Parotid gland biopsy in the diagnosis of sarcoidosis

Objective: To assess the informative value of parotid gland (PG) biopsy in the diagnosis of sarcoidosis. Subjects and methods. PG biopsy was made in 15 patients (4 males and 11 females) with a presumptive diagnosis of sarcoidosis. The patients were grouped by the presence of PG enlargement. Results. By taking into account clinicoinstrumental data and found morphological changes, three (20%) and 12 (80%) patients were diagnosed as having multifocal fibrosclerosis and sarcoidosis, respectively. PG biopsy could establish a histologically verified diagnosis in 100% of cases (that of sarcoidosis (50%) and multifocal fibrosclerosis (50%) in the enlarged PG group (n=6)); sarcoidosis was diagnosed in 67% of cases in the non-enlarged PG group (n=9). Epithelioid cell granulomas were detectable in 100 and 50% of the patients with sarcoidosis in its active (n=6) and remission (n=6) phases, respectively. Conclusion. PG biopsy is of high diagnostic value and may be used in the diagnosis of sarcoidosis

Rituximab in the treatment of nodal Bcell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitis

Rituximab in the treatment of nodal B- cell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitis A case of nodal B- cell marginal zone lymphoma, primary Sjogren’s syndrome and autoimmune hepatitis treated with rituximab is presented