Origin of 1015−101610^{15}-10^{16}G Magnetic Fields in the Central Engine of Gamma Ray Bursts

Various authors have suggested that the gamma-ray burst (GRB) central engine is a rapidly rotating, strongly magnetized, $(\sim 10^{15}-10^{16}$ G) compact object. The strong magnetic field can accelerate and collimate the relativistic flow and the rotation of the compact object can be the energy source of the GRB. The major problem in this scenario is the difficulty of finding an astrophysical mechanism for obtaining such intense fields. Whereas, in principle, a neutron star could maintain such strong fields, it is difficult to justify a scenario for their creation. If the compact object is a black hole, the problem is more difficult since, according to general relativity it has "no hair" (i.e., no magnetic field). Schuster, Blackett, Pauli, and others have suggested that a rotating neutral body can create a magnetic field by non-minimal gravitational-electromagnetic coupling (NMGEC). The Schuster-Blackett form of NMGEC was obtained from the Mikhail and Wanas's tetrad theory of gravitation (MW). We call the general theory NMGEC-MW. We investigate here the possible origin of the intense magnetic fields $\sim 10^{15}-10^{16}$ G in GRBs by NMGEC-MW. Whereas these fields are difficult to explain astrophysically, we find that they are easily explained by NMGEC-MW. It not only explains the origin of the $\sim 10^{15}-10^{16}$G fields when the compact object is a neutron star, but also when it is a black hole.Comment: 9 pages, accepted for publication in JCA

Interferon beta in multiple sclerosis: experience in a British specialist multiple sclerosis centre

Background: The efficacy of interferon beta (IFN beta) is well established in relapsing-remitting multiple sclerosis (MS). However, the use of this drug in clinical practice is complex, especially because it is only partially effective, its long term efficacy and side effects are unknown, its efficacy may be abrogated by the development of neutralising antibodies, compliance is variable, and its cost effectiveness is controversial. Objectives and Methods: Analysis of a prospectively followed up series of 101 MS patients treated with IFN beta was undertaken to: (1) monitor the outcome of IFN beta treatment in clinical practice; (2) compare the immunogenicity of the three commercial IFN beta preparations available; (3) assess the proportion of patients fulfilling the current guidelines of the Association of British Neurologists for stopping IFN beta therapy. Results: During a median treatment period of 26 months (range 2–85), the relapse rate decreased by 41%. Although the reduction in the relapse rate was similar for all three commercial products, none of the Avonex treated patients were relapse free, compared with 19% of the Betaferon treated and 27% of the Rebif treated patients (p=0.02). Neutralising antibodies were not detected in Avonex treated patients (0 of 18), compared with 12 of 32 (38%) Betaferon treated and 10 of 23 (44%) Rebif treated patients (p=0.02). Forty of 101 (40%) patients satisfied the current (2001) Association of British Neurologists criteria for stopping IFN beta treatment at some stage during their treatment. Conclusion: IFN beta is effective in reducing the relapse rate in patients with relapsing-remitting MS in routine clinical practice. However, after a median treatment duration of 26 months, 40% of initially relapsing-remitting MS patients seem to have ongoing disease activity, presenting as disabling relapses or insidious progression

Relativistic Ring-Diagram Nuclear Matter Calculations

A relativistic extension of the particle-particle hole-hole ring-diagram many-body formalism is developed by using the Dirac equation for single-particle motion in the medium. Applying this new formalism, calculations are performed for nuclear matter. The results show that the saturation density is improved and the equation of state becomes softer as compared to corresponding Dirac-Brueckner-Hartree-Fock calculations. Using the Bonn A potential, nuclear matter is predicted to saturate at an energy per nucleon of --15.30 MeV and a density equivalent to a Fermi momentum of 1.38 fm$^{-1}$, in excellent agreement with empirical information. The compression modulus is 152 MeV at the saturation point.Comment: 23 pages text (LaTex) and 2 figures (paper, will be faxed upon request), UI-NTH-92-0

Information Presentation

The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center

A methodology to compile multi-hazard interrelationships in a data-scarce setting: an application to Kathmandu Valley, Nepal

This paper introduces a multifaceted methodology to identify and compile single natural hazards and multi-hazard interrelationships within the context of data-scarce urban settings, exemplified by Kathmandu Valley, Nepal. This approach integrates (i) five blended types of evidence to support a more nuanced and holistic understanding of a hazardscape where data are scarce and (ii) a 2-hour stakeholder workshop with seven participants to provide greater context to the hazards, consider their impacts through the co-production of multi-hazard interrelationship scenarios, and how this methodology could support more people-centred disaster risk reduction (DRR) strategies. We use blended evidence types, including academic literature, grey literature, media, databases, and social media, to systematically search for exemplars of single hazards and multi-hazard interrelationships that have influenced or could potentially influence Kathmandu Valley. We collated 58 sources of evidence for single hazards and 21 sources of evidence for multi-hazard interrelationships. Using these sources, our study identified 21 single hazard types across six hazard groups (geophysical, hydrological, shallow Earth processes, atmospheric, biophysical, and space/celestial hazards) and 83 multi-hazard interrelationships (12 that have direct case study evidence of previous influence in Kathmandu Valley) that might influence Kathmandu Valley. These exemplars are collated into two databases that accompany this paper. We supplement these exemplars with multi-hazard interrelationship scenarios and multi-hazard impacts developed by stakeholders engaged in DRR research and practice in Kathmandu Valley. The results illustrate the complexity of the hazard landscape, with many single hazards and multi-hazard interrelationships potentially influencing Kathmandu Valley. The research emphasises the importance of inclusive DRR strategies that recognise disaggregated impacts experienced by different social groups. This knowledge can inform the development of dynamic risk scenarios in planning and civil protection, thus strengthening multi-hazard approaches to DRR in “Global South” urban areas such as Kathmandu Valley

Gut microbiome and brain functional connectivity in infants-a preliminary study focusing on the amygdala

Recently, there has been a surge of interest in the possibility that microbial communities inhabiting the human gut could affect cognitive development and increase risk for mental illness via the “microbiome-gut-brain axis.” Infancy likely represents a critical period for the establishment of these relationships, as it is the most dynamic stage of postnatal brain development and a key period in the maturation of the microbiome. Indeed, recent reports indicate that characteristics of the infant gut microbiome are associated with both temperament and cognitive performance. The neural circuits underlying these relationships have not yet been delineated. To address this gap, resting-state fMRI scans were acquired from 39 1-year-old human infants who had provided fecal samples for identification and relative quantification of bacterial taxa. Measures of alpha diversity were generated and tested for associations with measures of functional connectivity. Primary analyses focused on the amygdala as manipulation of the gut microbiota in animal models alters the structure and neurochemistry of this brain region. Secondary analyses explored functional connectivity of nine canonical resting-state functional networks. Alpha diversity was significantly associated with functional connectivity between the amygdala and thalamus and between the anterior cingulate cortex and anterior insula. These regions play an important role in processing/responding to threat. Alpha diversity was also associated with functional connectivity between the supplementary motor area (SMA, representing the sensorimotor network) and the inferior parietal lobule (IPL). Importantly, SMA-IPL connectivity also related to cognitive outcomes at 2 years of age, suggesting a potential pathway linking gut microbiome diversity and cognitive outcomes during infancy. These results provide exciting new insights into the gut-brain axis during early human development and should stimulate further studies into whether microbiome-associated changes in brain circuitry influence later risk for psychopathology

Spin-dependent effective interactions for halo nuclei

We discuss the spin-dependence of the effective two-body interactions appropriate for three-body computations. The only reasonable choice seems to be the fine and hyperfine interactions known for atomic electrons interacting with the nucleus. One exception is the nucleon-nucleon interaction imposing a different type of symmetry. We use the two-neutron halo nucleus 11Li as illustration. We demonstrate that models with the wrong spin-dependence are basically without predictive power. The Pauli forbidden core and valence states must be consistently treated.Comment: TeX file, 6 pages, 3 postscript figure

A case study on grammatical-based representation for regular expression evolution

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-12433-4_45Proceedings of 8th International Conference on Practical Applications of Agents and Multiagent SystemsRegular expressions, or simply regex, have been widely used as a powerful pattern matching and text extractor tool through decades. Although they provide a powerful and flexible notation to define and retrieve patterns from text, the syntax and the grammatical rules of these regex notations are not easy to use, and even to understand. Any regex can be represented as a Deterministic or Non-Deterministic Finite Automata; so it is possible to design a representation to automatically build a regex, and a optimization algorithm able to find the best regex in terms of complexity. This paper introduces both, a graph-based representation for regex, and a particular heuristic-based evolutionary computing algorithm based on grammatical features from this language in a particular data extraction problem.This work has been partially supported by the Spanish Ministry of Science and Innovation under the projects Castilla-La Mancha project PEII09-0266-6640, COMPUBIODIVE (TIN2007-65989), and by HADA (TIN2007-64718)

Computational Nuclear Physics and Post Hartree-Fock Methods

We present a computational approach to infinite nuclear matter employing Hartree-Fock theory, many-body perturbation theory and coupled cluster theory. These lectures are closely linked with those of chapters 9, 10 and 11 and serve as input for the correlation functions employed in Monte Carlo calculations in chapter 9, the in-medium similarity renormalization group theory of dense fermionic systems of chapter 10 and the Green's function approach in chapter 11. We provide extensive code examples and benchmark calculations, allowing thereby an eventual reader to start writing her/his own codes. We start with an object-oriented serial code and end with discussions on strategies for porting the code to present and planned high-performance computing facilities.Comment: 82 pages, to appear in Lecture Notes in Physics (Springer), "An advanced course in computational nuclear physics: Bridging the scales from quarks to neutron stars", M. Hjorth-Jensen, M. P. Lombardo, U. van Kolck, Editor

Family-based obesity prevention for infants: Design of the “Mothers & Others” randomized trial

Objective Our goal is to test the efficacy of a family-based, multi-component intervention focused on infants of African-American (AA) mothers and families, a minority population at elevated risk for pediatric obesity, versus a child safety attention-control group to promote healthy weight gain patterns during the first two years of life. Design, participants, and methods The design is a two-group randomized controlled trial among 468 AA pregnant women in central North Carolina. Mothers and study partners in the intervention group receive anticipatory guidance on breastfeeding, responsive feeding, use of non-food soothing techniques for infant crying, appropriate timing and quality of complementary feeding, age-appropriate infant sleep, and minimization of TV/media. The primary delivery channel is 6 home visits by a peer educator, 4 interim newsletters and twice-weekly text messaging. Intervention families also receive 2 home visits from an International Board Certified Lactation Consultant. Assessments occur at 28 and 37 weeks gestation and when infants are 1, 3, 6, 9, 12, and 15 months of age. Results The primary outcome is infant/toddler growth and likelihood of overweight at 15 months. Differences between groups are expected to be achieved through uptake of the targeted infant feeding and care behaviors (secondary outcomes) and change in caregivers' modifiable risk factors (mediators) underpinning the intervention. Conclusions If successful in promoting healthy infant growth and enhancing caregiver behaviors, “Mothers and Others” will have high public health relevance for future obesity-prevention efforts aimed at children younger than 2 years, including interventional research and federal, state, and community health programs. Trial Registration ClinicalTrials.gov, NCT01938118, August 9, 2013