9 research outputs found
Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells
- Author
- A Chorny
- A L Frantz
- A Nenci
- A Phalipon
- AJ Fusco
- AJ Macpherson
- B Coornaert
- B Stein
- BA Duerkop
- C S Kaetzel
- C Zaph
- CS Kaetzel
- CY Ito
- D Artis
- D Haller
- E Ainbinder
- E Dejardin
- E W Rogier
- F-E Johansen
- G Bonizzi
- G Bonizzi
- G Xiao
- GD Bren
- GD Wu
- H Sakurai
- H Schjerven
- H Schjerven
- H Schjerven
- HS Lee
- IA Udalova
- IN Norderhaug
- JC Sirard
- JD Dignam
- JW Pierce
- KA Steinbrecher
- M E C Bruno
- M Rumbo
- M Travert
- M Viswanathan
- ME Spehlmann
- MEC Bruno
- MEC Bruno
- MEC Bruno
- MS Hayden
- N Takenouchi-Ohkubo
- O Shibolet
- PC Cogswell
- PJ Sansonetti
- R Arsenescu
- S Ryser
- SF Greer
- T Boutros
- TA Schneeman
- VJ Blanch
- ZB Yilmaz
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
The polymeric immunoglobulin receptor (pIgR) transports IgA antibodies across intestinal epithelial cells (IECs). Expression of pIgR is upregulated by proinflammatory signaling pathways via activation of nuclear factor-κB (NF-κB). Here, we examined the contributions of the RelA-dependent classical and RelB-dependent alternative pathways of NF-κB to pIgR regulation in the HT-29 human IEC line following stimulation with tumor necrosis factor (TNF), lipopolysaccharide (LPS; Toll-like receptor 4 (TLR4) ligand), and polyinosinic: polycytidylic acid (pIC; TLR3 ligand). Whereas induction of proinflammatory genes such as interleukin-8 (IL-8) required only RelA, pIgR expression was regulated by complex mechanisms that involved both RelA and RelB. Upregulation of pIgR expression by ligation of the lymphotoxin-β receptor suggested a direct role for the alternative NF-κB pathway. Inhibition of mitogen-activated protein kinases reduced the induction of IL-8, but enhanced the induction of pIgR by TNF and TLR signaling. Regulation of pIgR through unique signaling pathways could allow IECs to sustain high levels of IgA transport while limiting the proinflammatory responses
Dyslipidemia in Niddm: New Insights
- Author
- A Fontbonne
- BA Griffin
- BA Griffin
- BO Schneeman
- CY-D Ida
- DM Zilversmit
- GF Lewis
- GM Reaven
- HA Barakat
- HJ Parra
- HN Ginsberg
- J Johansson
- J-C Fruchart
- JR McNamara
- JR Patsch
- JV Selby
- KR Feingold
- LBF Chang
- M Laakso
- M Syvänne
- M Syvänne
- M-R Taskinen
- MA Austin
- MA Austin
- MA Austin
- MA Austin
- MC Cheung
- MW Stewart
- P Puchois
- PHE Groot
- PJ Blanche
- RM Krauss
- RM Krauss
- TA Musliner
- TC Ooi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1995
- Field of study
Effect of Soluble Dietary Fibers on Lipase-catalyzed Hydrolysis of Tributyrin
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Reduction of the amount of intestinal secretory IgA in fulminant hepatic failure
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Recommended from our members
Methodology for studying postprandial lipid metabolism
- Author
- A Harbis
- A Harbis
- A Lia
- A Pedersen
- A Zampelas
- A Zampelas
- A Zampelas
- AE Hardman
- AH Lichtenstein
- AM Lorec
- AM Minihane
- AR Sharrett
- AS Bickerton
- B Guerci
- B Guerci
- B Verges
- BA Fielding
- BA Fielding
- BO Schneeman
- BO Schneeman
- C Couillard
- C Dubois
- C Dubois
- C Marcoux
- C Thomsen
- C Williams
- CL Redard
- CM Williams
- CM Williams
- CM Williams
- D Lairon
- D Lairon
- D Smith
- D Smith
- EJ Schaefer
- F Karpe
- F Karpe
- F Karpe
- F Karpe
- F Nappo
- F Shishehbor
- FK Welty
- G Beaumier-Gallon
- GC Burdge
- GF Lewis
- H Demmelmair
- HM Roche
- HM Roche
- HM Roche
- HM Roche
- HM Roche
- J Dallongeville
- J Jeppesen
- J Lopez-Miranda
- J Lopez-Miranda
- J Lopez-Miranda
- J Lopez-Miranda
- J Lopez-Miranda
- J Lopez-Miranda
- JA Lovegrove
- JA Lovegrove
- JA Lovegrove
- JA Moreno
- JC Cohen
- JC Cohen
- JH Bae
- JM Ordovas
- JP van Wijk
- JR Patsch
- JR Patsch
- JS Cohn
- JS Cohn
- JS Cohn
- K Evans
- K Moore
- KD Silva
- KD Silva
- KG Jackson
- KG Jackson
- KG Jackson
- KG Jackson
- KG Jackson
- KI Grant
- KN Frayn
- KN Frayn
- L Cara
- L Tiret
- LA Pennacchio
- M Armand
- M Armand
- M Romon
- M Syvanne
- MC Murphy
- MD Robertson
- MM Jensen
- MS Weintraub
- MS Weintraub
- MS Weintraub
- N Mekki
- N Mekki
- N Mero
- N Tentolouris
- OT Raitakari
- P Blackburn
- P Sauvant
- PH Groot
- S Hadjadj
- S Vincent
- SB Votruba
- SQ Ye
- SW Sakr
- T Tholstrup
- TW de Bruin
- UB Johansson
- V Tyssandier
- YD Chen
- YE Finnegan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/04/2007
- Field of study
Background: Postprandial lipid metabolism in humans has deserved much attention during the last two decades. Although fasting lipid and lipoprotein parameters reflect body homeostasis to some extent, the transient lipid and lipoprotein accumulation that occurs in the circulation after a fat-containing meal highlights the individual capacity to handle an acute fat input. An exacerbated postprandial accumulation of triglyceride-rich lipoproteins in the circulation has been associated with an increased cardiovascular risk. Methods: The important number of studies published in this field raises the question of the methodology used for such postprandial studies, as reviewed. Results: Based on our experiences, the present review reports and discuss the numerous methodological issues involved to serve as a basis for further works. These aspects include aims of the postprandial tests, size and nutrient composition of the test meals and background diets, pre-test conditions, characteristics of subjects involved, timing of sampling, suitable markers of postprandial lipid metabolism and calculations. Conclusion: In conclusion, we stress the need for standardization of postprandial tests
Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men
- Author
- A Georgopoulos
- A Lee
- A Rivera-Coll
- A Zampelas
- A Zampelas
- AD Sniderman
- AE Jones
- AI Salhanick
- AJ Brown
- BA Fielding
- BO Schneeman
- C Couillard
- C Koutsari
- CD Byrne
- CM Williams
- DL Topping
- F Karpe
- F Karpe
- F Shishehbor
- FJ Service
- G Schlierf
- GC Burdge
- GC Burdge
- GC Burdge
- GF Lewis
- GF Lewis
- GF Lewis
- GM Reaven
- J Bjorkegren
- J Bulow
- JA Lovegrove
- JC Cohen
- JD Sparks
- JE Swanson
- JI Mann
- JL Folch
- JR Patsch
- JS Cohn
- JS Samra
- K Evans
- K Evans
- KE Friday
- KF Carroll
- KG Jackson
- KH Vogelberg
- KI Grant
- KN Frayn
- KN Frayn
- KN Frayn
- M Romon
- ME Laker
- MJ Stampfer
- MS Weintraub
- N Bergeron
- N Dashti
- N Yahia
- PJ Barter
- PJ Nestel
- PN Durrington
- R Malmstrom
- R Malmstrom
- R Malmstrom
- RJ Jarrett
- SL Shumak
- TWA de Bruin
- WS Harris
- WS Harris
- WS Harris
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/11/2003
- Field of study
Objective: To investigate whether the postprandial changes in plasma triacylglycerol (TAG), nonesterified fatty acids (NEFA), glucose and insulin concentrations in young men were the same if an identical meal was fed at breakfast and lunch, and if the response to lunch was modified by consumption of breakfast.Methods: In two trials (1 and 2) healthy subjects (age 22±1 y, body mass index 22±2 kg/m2) were fed the same mixed macronutrient meal at breakfast at 08:00 h and lunch at 14:00 h. In the third trial, no breakfast was fed and the overnight fast extended until lunch at 14:00 h. Addition of [1,1,1-13C]tripalmitin to one meal in each trial was used to distinguish between endogenous and meal-derived lipids.Results: The postprandial changes in TAG, NEFA and glucose concentrations were similar in trials 1 and 2. The change in plasma total TAG concentration was about two fold less (P<0.05) after lunch compared to breakfast. Postprandial NEFA suppression was the same after breakfast and lunch. Glucose and insulin responses were significantly greater following lunch suggesting decreasing insulin sensitivity during the day. Consumption of breakfast did not alter the postprandial total TAG or NEFA responses after lunch. Measurement of [13C]palmitic acid concentration showed that handling of TAG and NEFA from the meal was the same after breakfast and lunch, and was not altered by consumption of breakfast.Conclusions: Overall, these data suggest that in young, healthy men regulation of plasma TAG from endogenous sources, principally VLDL, but not chylomicrons during the postprandial period leads to differences in the magnitude of lipaemic response when the same meal was consumed at breakfast or at lunch 6 h later.<br/
The USDA trypsin inhibitor study. I. Background, objectives, and procedural details
- Author
- A Andren-Sandberg
- A Hasdai
- A Krogdahl
- A Pap
- American Oil Chemists' Society
- BA Schneeman
- BD Roebuck
- BD Roebuck
- BH Doell
- BJ Struthers
- BR Krawisz
- Brabender Rapid Moisture Tester
- C Figarella
- D Jacobson
- DA Levison
- E Lebenthal
- EE Mc Guinness
- EE McGuinness
- EE McGuinness
- GE Hamestrand
- GM Green
- GM Green
- GM Green
- GM Green
- GM Green
- HR Churella
- I Chen
- I Ihse
- IE Liener
- IE Liner
- J Dlugosz
- J Hotz
- JC Vitoria
- JH Lewis
- JJ Rackis
- JJ Rackis
- JJ Rackis
- JJ Rackis
- JW Sissons
- JW Sissons
- K Miyasaka
- K Warner
- LA Moroz
- LR Johnson
- M Shibasaki
- M Singh
- MD Rio del
- MG Davies
- MJ Treffot
- ML Kakade
- ML Kakade
- PM Pour
- RA Crass
- RA Crass
- RA Gunn
- RC Theuer
- RGH Morgan
- RN Fiddler
- RS Temler
- RS Temler
- RS Temler
- RS Temler
- S Cohen
- S Moore
- SNS Murthy
- Symposium: Current Progress in Pancreatic Carcinogenesis research
- Symposium: Nutrition in the causation of cancer
- T Fazio
- Technicon Instrument Corporation
- UR Folsch
- UR Folsch
- W Creutzfeldt
- Y Yanatori
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
Postprandial lipoprotein metabolism and atherosclerosis
- Author
- Aalto-Setala K
- Agnani G
- Alaupovic P
- Bergeron N
- Bjorkegren J
- Bjorkegren J
- Bjorkegren J
- Boren J
- Bowler A
- Brunzell JD
- Campos E
- Chen S-H
- Chen YD
- Chen YD
- Chen YD
- Clifton PM
- Cohn JS
- Cohn JS
- Demant T
- deSilva HV
- Dubois C
- Dubois C
- Dullaart Rpf
- Eriksson P
- Fielding BA
- Frayn KN
- Fraze E
- Gaw A
- Gianturco SH
- Ginsberg HN
- Ginsberg HN
- Gronholdt ML
- Gronholdt ML
- Gronholdt ML
- Groop LC
- Groot Phe
- Grundy SM
- Hamsten A
- Havel RJ.
- Hayashi H
- Hazzard WR
- Hennig B
- Hennig B
- Hodis HN
- Hughes TA
- Ishibashi S
- Jong MC
- Kane JP
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Karpe F
- Katzel LI
- Kissebah AH
- Kita T
- Lassel TS
- Lichtenstein AH
- Lundman P
- Malmstrom R
- Mann CJ
- McNamara JR
- Nakajima K
- Nestel PJ.
- Nikkila M
- Ong JM
- Patsch J.
- Patsch JR
- Phillips ML
- Phillips NR
- Powell LM
- Rapp JH
- Rohlmann A
- Rose HG
- Rubinsztein DC
- Ryu JE
- Schneeman BO
- Schumaker V
- Shachter NS
- Shachter NS
- Shaikh M
- Sharrett AR
- Silveira A
- Silveira A
- Simons LA
- Simpson HS
- Sniderman AD
- Sullivan PM
- Syvanne M
- Tall AR
- Tall AR
- Tornvall P
- Tso P
- Uiterwaal Cspm
- Veniant MM
- Wallentin L
- Watts GF
- Weintraub MS
- Weisgraber KH
- Willnow TE
- Windler E
- Zhang SH
- Zilversmit DB.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Listing of Protein Spectra
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- . Yeshoda S. C. Dhar., and M. Santappa, Ital
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- A Arens
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- A Colosimo
- A Danchin
- A Ducastaing
- A D’Aniello
- A Ehrenberg
- A Fattoum
- A Finazzi-Agro
- A Finazzi-Agro
- A Finazzi-Agro
- A Finazzi-Agro
- A Fiori
- A Flangas
- A Flores-Careon
- A Fontana
- A Fontana
- A Gafni
- A Ghiretti-Magaldi
- A Golichowski
- A Goswami
- A Grinvald
- A Hayashi
- A Hayashi
- A Hayashi
- A Hayashi
- A Hiramatsu
- A Hiwatashi
- A Hiwatashi
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- A Holmeren
- A Holmgren
- A Holmgren
- A Ishimaru
- A Ishimaru
- A Jerfy
- A Jonas
- A Kamogawa
- A Kusai
- A Lindstrom
- A Lindstrom
- A Magne
- A Mansouri
- A Mitsui
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- A Nieto
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- A Vidnes
- A Waheed
- A Weissler
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- A Yoshida
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- A B, and C H. A. Kareem, A. M. Gilles, T. Nguyen-Thanh, and B. Keil, Comp
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- AC Chung
- AC Murray
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- BB Klee
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- BJ Clayton
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- derivatives in solvent b A. Jonas J
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- YA Sharonov
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- YE Erokhin
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- Z Bradic
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study