Novel Bound States Treatment of the Two Dimensional Schrodinger Equation with Pseudocentral Plus Multiparameter Noncentral Potential

By converting the rectangular basis potential V(x,y) into the form as V(r)+V(r, phi) described by the pseudo central plus noncentral potential, particular solutions of the two dimensional Schrodinger equation in plane-polar coordinates have been carried out through the analytic approaching technique of the Nikiforov and Uvarov (NUT). Both the exact bound state energy spectra and the corresponding bound state wavefunctions of the complete system are determined explicitly and in closed forms. Our presented results are identical to those of the previous works and they may also be useful for investigation and analysis of structural characteristics in a variety of quantum systemsComment: Published, 16 page

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria