncategorematic paraphrase. We
argue that Leibniz's defense of infinitesimals is more firmly grounded than
Berkeley's criticism thereof. We show, moreover, that Leibniz's system for
differential calculus was free of logical fallacies. Our argument strengthens
the conception of modern infinitesimals as a development of Leibniz's strategy
of relating inassignable to assignable quantities by means of his
transcendental law of homogeneity.Comment: 69 pages, 3 figure
Stevin numbers and reality
We explore the potential of Simon Stevin's numbers, obscured by shifting
foundational biases and by 19th century developments in the arithmetisation of
analysis.Comment: 22 pages, 4 figures. arXiv admin note: text overlap with
arXiv:1104.0375, arXiv:1108.2885, arXiv:1108.420
South Korea's automotive labour regime, Hyundai Motors’ global production network and trade‐based integration with the European Union
This article explores the interrelationship between global production networks(GPNs) and free trade agreements (FTAs) in the South Korean auto industry and its employment relations. It focuses on the production network of the Hyundai Motor Group (HMG) — the third biggest automobile manufacturer in the world — and the FTA between the EU and South Korea. This was the first of the EU’s ‘new generation’ FTAs, which among other things contained provisions designed to protect and promote labour standards. The article’s argument is twofold. First, that HMG’s production network and Korea’s political economy (of which HMG is a crucial part) limited the possibilities for the FTA’s labour provisions to take effect. Second, that the commercial provisions in this same FTA simultaneously eroded HMG’s domestic market and corporate profitability, leading to adverse consequences for auto workers in the more
insecure and low-paid jobs. In making this argument, the article advances a multiscalar conceptualization of the labour regime as an analytical intermediary between GPNs and FTAs. It also provides one of the first empirical studies of the EU–South Korea FTA in terms of employment relations, drawing on 105 interviews with trade unions, employer associations, automobile companies and state officials across both parties
Elastohydrodynamic lubrication properties and friction behaviors of several ester base stocks
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